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Clinical trials for Simvastatin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    200 result(s) found for: Simvastatin. Displaying page 1 of 10.
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    EudraCT Number: 2006-004396-35 Sponsor Protocol Number: 06078SE-A Start Date*: 2006-10-25
    Sponsor Name:Belfast City Hospital Trust
    Full Title: Investigation of the anti-inflammatory effects of simvastatin in a model of acute lung injury after inhalation of lipopolysaccharide by healthy volunteers
    Medical condition: Acute lung injury (ALI)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-002851-41 Sponsor Protocol Number: 1228.1 Start Date*: 2006-03-07
    Sponsor Name:Boehringer Ingelheim Pharma GmbH & Co. KG
    Full Title: Reduced factorial design, randomized, double blind trial comparing combinations of telmisartan 20 or 80 mg and simvastatin 20 or 40 mg with single component therapies in the treatment of hypertensi...
    Medical condition: hypertension and dyslipidaemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SE (Completed) SK (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2005-003270-14 Sponsor Protocol Number: C LF0242780-01 05 01 Start Date*: 2005-12-13
    Sponsor Name:FOURNIER Laboratories Ireland Ltd
    Full Title: A multicenter, double-blind, randomized, active comparator, forced-titration study to compare the efficacy and safety of the combination of 145 mg fenofibrate and 20 or 40 mg simvastatin with 40 mg...
    Medical condition: Study in patients with mixed dyslipidemia at risk of cardiovascular disease not adequately controlled by 20 mg simvastatin alone
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) CZ (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2007-002454-37 Sponsor Protocol Number: RGHT000392 Start Date*: 2007-07-20
    Sponsor Name:The Royal Group Hospitals Trust
    Full Title: Prevention by HMGCoA reductase inhibition of ALI associated with one lung ventilation following oesophagectomy by a Reduction of Pulmonary vascular dysfunction and inflammation (Prevention-HARP)
    Medical condition: Acute lung injury (ALI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005924-16 Sponsor Protocol Number: M13-377 Start Date*: 2012-06-13
    Sponsor Name:Abbott Laboratories Ireland Limited
    Full Title: A 12-week, Double-blind, Randomized Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate /Simvastatin 145/20mg and Fenofibrate / Simvastatin 145/40mg Tablets vs. Matching M...
    Medical condition: Dyslipidemia
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004861 10058110 Dyslipidemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2015-004334-99 Sponsor Protocol Number: 151201 Start Date*: 2016-02-01
    Sponsor Name:Department of Endocrinology
    Full Title: Treatment of Graves´ ophthalmopathy with diclofenak or simvastatin
    Medical condition: Graves´ophthalmopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2005-003438-17 Sponsor Protocol Number: 05/Q1606/143 Start Date*: 2005-11-07
    Sponsor Name:Oxford Radcliffe Hospitals NHS Trust
    Full Title: SimSepT: Simvastatin and severe sepsis in the ICU
    Medical condition: Severe sepsis
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-000989-39 Sponsor Protocol Number: STRU -02-05 Start Date*: 2005-09-23
    Sponsor Name:Guy's & St Thomas NHS foundation Trust
    Full Title: A Single Centre, double blind, placebo controlled, randomised trial to evaluate the efficacy and safety of Simvastatin in the treatment of Psoriasis.
    Medical condition: Psoriasis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-006234-34 Sponsor Protocol Number: CD07/8396 Start Date*: 2008-08-18
    Sponsor Name:University of Leeds
    Full Title: 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: endothelial and endothelial progenitor cell function in men
    Medical condition: Objectives:To investigate whether statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) improve endothelial dysfunction in healthy volunteers (men). Endothelial dysfunction is an ear...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-001196-46 Sponsor Protocol Number: OPHT-240215 Start Date*: 2015-05-15
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of simvastatin withdrawal on ocular endothelial function
    Medical condition: endothelial dysfunction in cardiovascular diseases
    Disease: Version SOC Term Classification Code Term Level
    19.1 10047065 - Vascular disorders 10048554 Endothelial dysfunction PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2009-017689-22 Sponsor Protocol Number: 09105 Start Date*: 2010-04-20
    Sponsor Name:University of Nottingham
    Full Title: The Cardiovascular and Inflammatory Effects of Statin Therapy in Patients with COPD
    Medical condition: Chronic Obstructive Pulmonary Disease (COPD)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-001466-14 Sponsor Protocol Number: MEN002 Start Date*: 2005-05-26
    Sponsor Name:University of Dundee
    Full Title: A Proof of Concept Study to Investigate the use of Simvastatin as a Putative Anti-inflammatory Agent in Asthma
    Medical condition: Asthma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001715-76 Sponsor Protocol Number: FTB13-SMV01 Start Date*: 2013-09-05
    Sponsor Name:KU Leuven-Drug Delivery and Disposition
    Full Title: Gastrointestinal behavior of simvastatin in healthy volunteers
    Medical condition: Healthy volunteers (administration of a hypolipidemic drug)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2011-002082-38 Sponsor Protocol Number: RG_11-123 Start Date*: 2012-04-16
    Sponsor Name:University of Birmingham
    Full Title: A study of the effects of Simvastatin on neutrophil function in elderly subjects
    Medical condition: We are investigating the effects of Simvastatin 80mg on neutrophil function (using in vitro studies of neutrophil function), in healthy elderly subjects as there is evidence to suggest that Simvast...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-007689-52 Sponsor Protocol Number: 0653A-133 Start Date*: 2009-05-27
    Sponsor Name:Merck & Co. Inc.
    Full Title: A Randomized, Double-Blind, Active-Controlled, Multicenter Study of Patients with Cardiovascular Disease and Diabetes Mellitus Not Adequately Controlled with Simvastatin 20 mg or Atorvastatin 10 mg...
    Medical condition: Lipids not at goal in diabetic patients with cardiovascular disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020604 Hypercholesterolemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed) HU (Completed) DE (Completed) LV (Completed) AT (Completed) EE (Completed) IT (Completed) PT (Completed) BG (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2005-004421-26 Sponsor Protocol Number: Leipzig-01 Start Date*: 2006-07-18
    Sponsor Name:Institut fuer Gesundheits- und Praxismanagement GmbH
    Full Title: Effect of Pioglitazone on Intima Media Thickness, Endothelial Function and Heart Rate Variability in Patients with Impaired Glucose Tolerance
    Medical condition: Impaired glucose tolerance
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2009-010965-22 Sponsor Protocol Number: NF1-SIMCODA Start Date*: 2009-09-29
    Sponsor Name:Erasmus MC - Department of Pediatrics
    Full Title: The effect of long-term simvastatin treatment on cognitive function and daily life in children with Neurofibromatosis 1: a one year randomized controlled trial
    Medical condition: Neurofibromatosis 1
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2005-004080-28 Sponsor Protocol Number: 024-08-2005 Start Date*: 2005-11-02
    Sponsor Name:Sandwell Medical Research Unit
    Full Title: Efficacy and Safety of Niaspan in South Asian Stroke Survivors: NIASTAR TRIAL (Niaspan: Indo-Asian Stroke patienT Atherosclerotic Regression trial)
    Medical condition: 1. Patients diagnosed as having a stroke based on the WHO Criteria Patients with transient ischaemic attacks will be included if symptoms of motor or sensory loss were demonstrable with full recove...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000959-92 Sponsor Protocol Number: 2014-647 Start Date*: 2014-04-24
    Sponsor Name:Department of Clinical Pharmacology Q
    Full Title: A randomized, double-blinded, Placebo controlled study of simvastatins possible effect on oxidative stress on healthy volunteers
    Medical condition: Simvasatins effect on Oxidative Stress
    Disease: Version SOC Term Classification Code Term Level
    17.0 10022891 - Investigations 10022891 Investigations SOC
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-000834-36 Sponsor Protocol Number: 43806 Start Date*: 2013-09-26
    Sponsor Name:University Medical Center Utrecht
    Full Title: Simvastatin addition to improve symptoms, cognition and metabolic syndrome in patients with recent-onset schizophrenia.
    Medical condition: Schizophrenia, schizoaffective or schizophreniform disorder (DSM-IV 295.*) or psychosis NOS (not otherwise specified) (298.9)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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