Amendment 1: Amendment #1, dated 22-Oct-2013, described changes made to the original protocol Version 2.0 and was used to create a separate protocol for use in Bulgaria only (Version 3.0). The following changes were made in Amendment #1, to comply with recommendations made by the Bulgarian Drug Agency: • The in- and exclusion criteria were amended to exclude patients who were at risk of developing side effects of the study medicinal products (active comparators), or of gadolinium, or in whom the active control products were contraindicated. • Continuous mental monitoring with the help of the PHQ-9 questionnaire, a standard and validated tool for assessing and monitoring depression severity, was to be conducted for Bulgarian patients who were to receive active comparator. • The investigator was to discuss further treatment options with the patient already after a first confirmed relapse or a worsening of EDSS by at least 1.0 point confirmed at two assessments separated by at least 12 weeks during the treatment period. After a second confirmed relapse, the patient was to be withdrawn and was to be treated with available medication best suitable for the patient at the Investigator’s discretion.

Amendment 2: Amendment #2, dated 27-Nov-2013, described changes made to the original protocol Version 2.0 and was used to create a separate protocol for use in Russia only (Version 4.0), to comply with recommendations made by the Russian Drug Agency: • As the study investigated a theory of validity of use of a HAP score and the drug efficacy within the treatment of MS, it was recommended to change the phase of the study to Phase 2. • The primary endpoint was amended to clearly reflect that the decision on predicted response or predicted non-response was made on the basis of the HAP score.

Amendment 3: Amendment #3, dated 22-May-2014, described changes made to protocol Version 2.0 and was used to create Version 5.0 of the protocol used in all countries except Bulgaria and Russia. This version was used as the basis for this clinical study report. The same changes were incorporated into Version 3.0 of the protocol to produce Version 6.0 for Bulgaria, and into Version 4.0 of the protocol to produce Version 7.0 for Russia. The amendment was issued primarily to incorporate advice from the Steering Committee on the exclusion criteria and support enrolment of patients without biasing the study results with the slightly enlarged study population and to maintain the safety of the participants: • The exclusion criterion #2 on excluding patients who had ever had any previous treatment with immunosuppressive agents was amended to a wording that excluded immunosuppressive medication such as azathioprine, mitoxantrone, cyclophosphamide, as well as teriflunomide or fingolimod, in the previous 6 months prior to inclusion in the study. A new exclusion criterion was added to exclude treatment with biological immunosuppressants such as rituximab or similar immune cell depleting therapies in the previous 18 months. • A new exclusion criterion was added: patients with a history of deep vein thrombosis or thrombotic complications after IVIG therapy were excluded to cover for potential predisposition to IVIG side effects. • Clinical response definition had been slightly inconsistent with regard to MRI activity, and was therefore unambiguously stated in a new separate section of the protocol (Section 3.2.4, Clinical Response Definition). • Shipment of blood samples to Heidelberg, Germany for HAP assay was specified to be done on the same day as the blood draw, with arrival at 10 am the following day the latest. • It was clarified that, for the first 50 patients, IMP treatment was to be started only when the Central Laboratory had confirmed arrival of the post-screenin

Amendment 4: Amendment #4, dated 06-Oct-2015, described changes made to protocol Version 5.0 and was used to create Version 8.0 of the protocol, used in all countries except Bulgaria and Russia. The same changes were incorporated into Version 6.0 of the protocol to produce Version 9.0 for Bulgaria, and into Version 7.0 of the protocol to produce Version 10.0 for Russia. As the study was prematurely discontinued, no patients were enrolled under this amendment.