E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Molybdenum CoFactor Deficiency (MoCD) Type A |
Déficit del cofactor molibdeno (DCMo) de tipo A |
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E.1.1.1 | Medical condition in easily understood language |
Molybdenum CoFactor Deficiency |
|
E.1.1.2 | Therapeutic area | Diseases [C] - Nutritional and Metabolic Diseases [C18] |
MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 19.0 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10069687 |
E.1.2 | Term | Molybdenum cofactor deficiency |
E.1.2 | System Organ Class | 10010331 - Congenital, familial and genetic disorders |
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E.1.3 | Condition being studied is a rare disease | Yes |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
To evaluate the safety and efficacy of ALXN1101 in neonate patients with MoCD Type A |
Evaluar la eficacia y la seguridad de ALXN1101 en pacientes neonatos con DCMo de tipo A |
|
E.2.2 | Secondary objectives of the trial |
- To evaluate the effect of ALXN1101 on acquisition of developmental milestones
- To evaluate the effect of ALXN1101 on pediatric measures of functional ability and activities of daily living
- To characterize the pharmacokinetics (PK) of ALXN1101 |
-Evaluar el efecto de ALXN1101 en la adquisición de hitos en el desarrollo
-Evaluar el efecto de ALXN1101 en medidas pediátricas de la capacidad funcional y de las actividades de la vida cotidiana
-Caracterizar la farmacocinética (FC) de ALXN1101 |
|
E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
- Male or female neonatal patient (1 to 28 days of age [inclusive] at the time of ALXN1101 administration, with day 1 of age corresponding to the day of birth)
- Diagnosis of MoCD Type A, based on
- Prenatal genetic diagnosis, or
- Onset of clinical and/or laboratory signs and symptoms consistent with MoCD Type A within the first 28 days after birth
- Parent or legal guardian must have signed the informed consent form (ICF) prior to any study procedures being performed |
-Pacientes neonatos de ambos sexos (de 1 a 28 días de edad [inclusive] en el momento de la administración de ALXN1101, donde el día 1 se corresponde con la fecha de nacimiento).
-Diagnóstico de DCMo de tipo A, en base a
o Diagnósticos genéticos prenatales, o
o Aparición de signos y síntomas clínicos y/o analíticos coherentes con el DCMo de tipo A
en los primeros 28 días tras el nacimiento
- El progenitor o tutor legal debe haber firmado el formulario de consentimiento informado (FCI) antes de llevar a cabo cualquier procedimiento del estudio |
|
E.4 | Principal exclusion criteria |
- Diagnosis other than MoCD Type A (may be determined after the initiation of study drug)
- Condition that is considered by the treating physician to be a contraindication to therapy, including evidence of abnormalities on brain imaging not attributable to MoCD Type A, or that might otherwise interfere with the patient?s participation in the study, pose any additional risk for the patient, or confound patient assessments
- Antenatal and/or postnatal brain imaging prior to initiation of treatment with ALXN1101 that indicates cortical or subcortical cystic encephalomalacia, clinically significant intracranial hemorrhage, or other abnormalities on brain imaging determined by the treating physician to be clinically significant
- Modified Glasgow Coma Scale (mGCS) for Infants and Children score of less than 7 for more than 24 hours (This criterion does not apply to children less than 1 day of age) |
-Diagnóstico diferente a DCMo de tipo A (puede determinarse después del inicio del fármaco del estudio).
-Trastorno que el médico responsable considere como una contraindicación al tratamiento, incluidas evidencias de anomalías en pruebas por imagen del cerebro no atribuibles al DCMo de tipo A, o que pueda interferir con la participación del paciente en el estudio, conllevar un riesgo adicional para el paciente o confundir sus evaluaciones.
-Pruebas por imagen del cerebro prenatales y/o posnatales previas al inicio del tratamiento con ALXN1101 que indican encefalomalacia quística cortical o subcortical, hemorragia intracraneal clínicamente significativa u otras anomalías en las pruebas por imagen del cerebro determinadas por el médico responsable del tratamiento como clínicamente significativas.
-Escala de coma de Glasgow modificada (modified Glasgow Coma Scale, mGCS) para lactantes y niños con una puntuación inferior a 7 durante más de 24 horas (este criterio no se aplica a niños menores de 1 día de edad). |
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E.5 End points |
E.5.1 | Primary end point(s) |
Response, defined as patients being alive and able to sit upright independently for at least 30 seconds |
Respuesta, definida como un paciente que ha sobrevivido y que puede sentarse erguido de forma autónoma durante al menos 30 segundos en el mes 12 |
|
E.5.1.1 | Timepoint(s) of evaluation of this end point |
|
E.5.2 | Secondary end point(s) |
- Bayley Scales of Infant Development® ? Third Edition (Bayley ? III®) Cognitive and Motor Scales as measured through Month 12
- Functional ability and activities of daily living, measured by the Pediatric Evaluation of Disability Inventory (PEDI) through Month 12 |
-Escalas de Bayley del desarrollo infantil®, tercera edición (Bayley – III) Escalas de la función cognitiva y motora según las mediciones hasta el mes 12
-Capacidad funcional y actividades de la vida cotidiana, medidas por la Evaluación pediátrica del inventario de discapacidad (Pediatric Evaluation of Disability Inventory, PEDI) hasta el mes 12 |
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E.5.2.1 | Timepoint(s) of evaluation of this end point |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | Yes |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | Yes |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | Yes |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | Yes |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | No |
E.8.1.1 | Randomised | No |
E.8.1.2 | Open | Yes |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | No |
E.8.2.4 | Number of treatment arms in the trial | 1 |
E.8.3 |
The trial involves single site in the Member State concerned
| Yes |
E.8.4 | The trial involves multiple sites in the Member State concerned | No |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 12 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | No |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
Canada |
France |
Germany |
Israel |
Italy |
Malaysia |
Netherlands |
Saudi Arabia |
Taiwan |
Tunisia |
Turkey |
United Kingdom |
United States |
|
E.8.7 | Trial has a data monitoring committee | Yes |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
|
|
E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 3 |
E.8.9.1 | In the Member State concerned months | 0 |
E.8.9.1 | In the Member State concerned days | 0 |
E.8.9.2 | In all countries concerned by the trial years | 4 |
E.8.9.2 | In all countries concerned by the trial months | 10 |
E.8.9.2 | In all countries concerned by the trial days | 0 |