Concerned all centres in all countries. Main changes were the following: - Modification of Diet in renal Disease (MDRD) equation noted in the protocol was replaced. - Modification of total amount of blood volume withdrawn over the study (maximum blood volume to be sampled per visit: initially 65 mL brought to 89 mL). - Urinary Albumin/Creatinine Ratio (UACR) conversion factor was updated: 300 mg/g was to be equivalent to 34 mg/mmol, instead of 30 mg/mmol. - Regarding incl/sel criterion and allowed prior/concomitant medications, the Amendment clarified that anti-hyperglycemic medication taken by patients should be at a stable dose for at least 6 weeks prior to selection visit. - The protocol mentionned that ophthalmological examination assessed by fundal examination was to be performed by an ophthalmologist. Following this Amendment it was not required that fundal examinations are to be performed by ophthalmologists only. - At selection (ASS2) visit, new or worsened clinically significant abnormalities noticed during the physical examination should be reported in Medical History instead of being reported as adverse events. - A Section related to "Dialysis during the course of the study" was added in the study protocol for patients suffering from acute kidney injury (AKI) and for patients reaching end-stage renal disease (ESRD) suffering from progressive GFR decline. In addtion, the premature discontinuation criteria were updated accordingly.