E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Late-Infantile Neuronal Ceroid Lipofuscinosis (CLN2). |
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E.1.1.1 | Medical condition in easily understood language |
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E.1.1.2 | Therapeutic area | Diseases [C] - Nervous System Diseases [C10] |
MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 17.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10052074 |
E.1.2 | Term | Neuronal ceroid lipofuscinosis NOS |
E.1.2 | System Organ Class | 100000004850 |
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E.1.3 | Condition being studied is a rare disease | Yes |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
The primary objectives of this study include the following:
•to evaluate the long-term safety of BMN 190 administration at 300 mg qow in patients with CLN2
•to assess change in motor and language subscales of the CLN2 disease rating scale in patients with CLN2 receiving BMN 190 at 300 mg qow
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E.2.2 | Secondary objectives of the trial |
The secondary objectives of the study include the following:
•to assess changes in quantitative assessment of MRI
•to assess change in CLN2 disease scale total score
•to evaluate quality of life (QOL) with long-term BMN 190 administration
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
•Must have completed 48 weeks in Study 190-201
•Is willing and able to provide written, signed informed consent. Or, in the case of patients under the age of 18 (or other age as defined by regional law or regulation), provide written assent (if required) and have written informed consent, signed by a legally authorized representative, after the nature of the study has been explained, and prior to performance of research-related procedures
•If sexually active, must be willing to use an acceptable method of contraception while participating in the study
•If female, of childbearing potential, must have a negative pregnancy test at Baseline and be willing to have additional pregnancy tests done during the study
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E.4 | Principal exclusion criteria |
•Has had a loss of 3 or more points in the combined motor and language components of the Hamburg CLN2 rating scale between Baseline of Study 190-201 and the Study Completion visit in Study 190-201 and would not benefit from enrolling in the study in the Investigator’s discretion
•Has a score of 0 points on the combined motor and language components of the Hamburg CLN2 rating scale
•Is pregnant or breastfeeding, at Baseline, or planning to become pregnant (self or partner) at any time during the study
•Has used any investigational product (other than BMN 190 in 190-201), or investigational medical device, within 30 days prior to Baseline; or is required to use any investigational agent prior to completion of all scheduled study assessments
•Has a concurrent disease or condition that would interfere with study participation, or pose a safety risk, as determined by the Investigator
•Has any condition that, in the view of the Investigator, places the patient at high risk of poor treatment compliance or of not completing the study
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E.5 End points |
E.5.1 | Primary end point(s) |
The primary points of the study include the following:
•to evaluate the long-term safety of BMN 190 administration at 300 mg qow in patients with CLN2
•to assess change in motor and language subscales of the CLN2 disease rating scale in patients with CLN2 receiving BMN 190 at 300 mg qow
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E.5.1.1 | Timepoint(s) of evaluation of this end point |
Patients will complete safety assessments including CSF surveillance labs and a brief physical examination every 2 weeks. Clinical laboratory tests and immunogenicity tests will be performed every 12 weeks. Efficacy per the disease scales will be assessed every 8 weeks. |
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E.5.2 | Secondary end point(s) |
Secondary endpoints of the study include the following:
•to assess changes in quantitative assessment of MRI
•to assess change in CLN2 disease scale total score
•to evaluate quality of life (QOL) with long-term BMN 190 administration
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E.5.2.1 | Timepoint(s) of evaluation of this end point |
MRI and quality of life measures will be collected every 24 weeks. Total score on the disease scales will be assessed every 8 weeks. |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | Yes |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | No |
E.6.7 | Pharmacodynamic | Yes |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | No |
E.8.1.2 | Open | Yes |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | Yes |
E.8.2.3.1 | Comparator description |
External Control (Historical Control) |
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E.8.2.4 | Number of treatment arms in the trial | 1 |
E.8.3 |
The trial involves single site in the Member State concerned
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E.8.4 | The trial involves multiple sites in the Member State concerned | No |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 3 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | No |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
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E.8.7 | Trial has a data monitoring committee | Yes |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 4 |
E.8.9.1 | In the Member State concerned months | 7 |
E.8.9.1 | In the Member State concerned days | |
E.8.9.2 | In all countries concerned by the trial years | 4 |
E.8.9.2 | In all countries concerned by the trial months | 7 |