The highest dose of study agent to be tested was reduced from 90 mg once daily to 60 mg once daily based upon feedback from the FDA; Text on safety margins and adjusted values based upon the change in dose was clarified as appropriate; Screening period expanded to no more than 42 days prior to the first administration of study agent to allow more flexibility for subject screening; To ensure patient safety, a new discontinuation of treatment criterion was added. This criterion stated that all subjects whose postbaseline serum creatinine increase met toxicity Grade 3 and higher based on the Common Terminology Criteria for Adverse Events(CTCAE), version 4.0, were to be discontinued from further study treatment; To establish a baseline triglyceride value, a baseline fasting lipid panel test was added to further assess the risk of increase in triglyceride levels from baseline if needed; Corrections were made to the safety analysis section in statistical methods to summarize number and percentage of subjects by maximum CTCAE grade for each treatment group for each laboratory parameter.