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Clinical trials for Bronchial hyperresponsiveness

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    50 result(s) found for: Bronchial hyperresponsiveness. Displaying page 2 of 3.
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    EudraCT Number: 2011-004966-13 Sponsor Protocol Number: CQAW039A2208 Start Date*: 2011-12-20
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A double-blind, placebo-controlled, study examining the effect of orally administered QAW039 on sputum eosinophil levels and other efficacy outcomes in patients with sputum eosinophilia and pers...
    Medical condition: sputum eosinophilia and moderate-to-severe asthma (GINA 2-5) incompletely controlled on current therapy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10022891 - Investigations 10062305 Sputum eosinophils increased LLT
    14.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003561 Asthma, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-000353-50 Sponsor Protocol Number: CLI-01535AC1-03 Start Date*: 2018-09-21
    Sponsor Name:CHIESI FARMACEUTICI S.p.A
    Full Title: Comparison of two formulations of beclometasone/formoterol pMDI on respiratory system impedance using impulse oscillometry in asthmatic patients.
    Medical condition: Persistent asthma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2005-001466-14 Sponsor Protocol Number: MEN002 Start Date*: 2005-05-26
    Sponsor Name:University of Dundee
    Full Title: A Proof of Concept Study to Investigate the use of Simvastatin as a Putative Anti-inflammatory Agent in Asthma
    Medical condition: Asthma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-005615-26 Sponsor Protocol Number: P05365 Start Date*: 2008-05-30
    Sponsor Name:Schering-Plough Research Institute, a Division of Schering Corporation
    Full Title: Safety of SCH 527123 in Subjects with Neutrophilic Asthma
    Medical condition: Neutrophilic Asthma
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003553 Asthma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GR (Completed) GB (Completed) FR (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-002555-10 Sponsor Protocol Number: ORCA2015 Start Date*: 2015-11-19
    Sponsor Name:Imperial College
    Full Title: Effect of the CRTH2 antagonist OC459 on the response to rhinovirus challenge in asthma
    Medical condition: Asthma
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000015470 10001705 Allergic asthma LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    20.0 100000022885 10049868 Asthma exacerbation prophylaxis LLT
    20.0 100000015470 10003638 Atopic asthma LLT
    20.0 100000015470 10015575 Exacerbation of asthma LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-001209-41 Sponsor Protocol Number: AC-060A201 Start Date*: 2008-07-25
    Sponsor Name:Actelion Pharmaceuticals Ltd
    Full Title: A multi-center, double-blind, placebo-controlled, randomized, multiple dose, 2-period cross-over, Phase IIa study to investigate the pharmacodynamics, tolerability and safety, and pharmacokinetics ...
    Medical condition: Allergic Asthma
    Disease: Version SOC Term Classification Code Term Level
    9.1 10001705 Allergic asthma LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2009-017745-55 Sponsor Protocol Number: 205.424 Start Date*: 2010-05-03
    Sponsor Name:Boehringer Ingelheim Pharma GmbH & Co. KG
    Full Title: A Phase II randomised, double-blind, placebo-controlled, incomplete crossover trial with 4-week treatment periods to evaluate efficacy and safety of tiotropium inhalation solution (doses of 1.25μg,...
    Medical condition: Moderate persistent asthma in adolescents (12 to 17 years old)
    Disease: Version SOC Term Classification Code Term Level
    12.1 10003555 Asthma bronchial LLT
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) SI (Completed) LT (Completed) LV (Completed)
    Trial results: View results
    EudraCT Number: 2009-014415-12 Sponsor Protocol Number: MEA112997 Start Date*: 2010-01-04
    Sponsor Name:GlaxoSmithKline Research & Development Ltd
    Full Title: A multicentre, randomised, double-blind, placebo-controlled, parallel group, dose ranging study to determine the effect of mepolizumab on exacerbation rates in subjects with severe uncontrolled ref...
    Medical condition: severe uncontrolled refractory asthma.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10003553 Asthma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) FR (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2006-003103-39 Sponsor Protocol Number: AR003 Start Date*: 2007-04-19
    Sponsor Name:University of Glasgow & Greater Glasgow Health Board
    Full Title: Effect of statins on asthma control and airway inflammation in smokers with asthma
    Medical condition: Chronic Asthma (smokers),COPD.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10003553 Asthma LLT
    9.1 10010952 COPD LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2021-006691-17 Sponsor Protocol Number: D5180C00024 Start Date*: 2022-07-13
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled 40-week Phase 3 Efficacy and Safety Study of Tezepelumab in Reducing Oral Corticosteroid Use in Adults with Oral Corticosteroid Depend...
    Medical condition: Severe Asthma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-022510-11 Sponsor Protocol Number: MEA114092 Start Date*: 2011-02-23
    Sponsor Name:GlaxoSmithKline Research & Development Ltd
    Full Title: A multicenter, open-label, dose ranging study to determine the pharmacokinetics and pharmacodynamics of mepolizumab administered intravenously or subcutaneously to adult asthmatic subjects with ele...
    Medical condition: Asthma
    Disease: Version SOC Term Classification Code Term Level
    14.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) EE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000164-42 Sponsor Protocol Number: 2016RC01 Start Date*: 2016-08-17
    Sponsor Name:Tayside Medical Sciences Centre on behalf of University of Dundee
    Full Title: JAB02 Repurposing allopurinol as a novel anti-inflammatory treatment for persistent allergic asthma.
    Medical condition: Asthma
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10001705 Allergic asthma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-006469-17 Sponsor Protocol Number: 2006-001 Start Date*: Information not available in EudraCT
    Sponsor Name:St Olavs Hospital, University Hospital of Trondheim [...]
    1. St Olavs Hospital, University Hospital of Trondheim
    2. Haukeland University Hospital
    Full Title: A multicenter study to investigate the Sensitivity and Specificity of Aridol (Mannitol)Challenge as compared with Methacholine Challenge to predict a diagnosis of Asthma by a Specialist Pulmonologi...
    Medical condition: The detection of bronchial hyperresponsiveness in patients with suspected asthma
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004424-29 Sponsor Protocol Number: 6727 Start Date*: 2018-03-23
    Sponsor Name:Academic Medical Center
    Full Title: Pharmacogenetics Use For Further treatment Improvement in childreN (PUFFIN) trial
    Medical condition: Children with persistent uncontrolled asthma
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000548-29 Sponsor Protocol Number: ADA103575 Start Date*: 2007-05-04
    Sponsor Name:GlaxoSmithKline R&D
    Full Title: A Multicenter, Randomized, Double-Blind, Triple-Dummy, Placebo-Controlled, Parallel Group, Four-Week Study Assessing the Efficacy of Fluticasone Propionate Aqueous Nasal Spray 200mcg OD versus Mont...
    Medical condition: Persistent asthma and seasonal allergic rhinitis.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003553 Asthma LLT
    9.1 10039776 Seasonal allergic rhinitis LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: EE (Completed) FI (Prematurely Ended) PL (Ongoing)
    Trial results: View results
    EudraCT Number: 2005-005615-21 Sponsor Protocol Number: 205.341 Start Date*: 2006-07-13
    Sponsor Name:Boehringer Ingelheim Pharma GmbH & Co. KG
    Full Title: A Randomised, Double-Blind, Placebo-Controlled, Crossover Efficacy and Safety Evaluation of 8-Week Treatment Periods of Two Doses [5 µg (2 actuations of 2.5 µg) and µg (2 actuations of 5 µg)] of Ti...
    Medical condition: Patients with severe persistent asthma
    Disease: Version SOC Term Classification Code Term Level
    8.1 10003555 Asthma bronchial LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2007-001345-18 Sponsor Protocol Number: HZA109912 Start Date*: 2007-07-26
    Sponsor Name:GlaxoSmithKline Research & Development Limited
    Full Title: A 19-week, randomized, double-blind, placebo-controlled, three-period, cross-over pilot study comparing the effect of salmeterol/fluticasone propionate 50/100mcg BID, fluticasone propionate 100mcg ...
    Medical condition: Asthma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-001729-28 Sponsor Protocol Number: IPI-145-03 Start Date*: 2012-07-17
    Sponsor Name: Infinity Pharmaceuticals, Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Multi-Dose, Cross-Over, Efficacy and Safety Study of IPI-145 in Mild Asthmatic Subjects Undergoing Allergen Challenge
    Medical condition: Mild asthma with allergen challenge
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10003561 Asthma, unspecified LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-001607-23 Sponsor Protocol Number: EFC14153 Start Date*: 2017-06-30
    Sponsor Name:Sanofi-Aventis Recherche & Développement
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Dupilumab in Children 6 to <12 Years of Age with Uncontrolled Persistent Asthma
    Medical condition: Asthma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10003553 Asthma PT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) LT (Completed) PL (Completed) ES (Completed) Outside EU/EEA IT (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2012-005350-39 Sponsor Protocol Number: 20122011 Start Date*: 2013-04-22
    Sponsor Name:University Medical Centre Groningen
    Full Title: Effects Of extra-fine particle HFA-becLomethasone (HFA-QVAR) Versus course particle treatment In smokers and ex-smokers with Asthma
    Medical condition: Asthma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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