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Clinical trials for Melatonin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44351   clinical trials with a EudraCT protocol, of which   7378   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    82 result(s) found for: Melatonin. Displaying page 2 of 5.
    « Previous 1  2  3  4  5  Next»
    EudraCT Number: 2014-003789-25 Sponsor Protocol Number: mela1 Start Date*: 2015-02-26
    Sponsor Name:Department of surgery, Herlev Hospital
    Full Title: The anxiolytic effects of melatonin: A randomized, placebo-controlled, double-blinded clinical study.
    Medical condition: We intend to investigate the anxiolytic effects of melatonin in relation to surgery.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10002855 Anxiety PT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-004183-21 Sponsor Protocol Number: 2858 Start Date*: 2013-01-25
    Sponsor Name:North Bristol NHS Trust
    Full Title: A randomized, double blind, placebo controlled, cross over trial of Melatonin for the treatment of nocturia in adults with progressive multiple sclerosis, with an open label, single-arm extension s...
    Medical condition: Nocturia; Multiple Sclerosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006464-24 Sponsor Protocol Number: 20211125 Start Date*: 2022-12-14
    Sponsor Name:Rigshospitalet, Department of Anesthesiology, Juliane Marie Center
    Full Title: Intravenous MELAtonin for prevention of Postoperative Agitation and Emergence Delirium in children. The MELA-PAED trial: a randomized, double-blind, placebo-controlled clinical trial.
    Medical condition: Emergence delirium Postoperative agitation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10050233 Delirium on emergence LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-002189-39 Sponsor Protocol Number: 161802 Start Date*: 2017-12-11
    Sponsor Name:University of Oxford
    Full Title: A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease.
    Medical condition: circadian sleep-wake disturbances associated with ocular disease.
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029205 - Nervous system disorders 10009191 Circadian rhythm sleep disorder PT
    21.1 10029205 - Nervous system disorders 10009191 Circadian rhythm sleep disorder PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2008-004740-36 Sponsor Protocol Number: MINT (CRO1834) Start Date*: 2011-08-04
    Sponsor Name:Imperial College, London
    Full Title: Melatonin As A Novel Neuroprotectant In Preterm Infants−Trial Study
    Medical condition: Brain injury from prematurity
    Disease: Version SOC Term Classification Code Term Level
    14.0 10036585 - Pregnancy, puerperium and perinatal conditions 10013384 Disorders relating to short gestation and unspecified low birthweight LLT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-002436-82 Sponsor Protocol Number: EC11-441 Start Date*: 2012-12-13
    Sponsor Name:Isabel Pinilla Lozano
    Full Title: Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa
    Medical condition: To evaluate the sleep quality in patients with Retinitis Pigmentosa
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-000184-24 Sponsor Protocol Number: EC11-222 Start Date*: Information not available in EudraCT
    Sponsor Name:ANTONIO JEREZ CALERO
    Full Title: Whole body hypothermia + melatonin vs whole body hypothermia + placebo in asphyctic newborns. A multicentric, ramdomized, controlled and double blind clinical trial
    Medical condition: Hipothermia plus melatonine neuroprotection terapy in asphixiated newborns.
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003955-23 Sponsor Protocol Number: DR2 Start Date*: 2016-04-15
    Sponsor Name:Dept. of Ophthalmology, Rigshospitalet – Glostrup
    Full Title: Diabetic retinopathy: Effects of melatonin treatment on visual functions and circadian rhythm.
    Medical condition: Diabetic Retinopathy and Sleep disorder
    Disease: Version SOC Term Classification Code Term Level
    20.1 10015919 - Eye disorders 10012689 Diabetic retinopathy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2007-004664-46 Sponsor Protocol Number: melmet Start Date*: 2008-07-29
    Sponsor Name:No Sponsor
    Full Title: Influence of methylphenidate on sleep and circadian rhythm in children with Attention-Deficit/Hyperactivity Disorder (ADHD)
    Medical condition: Sleep disorders in Attention-Deficit/ Hyperactivity Disorder (ADHD)
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000211-80 Sponsor Protocol Number: 18024 Start Date*: 2019-08-26
    Sponsor Name:Child and adolescent Psychiatry, South Jutland
    Full Title: Melatonin – production and release in children and adolescents with ADHD and chronic sleep problems
    Medical condition: Attention Deficit Hyperactivity Disorder and Sleep Problems
    Disease: Version SOC Term Classification Code Term Level
    23.0 100000004873 10003735 Attention deficit-hyperactivity disorder LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-000205-23 Sponsor Protocol Number: 14012013 Start Date*: 2013-03-27
    Sponsor Name:Department of surgery, Herlev Hospital
    Full Title: The analgesic effects of melatonin: A randomized, placebo-controlled, double-blinded study on healthy volunteers
    Medical condition: Heat injury in healthy volunteers
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004863 10054711 Postoperative pain LLT
    16.0 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001534-13 Sponsor Protocol Number: JAN13004-30 Start Date*: 2015-10-02
    Sponsor Name:SPHERIUM BIOMED S.L.
    Full Title: Phase IB-II clinical trial of melatonin oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing chemoradiation.
    Medical condition: Oral mucositis in patients with head and neck cancer undergoing chemoradiation
    Disease: Version SOC Term Classification Code Term Level
    18.0 10022117 - Injury, poisoning and procedural complications 10037763 Radiation mucositis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000991-13 Sponsor Protocol Number: STH19610 Start Date*: Information not available in EudraCT
    Sponsor Name:Sheffield Teaching Hospitals NHS Foundation Trust
    Full Title: The MAGIC trial (Melatonin for Anxiety prior to General anaesthesia In Children): A Multicentre, Parallel Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious C...
    Medical condition: Anxiety pre-general anaesthesia
    Disease: Version SOC Term Classification Code Term Level
    20.0 10037175 - Psychiatric disorders 10002869 Anxiety symptoms HLT
    20.1 10022117 - Injury, poisoning and procedural complications 10054711 Postoperative pain LLT
    20.1 10022117 - Injury, poisoning and procedural complications 10049989 Agitation postoperative PT
    20.0 10037175 - Psychiatric disorders 10002855 Anxiety PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2011-000991-33 Sponsor Protocol Number: PI10/02877 Start Date*: 2012-07-13
    Sponsor Name:Instituto Aragonés de Ciencias de la Salud
    Full Title: Impact of melatonin in the pretreatment of organ donor and the influence in the evolution of liver transplant: a prospective, randomised double-blind study.
    Medical condition: Organ Transplant
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-000996-57 Sponsor Protocol Number: MAPLE A Start Date*: 2009-04-01
    Sponsor Name:Academic Medical Centre
    Full Title: The effects of melatonin the occurence of on post-operative delirium in hip fracture patients – a randomized double-blind placebo controlled trial
    Medical condition: Delirium in elderly patients, acutely admitted for hip-fracture.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012218 Delirium LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005895-37 Sponsor Protocol Number: ASP-MEL-CT001 Start Date*: 2021-08-03
    Sponsor Name:Aspire Pharma Limited
    Full Title: An open label one-treatment, one-period, one-sequence, single oral dose bioavailability study for Melatonin in healthy, adult, human subjects under fasting conditions.
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10023190 Jet lag LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: HR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-003796-37 Sponsor Protocol Number: MELMIS Start Date*: 2005-01-26
    Sponsor Name:Dept. of surg.gastroent., Gentofte University Hospital, Copenhagen
    Full Title: Effekt af melatonin på forekomsten af postoperativ træthed og søvnforstyrrelser efter laparoskopisk kolecystektomi. En randomiseret dobbelt-blindet placebo kontrolleret undersøgelse.
    Medical condition: postoperativ fatigue og søvnforstyrrelser
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002116-32 Sponsor Protocol Number: MTM-04 Start Date*: 2015-09-23
    Sponsor Name:Køge Hospital
    Full Title: The effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep disturbances in patients after acute myocardial syndrome
    Medical condition: Depression Anxiety Sleep disturbances Circadian disturbances
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004852 10009190 Circadian dysrhythmia LLT
    19.0 100000004873 10002865 Anxiety reaction LLT
    19.0 100000004873 10040999 Sleep disturbed LLT
    19.0 100000004873 10012402 Depressive episode LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2010-022400-53 Sponsor Protocol Number: NLH-01 Start Date*: 2011-01-13
    Sponsor Name:Køge Hospital
    Full Title: Intracoronary administration of melatonin for patients with acute myocardial infarction: a placebo controlled randomized study.
    Medical condition: Acute Myocardial Infarction
    Disease: Version SOC Term Classification Code Term Level
    18.1 10007541 - Cardiac disorders 10000891 Acute myocardial infarction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2010-024018-71 Sponsor Protocol Number: 2010-024018-71 Start Date*: 2011-03-31
    Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA
    Full Title: PREMEDICATION IN CHILDREN: CLONIDINE VERSUS MELATONIN
    Medical condition: HEALTHY CHILDREN UNDERGOING ELECTIVE MINOR SURGERY
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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