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Clinical trials for Opioids

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44356   clinical trials with a EudraCT protocol, of which   7382   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    356 result(s) found for: Opioids. Displaying page 2 of 18.
    « Previous 1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2021-001238-21 Sponsor Protocol Number: 2020-SESGEN Start Date*: 2021-07-06
    Sponsor Name:Institute of Health and Biomedical Research of Alicante
    Full Title: Gender biases in pain medicine: from omics to healthcare.
    Medical condition: The medical condition to be evaluated is the analgesic response of people with chronic low back pain who are going to be treated with opioids, guided by omics sciences (pharmacogenetics, epigeneti...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-002618-38 Sponsor Protocol Number: AnesBar01 Start Date*: 2013-10-15
    Sponsor Name:
    Full Title: Does preperitoneal local anesthesia in laparoscopic gastric bypass surgery reduce postoperative pain and opioid consumption?
    Medical condition: Postoperative pain
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004863 10054711 Postoperative pain LLT
    16.0 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2016-002379-89 Sponsor Protocol Number: AGO/2016/007 Start Date*: 2016-09-18
    Sponsor Name:Ghent University Hospital
    Full Title: Treatment of acute locomotoric pain in the geriatric patient: comparison of effectiveness and safety between step 2 (weak opioids) and step 3 (strong opioids) pain relief of the WHO-ladder.
    Medical condition: Acute locomotoric pain in the geriatric patient.
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-003091-39 Sponsor Protocol Number: APHP180158 Start Date*: 2020-02-10
    Sponsor Name:Assistance Publique des Hôpitaux de Paris
    Full Title: To relieve dyspnea with low dose titration of morphine in patients admitted to intensive care for acute respiratory failure: A pilot study - OPIDYS
    Medical condition: Adult patients admitted to intensive care for ARI: severe dyspnea (defined by a visual analogue dyspnea scale (EVA-dyspnea) ≥ 40)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000805-32 Sponsor Protocol Number: 2911 Start Date*: 2007-04-03
    Sponsor Name:The Royal Marsden NHS Foundation Trust
    Full Title: AN INVESTIGATION INTO THE ROLE OF PARACETAMOL (ACETAMINOPHEN) AT STEP 3 OF THE WHO ANALGESIC LADDER
    Medical condition: The management of cancer pain in patients on step 3 of the WHO analgesic ladder, ie patients on a regular opioids for moderate to severe pain and paracetamol.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-008919-26 Sponsor Protocol Number: S-20080152 Start Date*: 2009-02-06
    Sponsor Name:Orthopaedic research unit. Odense University Hospital
    Full Title: Postoperative Analgesia With Local Infiltration After Periacetabular Osteotomy For The Treatment Of Dysplasia
    Medical condition: Pain treatment after periacetabular osteotomy is traditionally based on systemic opioids wich have side effects. The purpose of this study is to evaluate the analgetic effect of wound infiltration ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000396 Acetabular dysplasia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-002130-23 Sponsor Protocol Number: TQLnephrectomi_v_1 Start Date*: 2017-07-28
    Sponsor Name:Zealand university hospital Roskilde
    Full Title: Ultrasoundguided Transmuscular Quadratus Lumborum(TQL) block for hand assisted laparoscopic nephrectomy - a randomized controlled trial
    Medical condition: The postoperative pain after Hand assisted lap.nephrectomy operation.Our one year retrospective study of patients with Kidney cancer treated with Hand assisted lap.nephrectomy revealed that, 71% of...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-003577-25 Sponsor Protocol Number: 1907V921F Start Date*: Information not available in EudraCT
    Sponsor Name:Shionogi B.V.
    Full Title: A Phase 1/2, Multicentre, Open-label Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Naldemedine in Paediatric Patients Who Are Receiving or Who Are About to Receive Treatment w...
    Medical condition: Opioid induced constipation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) FR (Completed) HU (Prematurely Ended) IT (Completed) NL (Prematurely Ended) BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002520-18 Sponsor Protocol Number: MRZ 92579 – 0405/1 Start Date*: 2005-03-15
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: Safety and efficacy of Neramexane mesylate as add-on therapy to opioids in cancer patients for the management of chronic pain attributable to skeletal metastases: A randomised, double-blind, placeb...
    Medical condition: Moderate to severe chronic pain (cancer pain)
    Disease: Version SOC Term Classification Code Term Level
    7.1 10058019 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-000180-81 Sponsor Protocol Number: SLT4501 Start Date*: 2013-09-20
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: A single-arm, open-label, multicentre, non-randomised, study to assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in s...
    Medical condition: Assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in subjects suffering from malignant or non-malignant pain that requi...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2004-004624-13 Sponsor Protocol Number: PRG-BUP-04/02 Start Date*: 2005-05-31
    Sponsor Name:Barts and The London NHS Trust
    Full Title: A prospective, multi-centre, open-label study to establish the equipotent dose ratio after switching from strong opioids to Transtec® in subjects with pain due to cancer
    Medical condition: cancer pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) AT (Prematurely Ended) DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-009856-19 Sponsor Protocol Number: 42160443PAI2004AmINT-2 Start Date*: 2009-12-17
    Sponsor Name:Janssen-Cilag International NV
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 as Adjunctive Therapy in Subjects With Moderate to Severe Knee ...
    Medical condition: moderate to severe, chronic, knee or hip pain from osteoarthritis (OA) that is not adequately controlled by standard pain therapy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10023477 Knee pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-009377-10 Sponsor Protocol Number: NAL-OIC-01 Start Date*: 2009-05-27
    Sponsor Name:SLA Pharma (UK) Ltd
    Full Title: A Multicenter, Randomised, Double-Blind, Placebo-Controlled, Multiple Ascending Dose, Safety, Tolerability and Efficacy Study of Naloxone SR capsules in Subjects with Constipation due to Opioids ta...
    Medical condition: Opioid Induced Constipation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021175 Iatrogenic constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-005797-32 Sponsor Protocol Number: Uni-Koeln-1412 Start Date*: 2013-02-28
    Sponsor Name:University of Cologne
    Full Title: Effentora® for Dyspnoea (EffenDys) - Fentanyl buccal tablet (FBT) for the relief of episodic dyspnoea (ED) in cancer patients: an open label, randomized, morphine-controlled, crossover, phase II trial
    Medical condition: Patients with cancer suffering from episodes of dyspnoea (ED)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-005489-46 Sponsor Protocol Number: OPEGG Start Date*: 2016-02-02
    Sponsor Name:Umeå University
    Full Title: Recovery of gastric function after treatment with shortacting opioids.
    Medical condition: The effect of opioids on gastric electrical activity
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004856 10018043 Gastroparesis LLT
    18.1 10022117 - Injury, poisoning and procedural complications 10018044 Gastroparesis postoperative PT
    18.1 100000004856 10021227 Idiopathic gastroparesis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-004797-33 Sponsor Protocol Number: Obstetrics1.0 Start Date*: 2018-06-13
    Sponsor Name:CHU Tivoli
    Full Title: The efficacy of continuous ropivacaine wound infusion after cesarean delivery in pain management.
    Medical condition: Poor postoperative pain control leads to decreased satisfaction with care, prolonged recovery time and increased use of health care resources. Despite their efficacy, opioids are associated with na...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001782-18 Sponsor Protocol Number: MRZ 92579-0404/1 Start Date*: 2005-02-14
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: Saftey and efficacy of two different doses of Neramexane mesylate as preemptive analgesic and add-on therapy to opioids in the management of postoperative pain. A randomised, double-blind, placebo-...
    Medical condition: Moderate to severe acute postoperative pain
    Disease: Version SOC Term Classification Code Term Level
    7.1 10054711 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2013-001540-60 Sponsor Protocol Number: MULTIPAIN6-2013 Start Date*: 2013-08-08
    Sponsor Name:Mech-Sense, Aalborg University Hospital
    Full Title: A novel approach to assess gastrointestinal adverse effects of opioids
    Medical condition: Opioid-induced bowel dysfunction.
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2009-010360-41 Sponsor Protocol Number: BU0902 Start Date*: 2009-06-03
    Sponsor Name:Reckitt Benckiser Healthcare (UK) Limited
    Full Title: A multicentre, randomised, open-label, active-controlled trial of the effectiveness of buprenorphine/naloxone in reducing intravenous buprenorphine misuse in France
    Medical condition: For both compounds, substitution treatment for opioid drug dependence, adult subjects with a diagnosis of major heroin dependence. Only for Suboxone, the intention of naloxone is to deter the intra...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012346 Dependence on opiates LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2019-000959-14 Sponsor Protocol Number: 29BRC18.0262 Start Date*: 2021-03-16
    Sponsor Name:CHRU de Brest
    Full Title: The NIPA study: A randomized double-blind control clinical trial Naloxegol administration to prevent opioids induced gastrointestinal motility disturbance in brain Injured PAtients.
    Medical condition: Prevent opioids induced gastrointestinal motility disturbance in brain Injured Patients.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10061173 Gastrointestinal motility disorder PT
    21.1 10029205 - Nervous system disorders 10042316 Subarachnoid haemorrhage PT
    20.0 100000004863 10078809 Skull trauma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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