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Clinical trials for Total Knee Replacement

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    The EU Clinical Trials Register currently displays   44349   clinical trials with a EudraCT protocol, of which   7376   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    107 result(s) found for: Total Knee Replacement. Displaying page 3 of 6.
    « Previous 1  2  3  4  5  6  Next»
    EudraCT Number: 2019-002451-42 Sponsor Protocol Number: URANO Start Date*: 2019-10-22
    Sponsor Name:IRCCS ISTITUTO CLINICO HUMANITAS
    Full Title: nd
    Medical condition: Patients undergoing total knee replacement surgery with spinal anesthesia.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10049548 Knee operation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002245-21 Sponsor Protocol Number: SM1-JKS-14 Start Date*: 2014-07-02
    Sponsor Name:Ulrik Grevstad
    Full Title: Effect of adductor canal block vs. placebo on muscle strength, mobilisation and pain on the first post-operative day after total knee athroplasty
    Medical condition: Treatment of post-operative pain after total knee athroplasty
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-002449-12 Sponsor Protocol Number: 2013-002449-12 Start Date*: 2013-11-19
    Sponsor Name:Westfriesgasthuis
    Full Title: Does buprenorphine (Temgesic) 0,3 mg prolongs the analgesic effect of a blockade of the femoral nerve with 20 ml ropivacaïne HCL Fresenius Kabi 0,2% for patiënts with a total knee replacement. A pr...
    Medical condition: -
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000071-24 Sponsor Protocol Number: TRANEXTIME Start Date*: 2016-03-10
    Sponsor Name:Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR)
    Full Title: TIME OF ADMINISTRATION OF TRANEXAMIC ACID TO PREVENT BLEEDING IN TOTAL KNEE ARTHROPLASTY
    Medical condition: Total knee arthroplasty bleeding
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-004554-28 Sponsor Protocol Number: SM3_UG_12 Start Date*: 2012-12-18
    Sponsor Name:Rigshospitalet
    Full Title: Effect of Adductor-Kanal-Blokade vs femoralis-Blokade on muskelstyrke, mobility and smerter with high smerte responders 1. and 2. postoperative day after total knæalloplastik
    Medical condition: Treatment of postoperative pain after a total knee replacement
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018723-26 Sponsor Protocol Number: 1160.86 Start Date*: 2010-07-15
    Sponsor Name:Boehringer Ingelheim Finland Ky
    Full Title: An open label, non-comparative, pharmacokinetic and pharmacodynamic study to evaluate the effect of Dabigatran Etexilate on coagulation parameters including a calibrated thrombin time test in patie...
    Medical condition: Primary VTE prevention in patients with moderate renal impairment (Creatinine Clearance 30-50 ml/min) following total hip or knee replacement surgery
    Disease: Version SOC Term Classification Code Term Level
    12.1 10049909 Venous thromboembolism prophylaxis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) AT (Completed) SE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-003408-21 Sponsor Protocol Number: THO-IM_02-CT Start Date*: 2015-12-09
    Sponsor Name:Thrombotargets Europe
    Full Title: A Phase II/III, randomized, controlled, single blind study to evaluate the haemostatic efficacy and safety of topically applied TT-173 in patients undergoing knee arthroplasty
    Medical condition: Haemostatic effect in patients undergoing knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004865 10060663 Surgical hemostasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000295-94 Sponsor Protocol Number: TPO-150 Start Date*: 2015-10-13
    Sponsor Name:St Olavs University Hospital
    Full Title: Use of long acting opioids for pre- and postoperative analgesia in primary total knee arthroplasty. A double-blinded randomized control trial. Tapentadol vs Oxycodon vs Placebo
    Medical condition: Pain therapy for total knee arthroplasty (total knee replacement)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004863 10036286 Post-operative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2014-003343-35 Sponsor Protocol Number: CR-TFB-2014/502 Start Date*: 2014-10-01
    Sponsor Name:Thomas Fichtner Bendtsen
    Full Title: The effect of saphenous nerve and obturator nerve block combined with systemic high dose glucocorticoid versus local infiltration analgesia combined with a systemic high dose glucocorticoid on opi...
    Medical condition: The medical condition to be examined in this study is the first postoperative period after total knee replacement with a view to pain management.
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2016-000082-23 Sponsor Protocol Number: 2016-001-M Start Date*: 2016-03-11
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Median Local Anaesthetic Dose (MLAD) of intrathecal Bupivacaine in total knee arthroplasty
    Medical condition: Spinal anaesthesia during total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002769-72 Sponsor Protocol Number: SM1-DHAG-2016 Start Date*: 2016-08-29
    Sponsor Name:Næstved Hospital
    Full Title: DEXRAR: DEXamethasone in Revision ARthroplasty: A randomised, blinded, 2-group clinical trial
    Medical condition: Pain after revision surgery after total knee replacement
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10057129 Revision of total knee arthroplasty LLT
    19.0 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-004313-41 Sponsor Protocol Number: 47659 Start Date*: 2014-05-19
    Sponsor Name:UMCG
    Full Title: Effect of pre-operative pain treatment by means of duloxetine on postoperative outcome after total hip or knee arthroplasty
    Medical condition: Osteoarthritis (knee or hip)
    Disease: Version SOC Term Classification Code Term Level
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-001943-12 Sponsor Protocol Number: R475-PN-1612 Start Date*: 2018-05-22
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Fasinumab in Patients with Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hi...
    Medical condition: Pain due to osteoarthritis and chronic lower back pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) HU (Prematurely Ended) ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-013817-93 Sponsor Protocol Number: 2190 Start Date*: 2009-08-27
    Sponsor Name:North Bristol NHS Trust, Research and Development
    Full Title: Arthroplasty Pain Experience Study (APEX): A randomised controlled trial to determine if local wound infiltration reduces chronic pain after lower limb arthroplasty.
    Medical condition: hip and knee osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2015-005179-25 Sponsor Protocol Number: 402-C-326 Start Date*: 2016-06-10
    Sponsor Name:Pacira Pharmaceuticals, Inc.
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block with EXPAREL for Postsurgical Analgesia in Subjects Un...
    Medical condition: Total Knee Arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2022-003885-19 Sponsor Protocol Number: NOT-APPLICABLE-HUFA Start Date*: 2023-03-15
    Sponsor Name:NO-COMERCIAL
    Full Title: ECOGUIDED GENICULAR NERVE BLOCK IN PATIENTS WITH KNEE OSTEOARTHRITIS BY LOCAL ANESTHETIC OR BY COMBINATION OF LOCAL ANESTHETIC AND CORTICOID: PLACEBO-CONTROLLED RANDOMIZED BLIND CLINICAL TRIAL
    Medical condition: KNEE OSTEOARTHRITIS
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-006896-19 Sponsor Protocol Number: CV185-047 Start Date*: 2007-09-06
    Sponsor Name:Bristol Myers Squibb International Corporation
    Full Title: A Phase 3, Randomized, Double-blind, Active-controlled (Enoxaparin 40 mg QD), Parallel-group, Multi-center Study to Evaluate the Safety and Efficacy of Apixaban in Subjects Undergoing Elective Tota...
    Medical condition: Venous Thromboembolic Events
    Disease: Version SOC Term Classification Code Term Level
    9.1 10043565 Thromboembolic event LLT
    9.1 10051055 Deep vein thrombosis LLT
    9.1 10037377 Pulmonary embolism LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) ES (Completed) NL (Completed) AT (Completed) BE (Completed) FR (Completed) HU (Completed) SE (Completed) IT (Completed) CZ (Completed) DK (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-005443-23 Sponsor Protocol Number: FEMTIB2020 Start Date*: 2021-06-21
    Sponsor Name:Hospital Sant Joan de Reus
    Full Title: Comparative study between two ultrasound-guided peripheral blocks for postoperative analgesia of primary total knee arthroplasty
    Medical condition: Patients undergoing knee replacement
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001048-32 Sponsor Protocol Number: 0701017 Start Date*: 2008-09-15
    Sponsor Name:CHU SAINT-ETIENNE
    Full Title: Prospective, multicentre, open-label study evaluating Fondaparinux (1,5 mg/day) in venous thromboembolic events prevention in patients with renal impairment defined by a creatinin clearance between...
    Medical condition: Patients with renal impairment defined by a creatinin clearance between 20 and 50 ml/min and undergoing a major orthopaedic surgery (hip fracture, total hip replacement and total knee replacement)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10038474 Renal insufficiency LLT
    9.1 10020100 Hip fracture LLT
    9.1 10023476 Knee osteoarthritis LLT
    9.1 10049909 Venous thromboembolism prophylaxis LLT
    9.1 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000857-10 Sponsor Protocol Number: NA Start Date*: 2022-05-16
    Sponsor Name:CHU de Liège
    Full Title: Isobaric versus hyperbaric intrathecal bupivacaine: influence of baricity on blood pression variation during elective total knee arthroplasty: a randomized clinical trial.
    Medical condition: Total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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