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Clinical trials for Levels of biomarkers

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44381   clinical trials with a EudraCT protocol, of which   7393   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,170 result(s) found for: Levels of biomarkers. Displaying page 4 of 59.
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    EudraCT Number: 2019-002643-23 Sponsor Protocol Number: STH19966 Start Date*: 2020-03-23
    Sponsor Name:Sheffield Teaching Hospitals NHS Foundation Trust
    Full Title: Validation of a novel composite of skin biomarkers as a primary outcome measure for evaluating the safety of treatments for atopic dermatitis: a randomized controlled trial (phase 2) comparing the ...
    Medical condition: atopic eczema (synonym atopic dermatitis) and the adverse treatment side effect epidermal atrophy
    Disease: Version SOC Term Classification Code Term Level
    21.1 10040785 - Skin and subcutaneous tissue disorders 10003641 Atopic eczema LLT
    21.0 10040785 - Skin and subcutaneous tissue disorders 10040799 Skin atrophy PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2012-005416-26 Sponsor Protocol Number: ANSWER Start Date*: 2014-06-06
    Sponsor Name:Mario Negri Institute
    Full Title: A Prospective, Randomized, Open, Blinded Endpoint (PROBE), Clinical Trial to Assess The Renal and Humoral Effects of Sevelamer Carbonate in Patients with Chronic Kidney Disease and Residual Protein...
    Medical condition: Chronic Kidney Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2013-003478-29 Sponsor Protocol Number: VIDAFACT Start Date*: 2014-03-21
    Sponsor Name:Maria Nabal Vicuña (Paliative Care Supportive Team-Hospital Universitari Arnau de Vilanova de Lleida)
    Full Title: The effect on quality of life of Vitamin D administration for advanced cancer treatment. A randomized controlled trial
    Medical condition: The effect on quality of life of Vitamin D administration for advanced cancer treatment. A randomized controlled trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004624-30 Sponsor Protocol Number: TOC17_01 Start Date*: 2018-05-16
    Sponsor Name:Linköping University
    Full Title: Modulating proinflammatory processes using tocilizumab in major depressive disorder
    Medical condition: Major depressive disorder
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2021-003299-15 Sponsor Protocol Number: METFORAGING Start Date*: 2021-10-19
    Sponsor Name:Fundación para la Investigación Biomédica del Hospital La Paz
    Full Title: A double blinded, phase II, placebo controlled, single center randomized clinical trial to evaluate metformin compared with placebo for reversal of accelerated biological aging in persons living wi...
    Medical condition: Patients with HIV and accelerated biological aging
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-006176-16 Sponsor Protocol Number: I5Q-NS-O001 Start Date*: 2022-09-26
    Sponsor Name:Charité - Universitätsmedizin Berlin
    Full Title: Definition of neuroimaging and laboratory biomarkers as possible predictors for treatment response to Galcanezumab in high-frequency episodic migraine (PREDICT)
    Medical condition: High-frequency episodic migraine.
    Disease: Version SOC Term Classification Code Term Level
    22.0 100000004852 10082019 Episodic migraine LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2014-003455-61 Sponsor Protocol Number: 2013GR06 Start Date*: 2015-02-11
    Sponsor Name:Tayside Academic Sciences Centre
    Full Title: Perindopril and Leucine to improve muscle function in older people
    Medical condition: Sarcopenia
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10063024 Sarcopenia PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-002886-21 Sponsor Protocol Number: UC-0110/1809 Start Date*: 2018-12-11
    Sponsor Name:UNICANCER
    Full Title: A Phase III randomized study evaluating gemcitabine and paclitaxel versus gemcitabine alone after FOLFIRINOX failure or intolerance in Metastatic Pancreatic Ductal Adenocarcinoma.
    Medical condition: Metastatic Pancreatic Ductal Adenocarcinoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2016-005083-34 Sponsor Protocol Number: CAPI2017NL10 Start Date*: 2017-08-23
    Sponsor Name:University Medical Center Utrecht
    Full Title: Conestat alfa as prophylactic treatment for idiopathic non-histaminergic acquired angioedema
    Medical condition: The medical condition to be investigated is idiopathic non-histaminergic angioedema (InH-AAE). This disease is characterized by recurrent episodes with swelling of the subcutis and mucous membranes...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-020783-38 Sponsor Protocol Number: VB-201-030 Start Date*: 2010-09-29
    Sponsor Name:Vascular Biogenics Ltd
    Full Title: A Phase II, Randomised, Double blind, Placebo-Controlled, Dose-Ranging Study to Assess the Effect of Multiple Doses of VB-201 on Biomarkers of Inflammation, Safety and Pharmacokinetics in Subjects ...
    Medical condition: elevated hsCRP and other biomarkers for inflammation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-002269-21 Sponsor Protocol Number: 01.00240 Start Date*: 2013-12-06
    Sponsor Name:Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto
    Full Title: Metformin in diastolic dysfunction of metabolic syndrome
    Medical condition: Diastolic dysfunction in non-diabetic patients with metabolic syndrome
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002858-20 Sponsor Protocol Number: ESR-15-11561-61/DUNE Start Date*: 2017-03-02
    Sponsor Name:GETNE (Grupo Español de Tumores Neuroendocrinos)
    Full Title: A phase II study of durvalumab (MEDI4736) plus tremelimumab for the treatment of patients with advanced neuroendocrine neoplasms of gastroenteropancreatic or lung origin (the DUNE trial).
    Medical condition: Advanced neuroendocrine neoplasms of gastroenteropancreatic or lung origin.
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004864 10062476 Neuroendocrine tumor LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2005-001556-20 Sponsor Protocol Number: SB-480848/026 Start Date*: 2005-11-01
    Sponsor Name:GlaxoSmithKline Research & Development Limited
    Full Title: Integrated Biomarker and Imaging Study – 2 (IBIS-2)
    Medical condition: SB-480848 is under developement as a potential anti-atherosclerosis agent for reduction of major cardiovascular events in high risk patient populations.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) CZ (Completed) DE (Completed) AT (Completed) DK (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2008-003972-23 Sponsor Protocol Number: hcc1 Start Date*: 2009-01-09
    Sponsor Name:LUMC
    Full Title: Hepatocellular carcinoma: vascular abnormalities prior to, during and following systemic anti-cancer treatment
    Medical condition: The primary objective of this study is to determine the efficacy of the combination of everolimus and capecitabine in a group of patients with metastatic or locally advanced HCC. In addition, to in...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019828 Hepatocellular carcinoma non-resectable LLT
    9.1 10019829 Hepatocellular carcinoma recurrent LLT
    9.1 10008452 Chemotherapy multiple agents systemic LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000270-36 Sponsor Protocol Number: AbiCab Start Date*: 2015-05-07
    Sponsor Name:Umeå University Hospital
    Full Title: A randomized Phase II, open label multicenter cross-over study, to evaluate biomarkers, in 2nd line treatment of metastatic Castration Resistant Prostate Cancer (mCRPC) with abiraterone and cabazit...
    Medical condition: Metastatic Castration Resistant Prostate Cancer
    Disease: Version SOC Term Classification Code Term Level
    17.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10036909 Prostate cancer metastatic PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2021-002687-41 Sponsor Protocol Number: TA-8995-AD-1 Start Date*: 2021-12-09
    Sponsor Name:NewAmsterdam Pharma BV
    Full Title: A Phase 2a, Proof-of-Concept, Open-Label Study to Evaluate the Pharmacodynamics, Pharmacokinetics, and Safety of Obicetrapib in Patients with Early Alzheimer’s Disease (Hetero/Homozygote APOE4 Carr...
    Medical condition: Alzheimer's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-000662-23 Sponsor Protocol Number: BO21015 Start Date*: 2008-10-28
    Sponsor Name:F. Hoffmann La-Roche Ltd
    Full Title: A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, w...
    Medical condition: Locally advanced, metastatic or recurrent Non-small Cell Lung Cancer
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061873 Non-small cell lung cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) ES (Completed) HU (Completed) BE (Completed) DE (Completed) DK (Completed) CZ (Completed) IT (Completed) FR (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-004512-11 Sponsor Protocol Number: FJD-VITDAMI-14-01 Start Date*: 2015-08-06
    Sponsor Name:INSTITUTO DE INVESTIGACION SANITARIA FJD
    Full Title: Multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of vitamin D on ventricular remodeling in patients with acute myocardial infarction: Test VITDAMI (Vitamin D i...
    Medical condition: Acute myocardial infarction with ST segment elevation anterior
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004656-30 Sponsor Protocol Number: ICOR-2016-05 Start Date*: 2018-10-19
    Sponsor Name:Instituto de Investigación en Ciencias de la Salud Germans Trias i Pujol (IGTP)
    Full Title: EVOlocumab in stable Heart Failure with reduced ejection fraction of ischemic etiology: EVO-HF Pilot
    Medical condition: stable coronary artery disease and stable heart failure with reduced ejection fraction
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10078289 Heart failure with reduced ejection fraction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2011-005683-21 Sponsor Protocol Number: ENM-EA-030 Start Date*: 2012-10-09
    Sponsor Name:Medizinische Universität Graz
    Full Title: Effects of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
    Medical condition: Primary hyperparathyroidism
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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