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Clinical trials for Total Knee Replacement

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44343   clinical trials with a EudraCT protocol, of which   7372   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    107 result(s) found for: Total Knee Replacement. Displaying page 4 of 6.
    « Previous 1  2  3  4  5  6  Next»
    EudraCT Number: 2009-011233-27 Sponsor Protocol Number: 09/WNo02/7 Start Date*: 2009-09-10
    Sponsor Name:North Wales NHS Trust
    Full Title: Comparison of efficacy of concentration with volume of local anaesthetics in femoral-sciatic blocks for total knee replacement
    Medical condition: No medical condition or disease under investigation.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002182 Analgesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-001998-10 Sponsor Protocol Number: 1160.24 Start Date*: 2005-08-01
    Sponsor Name:Boehringer Ingelheim Ltd.
    Full Title: A phase III, randomized, parallel-group, double-blind, active controlled study to investigate the efficacy and safety of two different dose regimens (75mg day 1 followed by 150 mg day 2-completion,...
    Medical condition: Prevention of venous thromboembolism in patients with primary elective total knee replacement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-001432-62 Sponsor Protocol Number: 2012-006-M Start Date*: 2012-08-28
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Local infiltration anesthesia in Total Knee Arthroplasty
    Medical condition: Local infiltration analgesia (LIA) a multimodal pain management strategy in total knee arthroplasty.This study will investigate the effect of LIA on postoperative pain, opiod consumption, length of...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000242-17 Sponsor Protocol Number: Protocol_PPB_TKA_14012021 Start Date*: 2021-03-12
    Sponsor Name:Region Hospital Silkeborg
    Full Title: The effect of the popliteal plexus block on postoperative opioid consumption, pain, muscle strength and mobilization after total knee arthroplasty - a randomized, controlled, blinded study
    Medical condition: Postoperative pain following a total knee arthroplasty surgery
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-004620-40 Sponsor Protocol Number: BAY 59-7939/11356 Start Date*: 2006-01-26
    Sponsor Name:Bayer HealthCare AS
    Full Title: RECORD 3 Study: REgulation of Coagulation in ORthopedic Surgery to Prevent DVT and PE; controlled, double-blind, randomized study of BAY 59-7939 in the prevention of VTE in subjects undergoing elec...
    Medical condition: Prevention of venous thromboembolism
    Disease: Version SOC Term Classification Code Term Level
    8.1 10012108 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed) SE (Completed) DE (Completed) DK (Completed) BE (Completed) ES (Completed) CZ (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-003256-29 Sponsor Protocol Number: MNX2008 Start Date*: 2009-06-17
    Sponsor Name:Charité – Universitätsmedizin Berlin
    Full Title: Effect of Methylnaltrexone on Postoperative Analgesic Demands
    Medical condition: Pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-003537-15 Sponsor Protocol Number: TXA2018 Start Date*: 2019-02-18
    Sponsor Name:Medical University Vienna
    Full Title: Different dosing of Tranexamic Acid in patients undergoing elective total hip or knee arthroplasty. A randomized, controlled, double-blinded clinical trial.
    Medical condition: Blood loss in patients undergoing elective total hip or knee arthroplasty.
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10053220 Hip injury LLT
    20.1 100000004863 10049032 Knee injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-003122-88 Sponsor Protocol Number: SELK2-00005 Start Date*: 2019-01-21
    Sponsor Name:Tetherex Pharmaceuticals Corporation
    Full Title: A Phase 2, Randomized, Active Comparator-Controlled, Open-Label, Adaptive Design Study to Assess the Safety and Efficacy of Intravenously-Administered SelK2 in Patients Undergoing Total Knee Arthro...
    Medical condition: Venous thromboembolism occurring in patients undergoing total knee replacement arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10051055 Deep vein thrombosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: LV (Completed) BG (Completed) LT (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2022-000663-45 Sponsor Protocol Number: PREVENT-iT-2021.07 Start Date*: 2023-02-01
    Sponsor Name:Hamilton Health Sciences Corporation
    Full Title: Prospective Randomized Evaluation of Emerging Novel Treatments for Infection prophylaxis in Total Joint Replacement (PREVENT-iT): A Pilot Study
    Medical condition: Persistent Draining Wound and Periprosthetic Joint Infection prevention in patients undergoing total joint replacement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003721-22 Sponsor Protocol Number: A4091058 Start Date*: 2016-01-14
    Sponsor Name:Pfizer Inc, 235 East 42nd Street, New York, NY 10017
    Full Title: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROLLED, MULTICENTER STUDY OF THE LONG-TERM SAFETY AND EFFICACY OF SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP ...
    Medical condition: Osteoarthritis of the hip or knee
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) SK (Completed) LT (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2019-001725-27 Sponsor Protocol Number: KKSH152 Start Date*: 2019-10-24
    Sponsor Name:Martin-Luther-Universität Halle-Wittenberg
    Full Title: A randomized, open, three-arm comparative study of modern methods of postoperative pain therapy in patients with knee endoprostheses.
    Medical condition: Postoperative pain therapy after implantation of a knee endoprosthesis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10036276 Postoperative analgesia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-001754-92 Sponsor Protocol Number: AAE581C2201 Start Date*: 2005-02-14
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A phase II, 12-month, double-blind, placebo-controlled, dose-finding, multicenter study to evaluate the safety, tolerability, and disease modifying efficacy of daily oral AAE581 (10, 25 and 50 mg t...
    Medical condition: Osteoarthritis (OA) is a disease with a complex pathophysiology leading to the degeneration of articular cartilage and bone. It is characterized by pain, biochemical and enzymatic changes, cartilag...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2004-000610-39 Sponsor Protocol Number: ITI101711 Start Date*: 2005-12-15
    Sponsor Name:GlaxoSmithKline Research and Development Ltd.
    Full Title: A Dose Ranging Trial for the Evaluation of the Safety, Tolerability and Efficacy of Odiparcil in the Prevention of Venous Thromboembolism following Total Knee Replacement Surgery.
    Medical condition: Venous Thromboembolism
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) LT (Completed) LV (Completed)
    Trial results: View results
    EudraCT Number: 2010-020919-37 Sponsor Protocol Number: KA07052010 Start Date*: 2010-11-19
    Sponsor Name:University Hospitals Leuven
    Full Title:
    Medical condition: Post operative pain after total knee replacement
    Disease: Version SOC Term Classification Code Term Level
    12.1 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-003395-23 Sponsor Protocol Number: HK_VL_08_2014 Start Date*: 2015-01-20
    Sponsor Name:Section for Surgical Pathophysiology, Rigshospitalet
    Full Title: Effect of preoperative intravenous highdose methylprednisolone on quadriceps muscle function, endothelial function, complement activation and glucose homeostasis in patients scheduled for total kne...
    Medical condition: Knee joint arthrosis
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10003416 Arthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005642-22 Sponsor Protocol Number: SM3-PJ-14 Start Date*: 2015-03-06
    Sponsor Name:Pia Jæger
    Full Title: Adductor canal block with continuous infusion versus intermittent boluses and morphine consumption: A randomized, triple-masked, controlled study
    Medical condition: Primary total knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-002402-60 Sponsor Protocol Number: BAY 59-7939/11355 Start Date*: 2007-03-27
    Sponsor Name:Bayer Pharmaceutical
    Full Title: RECORD 4 Study: REgulation of Coagulation in ORthopedic Surgery to Prevent DVT and PE; a controlled, double-blind, randomized study of BAY 59-7939 in the prevention of VTE in subjects undergoing el...
    Medical condition: Prevention of venous thromboembolism
    Disease: Version SOC Term Classification Code Term Level
    8.1 10012108 Deep venous thrombosis prophylaxis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) SE (Completed) DK (Completed) LT (Completed)
    Trial results: View results
    EudraCT Number: 2014-002744-40 Sponsor Protocol Number: HK_EA_02_2014 Start Date*: 2014-09-23
    Sponsor Name:Section For Surgical Pathophysiology, Rigshospitalet
    Full Title: Preoperative intraarticular injection of methylprednisolone, in patients scheduled for total knee-arthroplasty
    Medical condition: Knee joint arthrosis with hyperalgesia and severe movement related pain
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004859 10003416 Arthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-006202-26 Sponsor Protocol Number: DRI6243 Start Date*: 2006-05-04
    Sponsor Name:Sanofi-Aventis Recherche et Développement
    Full Title: A Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel group, Dose Response Study of subcutaneous AVE5026 with an Enoxaparin Calibrator Arm in the Prevention of Venous Thromboembolism in P...
    Medical condition: Patients undergoing elective total knee replacement surgery (risk of venous thromboembolic event)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10049909 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) FI (Completed) PT (Completed) DK (Completed) NO (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2005-005494-29 Sponsor Protocol Number: 1603 Start Date*: Information not available in EudraCT
    Sponsor Name:Ullevål University Hospital
    Full Title: Rifampin combination therapy versus monotherapy in early staphylococcal infections after total hip and knee arthroplasty
    Medical condition: Joint prosthesis infection after total hip and knee arthroplasty.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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