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Clinical trials for Physiological effect

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    409 result(s) found for: Physiological effect. Displaying page 5 of 21.
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    EudraCT Number: 2019-002032-84 Sponsor Protocol Number: ELYS-CS01 Start Date*: 2019-10-31
    Sponsor Name:Disphar International B.V
    Full Title: Evaluating the Use of a Progesterone Receptor Modulator for Cervical Ripening at Full Term Pregnancy – a Randomized, Double-blind , placebo controlled Study (LUCYNA)
    Medical condition: Full-term pregnancy women at week 40 + 5 of gestation with intact membranes, the first delivery, singleton physiological pregnancy
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004868 10036880 Prolonged pregnancy, with delivery LLT
    Population Age: Adults Gender: Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-002223-32 Sponsor Protocol Number: E2007-0507 Start Date*: Information not available in EudraCT
    Sponsor Name:Charité Universitaetsmedizin
    Full Title: A multicentre, double-blind, randomised placebo-controlled trial of sodium bicarbonate to prevent acute kidney injury in patients undergoing cardiopulmonary bypass surgery.
    Medical condition: Cardiac surgical patients in whom the use of cardiopulmonary bypass is planned and having at least one ore more of the following risk factors for post-operative acute kidney injury • Age ≥ 70 years...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-001761-11 Sponsor Protocol Number: 300488 Start Date*: 2015-08-31
    Sponsor Name:The Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital
    Full Title: Lymphatic dysfunction as a cause of calcium channel blocker oedema in post-menopausal women
    Medical condition: Calcium channel antagonist induced peripheral edema in post-menopausal women. We hypothesize that this condition is partly due to impaired lymphatic function in these patients.
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004867 10067033 Drug side effect LLT
    18.0 100000004867 10034570 Peripheral edema LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-002116-10 Sponsor Protocol Number: i3.1_IBS+SIBO Start Date*: 2019-09-27
    Sponsor Name:AB-Biotics S.A.
    Full Title: Interventional post-marketing study to evaluate i3.1 efficacy on SIBO (Small Intestinal Bacterial Overgrowth)reduction in IBS (Irritable bowel syndrom) patients
    Medical condition: Irritable Bowel Syndrome (IBS) + Small Intestinal Bacterial Overgrowth (SIBO)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-000438-38 Sponsor Protocol Number: CRO 682 Start Date*: 2007-04-12
    Sponsor Name:Imperial College London
    Full Title: Efficacy of Lopinavir in Pregnancy: Pharmacokinetic and Virological Studies with Kaletra melt extruded tablet formulation
    Medical condition: HIV infection
    Disease: Version SOC Term Classification Code Term Level
    9.1 10008922 Chronic infection with HIV LLT
    Population Age: Adolescents, Under 18, Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005497-28 Sponsor Protocol Number: PedMic Start Date*: 2013-09-27
    Sponsor Name:Erasmus MC - Sophia
    Full Title: Pediatric Microdosing: elucidating age-related changes in oral absorption
    Medical condition: Age-related changes in intestinal drug metabolism in children
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-002094-38 Sponsor Protocol Number: 0584 Start Date*: 2016-12-29
    Sponsor Name:University of Leicester
    Full Title: The Effect of an SGLT2 inhibitor on Glucose Flux, Lipolysis and Ketogenesis following insulin withdrawal in people with absolute or relative endogenous insulin deficiency
    Medical condition: Type 1 and Type 3c diabetes
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2017-005110-58 Sponsor Protocol Number: 64024 Start Date*: 2018-06-14
    Sponsor Name:Medical Centre Leeuwarden
    Full Title: Efficacy of a predefined vitamin D dosing regimen in vitamin D-insufficient multiple myeloma patients.
    Medical condition: Hypovitaminosis D
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-003623-23 Sponsor Protocol Number: can.clo.ris.fMRI Start Date*: 2008-09-17
    Sponsor Name:Academisch medisch centrum, department of psychiatry
    Full Title: Effect of different antipsychotic medication on craving related brain activity in patients with schizophrenia and cannabis abuse or dependence: a randomized controlled study comparing clozapine and...
    Medical condition: A randomized controlled trial comparing the effect of clozapine and risperidone on cannabis craving in cannabis abusing or dependent patients with schizophrenia. Specific cognitive tasks will be us...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000573-72 Sponsor Protocol Number: ATOS-010 Start Date*: 2018-04-21
    Sponsor Name:Atossa Genetics Inc
    Full Title: Karma CREME-1: A double-blind, placebo-controlled, three-armed, pilot study of the effects, safety and tolerability of topical endoxifen in women within the Karma Cohort
    Medical condition: The mammographic density reduction in healthy women.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2015-001196-46 Sponsor Protocol Number: OPHT-240215 Start Date*: 2015-05-15
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of simvastatin withdrawal on ocular endothelial function
    Medical condition: endothelial dysfunction in cardiovascular diseases
    Disease: Version SOC Term Classification Code Term Level
    19.1 10047065 - Vascular disorders 10048554 Endothelial dysfunction PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2011-006129-17 Sponsor Protocol Number: 178S11PF Start Date*: 2012-05-18
    Sponsor Name:PASCOE Pharmazeutische Präparate GmbH
    Full Title: A randomized, double blind, placebo-controlled pilot study on the efficacy of Passiflora incarnata L. in an acute stressful situation
    Medical condition: Since only healthy volunteers will be included in this study, there is no medical condition to be examined. The indication for PASCOFLAIR® is nervous restlessness, a subclinical state of stress-sen...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-000189-12 Sponsor Protocol Number: ABR43234 Start Date*: 2013-03-14
    Sponsor Name:University Medical Centre Nijmegen
    Full Title: Effects of the selective mineralocorticoid receptor antagonist eplerenone on extracellular formation of adenosine
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-001314-25 Sponsor Protocol Number: KIANANDR140701 Start Date*: 2015-03-10
    Sponsor Name:Karolinska Institutet
    Full Title: The effect of on demand versus continuous use of proton pump inhibitors on reflux symptoms, quality of life and self-rated health in patients with gastro-oesophageal reflux disease
    Medical condition: Gastrooesophageal reflux disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: View results
    EudraCT Number: 2022-001603-40 Sponsor Protocol Number: P22-XXX Start Date*: 2022-07-18
    Sponsor Name:Leiden University Medical Center
    Full Title: Combined effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on breathing: an exploratory study in healthy volunteers the POLO study
    Medical condition: Healthy Volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002282-30 Sponsor Protocol Number: 2014-2 Start Date*: 2014-07-30
    Sponsor Name:County council of Ostergotland
    Full Title: Effects of oxygen treatment on mechanisms involved in ischemia-reperfusion injury: A pilot study in healthy volunteers.
    Medical condition: Study performed in healthy male vonlunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-001683-22 Sponsor Protocol Number: 1/2011AITT Start Date*: 2011-06-10
    Sponsor Name:University of Debrecen, Medical and Health Science Center, Department of Anaesthesiology and Intensive Therapy
    Full Title: Reversal of residual rocuronium neuromuscular block using sugammadex: a prospective, dobule-blind, randomized, controlled, dose-finding study
    Medical condition: The effect of sugammadex dose on residual neuromuscular blockade will be investigated, therefore patients suffering from various conditions undergoing surgery in general anaesthesia with muscle rel...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004666-34 Sponsor Protocol Number: AITT2014/1 Start Date*: 2014-03-17
    Sponsor Name:University of Debrecen, Medical and Health Science Center, Department of Anaesthesiology and Intensive Therapy
    Full Title: Reversal of vecuronium induced residual neuromuscular block using sugammadex: a prospective, dobule-blind, randomized, controlled, dosefinding study
    Medical condition: The effect of sugammadex dose on residual neuromuscular blockade will be investigated, therefore patients suffering from various conditions undergoing surgery in general anaesthesia with muscle rel...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000083-29 Sponsor Protocol Number: P21.xxx Start Date*: 2021-07-13
    Sponsor Name:Leiden University Medical Center
    Full Title: Influence of ∆9-tetrahydrocannabinol (THC) on oxycodone induced ventilatory depression in healthy volunteers
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004189-33 Sponsor Protocol Number: REK322442 Start Date*: 2013-11-28
    Sponsor Name:Haukeland University Hospital
    Full Title: ULTRADIAN SUBCUTANEOUS HYDROCORTISONE (USHI) INFUSION IN ADDISON’S DISEASE
    Medical condition: Addison`s disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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