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Clinical trials

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    44,346 result(s) found. Displaying page 519 of 2,218.
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    EudraCT Number: 2008-006749-18 Sponsor Protocol Number: HE06-001-C P4 Start Date*: 2009-06-26
    Sponsor Name:Fresenius Kabi Deutschland GmbH
    Full Title: Efficacy and safety of 6 % hydroxyethyl starch 130/0.4 (Voluven®) vs. 5% HSA in volume replacement therapy during elective open-heart surgery in paediatric patients
    Medical condition: Volume replacement therapy during elective open-heart surgery in paediatric patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10048935 Open heart surgery LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: AT (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2011-005497-28 Sponsor Protocol Number: PedMic Start Date*: 2013-09-27
    Sponsor Name:Erasmus MC - Sophia
    Full Title: Pediatric Microdosing: elucidating age-related changes in oral absorption
    Medical condition: Age-related changes in intestinal drug metabolism in children
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-005514-10 Sponsor Protocol Number: 0822-018 Start Date*: 2012-03-14
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A 2nd Open-Label Extension for 5 Years to: The Placebo-Controlled 1st Extension to a Randomized, Placebo-Controlled Clinical Trial to Assess the Safety and Efficacy of Odanacatib (MK-0822) to Reduc...
    Medical condition: Postmenopausal Osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10031285 Osteoporosis postmenopausal PT
    Population Age: Elderly Gender: Female
    Trial protocol: LT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004391-11 Sponsor Protocol Number: RCC-DC-2011 Start Date*: 2012-02-08
    Sponsor Name:Masaryk University
    Full Title: Treatment of metastatic renal cell carcinoma using interleukin-12 secreting dendritic cells. Phase I/II clinical trial.
    Medical condition: Metatastic renal cell carcinoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-001642-14 Sponsor Protocol Number: n/a Start Date*: 2011-07-11
    Sponsor Name:University of Surrey
    Full Title: The effects of subcutaneous insulin detemir on glucose flux, pharmacokinetics and brain function in type one diabetes
    Medical condition: Type 1 diabetes mellitus
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-004755-39 Sponsor Protocol Number: ML25710 Start Date*: 2012-08-17
    Sponsor Name:Genentech, Inc.
    Full Title: A randomized phase II study of Bevacizumab/mFOLFOX6 vs. Bevacizumab/FOLFIRI with biomarker stratification in patients with previously untreated metastatic colorectal cancer
    Medical condition: Metastatic colorectal cancer
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004864 10052362 Metastatic colorectal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) EE (Completed) PT (Completed)
    Trial results: View results
    EudraCT Number: 2009-015296-26 Sponsor Protocol Number: SCLC Start Date*: 2009-12-09
    Sponsor Name:AZIENDA USL 6 LIVORNO ZONA LIVORNESE
    Full Title: MULTICENTRIC PROSPECTIVE DOSE-FINDING AND PHASE II STUDY WITH ORAL TOPOTECAN IN ADVANCED SMALL-CELL LUNG CANCER (SCLC) PATIENTS RECURRENT AFTER A FIRST LINE THERAPY
    Medical condition: patients with ADVANCED SMALL-CELL LUNG CANCER (SCLC)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10041059 HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-015383-33 Sponsor Protocol Number: Eto-Dic-01 Start Date*: 2010-08-30
    Sponsor Name:Freistaat Bayern, vertreten durch die Universität Regensburg
    Full Title: Die perioperative Anwendung von Etoricoxib verglichen mit Diclofenac bei Patienten nach Implantation einer Hüftgelenkstotalendoprothese, prospektive, doppelt blinde Phase IIIb Studie
    Medical condition: In this clinical trial we will investigate patients who suffer from primary or secondary coxarthrosis where an implantation of a total hip joint endoprosthesis is indicated. It will be analyzed whe...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10048793 Coxarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000612-26 Sponsor Protocol Number: FINTOURPARK Start Date*: 2011-09-19
    Sponsor Name:AZIENDA OSPEDALIERO UNIVERSITARIA DI CAGLIARI
    Full Title: Open-label study on the use of Finasteride in prolonged treatment (4 years) of tics in Tourette's disease and Parkinson's disease in the pounding
    Medical condition: Syndrome Gilles de la Tourette's disease Parkinosn Pounding
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10013113 Disease Parkinson's LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000626-29 Sponsor Protocol Number: KS001 Start Date*: 2011-12-13
    Sponsor Name:QUEEN MARY UNIVERSITY OF LONDON
    Full Title: Keloid Scars: A randomised clinical and laboratory based study on the treatment and differentiation factors of the local disease
    Medical condition: Keloid scarring
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-000631-92 Sponsor Protocol Number: CQGE031A2208 Start Date*: 2011-12-07
    Sponsor Name:Novartis Pharma AG
    Full Title: A phase II, randomized, double-blind, placebo controlled, parallel design, dose ranging, multi-center trial of four levels of exposure of QGE031 s.c. for 16 weeks in subjects aged 18 years and olde...
    Medical condition: Peanut allergy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021428 - Immune system disorders 10034202 Peanut allergy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) GB (Prematurely Ended) GR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004201-25 Sponsor Protocol Number: 1B Start Date*: 2011-11-30
    Sponsor Name:Erasmus MC
    Full Title: The BOKITO-1B Study: Tenofovir DF Bone and Kidney Toxicity. Pharmacology in HBV monoinfected patients.
    Medical condition: Chronic hepatitis B
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004217-17 Sponsor Protocol Number: CICL670AUS32 Start Date*: 2011-12-09
    Sponsor Name:Novartis Pharmaceuticals Corporation
    Full Title: A single-arm, open-label study of the Palatability and Tolerability of Exjade Taken with Meals, with Different Liquids or Crushed and Added to Food
    Medical condition: transfusional hemosiderosis
    Disease: Version SOC Term Classification Code Term Level
    14.0 10027433 - Metabolism and nutrition disorders 10065974 Chronic iron overload LLT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2006-006537-40 Sponsor Protocol Number: VEG108838 Start Date*: 2008-01-22
    Sponsor Name:GlaxoSmithkline Research & Development Limited
    Full Title: A Randomized, Multicenter, Phase III Study Comparing the Combination of Pazopanib and Lapatinib versus Lapatinib Monotherapy in Patients with ErbB2 over-expressing Inflammatory Breast Cancer
    Medical condition: Relapsed or refractory inflammatory breast cancer with ErbB2 tumours.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021974 Inflammatory breast cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed) BE (Completed) DE (Prematurely Ended) GB (Completed) FR (Completed) ES (Completed) IT (Completed) CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004718-40 Sponsor Protocol Number: MELCOM-1 Start Date*: 2011-07-18
    Sponsor Name:AISAR ASSOCIAZIONE ITALIANA PER LO STUDIO DEGLI ANTIMICROBICI E DELLE RESISTENZE
    Full Title: Activities of Metronidazole + Clotrimazole in the treatment and prophylaxis of recurrent vaginal infections recurrent Candida albicans and Candida albicans spp do not.
    Medical condition: women with vaginal infections by Candida albicans and non-albicans Candida spp relapsing recurrent (≥ 4 events / year) in the acute phase of the disease.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10021881 Infections and infestations SOC
    Population Age: Adults Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000233-37 Sponsor Protocol Number: IGFIMD Start Date*: 2011-04-05
    Sponsor Name:Stockholm Läns Landsting, Karolinska University Hospital
    Full Title: Insulin-like Growth Factor (IGF-I) induced muscle glucose uptake and interstitial IGF-1 concentrations. Placebo controlled, crossover study of the effect of sc rhIGF-I(Increlex) administration on g...
    Medical condition: Type 1 Diabetes Mellitus
    Disease: Version SOC Term Classification Code Term Level
    12.1 10012608 Diabetes mellitus insulin-dependent LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000257-23 Sponsor Protocol Number: CTMK13 Start Date*: 2011-06-14
    Sponsor Name:Thornton & Ross Ltd
    Full Title: A randomised, controlled, assessor-blind, clinical trial to demonstrate superiority of Hedrin® Once liquid gel compared with Lyclear 1% permethrin crème rinse in the treatment of head lice
    Medical condition: Head louse infestation (pediculosis capitis)
    Disease: Version SOC Term Classification Code Term Level
    13.1 10021881 - Infections and infestations 10034214 Pediculus capitis (head louse) LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023208-29 Sponsor Protocol Number: OXT-003 Start Date*: 2011-08-02
    Sponsor Name:Rheinische Friedrich-Wilhelms-University of Bonn
    Full Title: Effects of Oxytocin on opioide withdrawal symptoms
    Medical condition: Individuals with opioid dependence who are voluntary inpatients from detoxification unit are investigated. The opioid withdrawal symptome are observed.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003470-88 Sponsor Protocol Number: 11-195 Start Date*: 2012-07-30
    Sponsor Name:University Medical Center Utrecht, The Netherlands
    Full Title: Phenylephrine versus EPhedrine on cerebral Perfusion during carotid EndarteRectomy: PEPPER study
    Medical condition: Hypotension during carotid endarterectomy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10062300 Procedural hypotension PT
    14.1 10042613 - Surgical and medical procedures 10007692 Carotid endarterectomy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003486-15 Sponsor Protocol Number: SP0934 Start Date*: 2012-06-13
    Sponsor Name:UCB BIOSCIENCES GmbH
    Full Title: A multi-center, randomized, double-blind, placebo-controlled, parallel group, polysomnography study to investigate safety and efficacy of the rotigotine transdermal patch in subjects with Restless ...
    Medical condition: Restless Legs Syndrome in patients with End Stage Renal Disease (ESRD)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10029205 Nervous system disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) FI (Completed) AT (Completed) IT (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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