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Clinical trials for Side effects

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44380   clinical trials with a EudraCT protocol, of which   7392   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    2,083 result(s) found for: Side effects. Displaying page 6 of 105.
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    EudraCT Number: 2012-002618-38 Sponsor Protocol Number: AnesBar01 Start Date*: 2013-10-15
    Sponsor Name:
    Full Title: Does preperitoneal local anesthesia in laparoscopic gastric bypass surgery reduce postoperative pain and opioid consumption?
    Medical condition: Postoperative pain
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004863 10054711 Postoperative pain LLT
    16.0 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2022-001582-12 Sponsor Protocol Number: 4 Start Date*: 2023-03-01
    Sponsor Name:Consorcio Centro de Investigacion Biomedica en Red (CIBER)
    Full Title: Open, multicenter, randomized clinical trial to evaluate the efficacy and safety of aripiprazole vs paliperidone / risperidone using multi-omics data in patients with a first psychotic episode.
    Medical condition: First episode SZ-spectrum individuals
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-001284-20 Sponsor Protocol Number: BIOGIO Start Date*: 2017-07-05
    Sponsor Name:Erasmus MC Cancer Institute
    Full Title: The effects of the proton pump inhibitor esomeprazole on the bioavailability of afatinib (Giotrif®) in patients with non-small cell lung cancer (NSCLC) 'the BIO-GIO study'
    Medical condition: Non small cell lung cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005784-17 Sponsor Protocol Number: REGORA Start Date*: 2016-05-19
    Sponsor Name:Erasmus MC cancer institute
    Full Title: The effects of the proton pump inhibitor esomeprazole on the bioavailability of regorafenib in patients with a metastatic colorectal cancer (mCRC) or gastrointestinal stromal tumour (GIST).
    Medical condition: GIST and mCRC patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002826-58 Sponsor Protocol Number: 1 Start Date*: 2020-02-05
    Sponsor Name:Rijnstate Hospital, Arnhem
    Full Title: The effects of enoximone in acute exacerbation COPD: a pilot study
    Medical condition: Acute exacerbation of COPD
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003882-17 Sponsor Protocol Number: MKM Start Date*: 2013-05-06
    Sponsor Name:Charité Universitaetsmedizin Berlin
    Full Title: Effects of modafinil, caffeine and methylphenidate on functional brain activity and cognitive performance in healthy subjects: a randomized, placebo-controlled, double-blind fMRI study.
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2017-001915-35 Sponsor Protocol Number: 08052017 Start Date*: 2017-09-15
    Sponsor Name:Medical University of Graz
    Full Title: GLUCOCORTICOID HIGH-DOSE VS. REPLACEMENT IN IMMUNE CHECKPOINT INHIBITOR ASSOCIATED HYPOPHYSITIS: AN OPEN, RANDOMIZED PILOT STUDY
    Medical condition: Immune regulatory antibodies (e.g. ipilimumab, pembrolizumab and nivolumab) inhibiting immunological checkpoints are increasingly used to treat various oncological entities. Potential side effects ...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-002622-75 Sponsor Protocol Number: 2013 Start Date*: 2013-05-21
    Sponsor Name:Vibeke Hjortdal
    Full Title: Lymphatic dysfunction as a cause of calcium channel blocker oedema
    Medical condition: Fluid accumulation in the leg associated with calcium channel blocker therapy.
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004867 10067033 Drug side effect LLT
    16.0 100000004867 10034570 Peripheral edema LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-001541-18 Sponsor Protocol Number: T3RIS22007 Start Date*: 2007-10-08
    Sponsor Name:Institute of Psychophysiology and Rehabilitation (IRP) of the Kaunas University of Medicine
    Full Title: Triiodothyronine as an adjunct in treatment of acute schizophrenia
    Medical condition: Acute Schizoprenia episode
    Disease: Version SOC Term Classification Code Term Level
    9.1 10001065 Acute schizophrenia episode LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: LT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000848-95 Sponsor Protocol Number: 020119 Start Date*: 2019-07-29
    Sponsor Name:Dansk Hovedpine Center, Neurologisk Klinik, Rigshospitalet - Glostrup
    Full Title: A Placebo-Controlled, Double-Blind, Randomized, Proof-of-Concept Study to Evaluate the Efficacy and Tolerability of Erenumab in Patients with Trigeminal Neuralgia
    Medical condition: Trigeminal neuralgia
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10044652 Trigeminal neuralgia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000779-33 Sponsor Protocol Number: UMCN-AKF-18.01 Start Date*: 2018-11-05
    Sponsor Name:Radboud University Medical Center
    Full Title: Effect of a reduced dose on cognitive side effects of enzalutamide in frail (m)CRPC patients
    Medical condition: (Metastatic) Castration Resistant Prostate Cancer (mCRPC)
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10036909 Prostate cancer metastatic PT
    21.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10076506 Castration-resistant prostate cancer LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2020-004872-17 Sponsor Protocol Number: IC2020-04 Start Date*: 2021-03-18
    Sponsor Name:INSTITUT CURIE
    Full Title: A Double-blind Randomized non-inferiority Trial of erector spinae block (ESP) versus paravertebral block (PVB) before Breast Cancer Surgery: Effects on acute Postoperative Pain
    Medical condition: Nervous Block erector spinae plane (ESP) or paravertebral block (PVB) preoperatively in women with breast adenocarcinoma without metastasis or breast in situ adenocarcinoma to by treated either by...
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004867 10003034 Application site anesthesia LLT
    20.0 100000004864 10006290 Breast and nipple neoplasms malignant HLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001951-36 Sponsor Protocol Number: HTG-Oxy1 Start Date*: 2006-05-15
    Sponsor Name:Medical University of Vienna
    Full Title: Perioperative Analgesie in der Gefäßchirurgie
    Medical condition: peripheral vascular disease, inclusion criteria: elective vascular surgery, age 30 to100years; male and female; exclusion Criteria: amaurosis, insufficient language skills, permanent opioid medicat...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-001539-29 Sponsor Protocol Number: alsbjerg1 Start Date*: 2019-10-11
    Sponsor Name:The Fertility Clinic, Skive Regional Hospital
    Full Title: Optimizing serum progesterone level during luteal phase in hormone replacement therapy frozen embryo transfer (HRT-FET) cycle – interventional and observational trial
    Medical condition: Infertility
    Disease: Version SOC Term Classification Code Term Level
    21.0 10038604 - Reproductive system and breast disorders 10021926 Infertility PT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2010-023538-22 Sponsor Protocol Number: LY107 Start Date*: 2011-08-30
    Sponsor Name:Lipid Pharmaceuticals
    Full Title: Lýsi sem hægðalyf fyrir börn
    Medical condition: The primary objective of this trial is to investigate the laxative effect of Lysisstílar (Free Fatty Acids suppositories) as compared to Klyx. Participants are children aged 1 year old to 17 year...
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IS (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-002450-30 Sponsor Protocol Number: AcadMed CTU03/05 Start Date*: 2006-07-12
    Sponsor Name:Hull and East Yorkshire Hospitals Trust
    Full Title: An Open label Study to Compare Systemic Side Effects of High Dose Fluticasone/Salmeterol with that of High Dose Ciclesonide /Salmeterol in Symptomatic Asthmatics
    Medical condition: Chronic asthma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-000076-33 Sponsor Protocol Number: UMCNONCO201007 Start Date*: 2011-11-15
    Sponsor Name:University Medical Centre Nijmegen
    Full Title: Efficacy and Cost Efficacy of Prophylactic treatment with Antibiotics during concomitant chemoradiotherapy in patients with locally advanced head and neck cancer to prevent Aspiration Pneumonia.
    Medical condition: Patients with LAHNC which will be treated with chemoradiotherapy, as primary treatment or as postoperative treatment
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002435-18 Sponsor Protocol Number: Diclometh-2015 Start Date*: 2015-07-27
    Sponsor Name:Aalborg University Hospital
    Full Title: An Evidence Based, Translational, Cross-Over, Randomized, Double-Blind, Placebo Controlled Study to Evaluate Effectiveness of Topically applied Combination of Diclofenac and Methadone Gel (Diclome...
    Medical condition: Healthy volunteers
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004852 10054095 Neuropathic pain LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003929-30 Sponsor Protocol Number: 1 Start Date*: 2022-10-14
    Sponsor Name:Ligalli BV
    Full Title: INFLUENCE OF OXYBUTYNIN - MEDRING LIGALLI ON OVERACTIVE BLADDER SYMPTOMS IN WOMEN
    Medical condition: urinary urge incontinence
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2023-000172-36 Sponsor Protocol Number: CHUB-Methadone Start Date*: 2023-02-28
    Sponsor Name:CHU Brugmann
    Full Title: Intraoperative methadone for the prevention of postoperative pain: a randomized, double-blind clinical study in orthopedic surgery.
    Medical condition: Orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    23.1 10042613 - Surgical and medical procedures 10051079 Orthopedic procedure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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