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Clinical trials for Amputation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44300   clinical trials with a EudraCT protocol, of which   7354   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    156 result(s) found for: Amputation. Displaying page 1 of 8.
    1  2  3  4  5  6  7  8  Next»
    EudraCT Number: 2006-005667-26 Sponsor Protocol Number: 130256 Start Date*: 2007-07-11
    Sponsor Name:Ninewells Hospital
    Full Title: A randomised, placebo controlled trial of levobupivacaine or the combination of levobupivacaine and clonidine when administered as a sciatic perineural infusion for the prevention of phantom limb p...
    Medical condition: Pain after amputation
    Disease: Version SOC Term Classification Code Term Level
    8.1 10004227 Below knee amputation LLT
    9.1 10000243 Above knee amputation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-000875-33 Sponsor Protocol Number: PLATA Start Date*: 2013-08-27
    Sponsor Name:Academic Medical Center, University of Amsterdam
    Full Title: Prevention of Phantom Limb Pain After Transtibial Amputation (PLATA) - Randomized, double-blind, controlled, multi-center trial comparing Optimized intravenous pain control vs Optimized intravenous...
    Medical condition: Phantom limb pain following amputation of the lower leg due to critical limb ischemia.
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10004227 Below knee amputation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing) ES (Ongoing) AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003574-66 Sponsor Protocol Number: 34964 Start Date*: 2013-01-04
    Sponsor Name:Ortopædkirurgisk Forskning - Aarhus Universitetshospita
    Full Title: Osseointegrated transdermal femoral amputation prostheses - Denusomab Trial
    Medical condition: leg amputee
    Disease: Version SOC Term Classification Code Term Level
    16.0 10042613 - Surgical and medical procedures 10024124 Leg amputation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003637-41 Sponsor Protocol Number: BIOEU001.00 Start Date*: 2005-10-26
    Sponsor Name:Biopure Corporation
    Full Title: A Phase II, Multi-Center, Single-Blinded, Placebo-Controlled Study to Evaluate the Safety and Feasibility of Hemoglobin-Based Oxygen Carrier-201 (HBOC-201, hemoglobin-glutamer-250 (bovine)]) on Wo...
    Medical condition: Wound Healing in Patients with Peripheral Vascular Disease and Who are Undergoing a Lower Limb Amputation due to Critical Lower Limb Ischemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001701-97 Sponsor Protocol Number: version 2.0, dated 27/04/04 Start Date*: 2005-12-20
    Sponsor Name:Royal Berkshire and Battle Hospitals NHS Trust
    Full Title: Prospective randomised controlled trial of: MRSA Prophylaxis for lower limb amputation
    Medical condition: Post-operative MRSA infection following lower limb amputation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023426-20 Sponsor Protocol Number: AUGUST-2 Start Date*: 2011-04-08
    Sponsor Name:GWT-TUD GmbH
    Full Title: Low dose Urokinase therapy in patients with diabetic foot syndrome, critical limb ischemia as well as rest ischemia or missing of option revascularisation in comparison to the standard therapy - ra...
    Medical condition: Diabetic foot syndrome with critical limb ischemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-002655-24 Sponsor Protocol Number: SMR-1850/2PX-SP-02 Start Date*: 2008-09-30
    Sponsor Name:SantoSolve A/S
    Full Title: A randomised, double-blind, placebo (vehicle) controlled, parallel group study of the efficacy, safety and tolerability of topical 2PX (strontium chloride hexahydrate) in patients with chronic, mod...
    Medical condition: Post amputation patients (at least 6 months prior to visit 1) with chronic moderate-to-severe lower limb stump pain, defined as average stump pain on a daily basis (≥40 on a 100 mm pain VAS scale) ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023931 Late amputation stump complication LLT
    Population Age: Gender: Male, Female
    Trial protocol: DK (Completed) GB (Prematurely Ended) DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-003807-20 Sponsor Protocol Number: FinAPain-1 Start Date*: 2014-02-28
    Sponsor Name:HUS, Leikkaus- ja anestesiaosasto
    Full Title: Periferal local anesthetic infusion for postoperative pain after above knee amputation
    Medical condition: Pain after amputation above knee
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001587-30 Sponsor Protocol Number: GU11SU387 Start Date*: 2013-09-26
    Sponsor Name:NHS Greater Glasgow and Clyde
    Full Title: The role of pre-emptive analgesia with Qutenza (topical capsaicin 8%) in preventing neuropathic pain following lower limb amputation: a pilot randomised controlled study
    Medical condition: Chronic neuropathic pain following limb amputation
    Disease: Version SOC Term Classification Code Term Level
    16.0 10029205 - Nervous system disorders 10054095 Neuropathic pain LLT
    16.0 10029205 - Nervous system disorders 10029205 Nervous system disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-006277-24 Sponsor Protocol Number: EFC6145 Start Date*: 2008-04-10
    Sponsor Name:sanofi-aventis recherche et développement
    Full Title: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PARALLEL GROUP STUDY OF THE EFFICACY AND SAFETY OF 4 ADMINISTRATIONS OF XRP0038/NV1FGF 4mg AT 2–WEEK INTERVALS ON AMPUTATION OR ANY DEATH IN CRITICAL LI...
    Medical condition: Critical Limb Ischemia with skin lesions
    Disease: Version SOC Term Classification Code Term Level
    14.0 10047065 - Vascular disorders 10058069 Critical limb ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) HU (Completed) GB (Completed) CZ (Completed) GR (Completed) ES (Completed) AT (Completed) FI (Completed) SE (Completed) FR (Completed) EE (Completed) IT (Completed) DK (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2014-005569-58 Sponsor Protocol Number: BAY59-7939/17454 Start Date*: 2015-09-23
    Sponsor Name:Bayer AG
    Full Title: An international, multicenter, randomized, double-blind, placebo-controlled phase 3 trial investigating the efficacy and safety of Rivaroxaban to reduce the risk of major thrombotic vascular event...
    Medical condition: Peripheral artery disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10053375 Peripheral revascularization LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) AT (Completed) ES (Completed) HU (Completed) GB (Completed) FR (Completed) PT (Completed) SE (Completed) BE (Completed) BG (Completed) DK (Completed) DE (Completed) NL (Completed) PL (Completed) SK (Completed) LT (Completed) LV (Completed) RO (Completed) EE (Completed) FI (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2020-000449-15 Sponsor Protocol Number: DIONYSIUS Start Date*: 2020-12-11
    Sponsor Name:Amsterdam University Medical Centers, location AMC
    Full Title: Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently?
    Medical condition: Ischemic diabetic foot ulcers
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001397-15 Sponsor Protocol Number: BMMNC_CLI_001 Start Date*: 2016-06-15
    Sponsor Name:Institut klinické a experimentální medicíny
    Full Title: A prospective, randomized study to compare the effect on tissue oxygenation and clinical outcome of autologous bone marrow-derived mononuclear cell therapy with standard treatment in patients with ...
    Medical condition: Autologous cell therapy (ACT) is new technique for patients with critical limb ischemia and diabetic foot (DF). In our study, the effect of ACT and also the repetitive treatment will be compared wi...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10047065 - Vascular disorders 10034576 Peripheral ischaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005532-18 Sponsor Protocol Number: PLX-CLI-03 Start Date*: 2017-01-02
    Sponsor Name:Pluristem Ltd.
    Full Title: A Randomized, Double-Blind, Multicenter, Placebo-Controlled, Parallel-Group Phase III Study to Evaluate the Efficacy, Tolerability and Safety of Intramuscular Injections of PLX-PAD for the Treatmen...
    Medical condition: Critical Limb Ischemia (CLI)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004866 10058069 Critical limb ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) CZ (Prematurely Ended) AT (Completed) HU (Prematurely Ended) BG (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-001398-34 Sponsor Protocol Number: BMMNC_PTA_001 Start Date*: 2016-06-15
    Sponsor Name:Institut klinické a experimentální medicíny
    Full Title: A prospective, randomized study to assess the effect of autologous bone marrow-derived mononuclear cell therapy and its combination with percutaneous transluminal angioplasty (PTA) in comparison wi...
    Medical condition: In our study, the effect of autologous cell therapy (ACT) will be compared with repeated percutaneous transluminal angioplasty (re-PTA) in patients with diabetic foot and then will be compared the ...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10047065 - Vascular disorders 10062585 Peripheral arterial occlusive disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-001561-28 Sponsor Protocol Number: HES08 Start Date*: 2008-07-21
    Sponsor Name:Klinik für Anästhesiologie und Operative Intensivmedizin Klinikum Ludwigshafen
    Full Title: Influence of perioperative HES 130/04 adminstration on postoperative complications: A prospective randomized trial in patients undergoing colorectal surgery.
    Medical condition: Adult patients (>18 years) of both gender undergoing elective colorectal surgery (hemicolectomy left/right, sigmoid colectomy, rectal resection/amputation) without concomitant resection of liver me...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002942-12 Sponsor Protocol Number: P04737 Start Date*: 2007-10-22
    Sponsor Name:Schering-Plough Research Institute
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects With a History of Atherosclerotic Dis...
    Medical condition: Documented coronary artery disease, postischemic cerebrovascular disease or peripheral artery disease.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10043634 Thrombosis prophylaxis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) DK (Completed) NL (Completed) SE (Completed) PT (Completed) FI (Completed) CZ (Completed) GB (Completed) BE (Completed) IT (Completed) ES (Completed) AT (Completed) DE (Completed) PL (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2016-003544-37 Sponsor Protocol Number: ABUHB/01/0816/1 Start Date*: 2016-11-30
    Sponsor Name:Aneurin Bevan University Health Board
    Full Title: Perineural Local Anaesthetic Catheter aftEr Major lowEr limb amputatioN Trial (PLACEMENT)
    Medical condition: Analgesia for lower limb amputation for peripheral vascular disease (PVD)
    Disease: Version SOC Term Classification Code Term Level
    19.1 10042613 - Surgical and medical procedures 10042613 Surgical and medical procedures SOC
    19.1 10021881 - Infections and infestations 10021881 Infections and infestations SOC
    19.1 10018065 - General disorders and administration site conditions 10018065 General disorders and administration site conditions SOC
    19.1 10022117 - Injury, poisoning and procedural complications 10022117 Injury, poisoning and procedural complications SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-001780-37 Sponsor Protocol Number: * Start Date*: 2021-07-22
    Sponsor Name:Centre Hospitalier de Tourcoing
    Full Title: Prospective randomized controlled study of two antibiotic treatment times (3 versus 6 weeks) of diabetic foot osteomyelitis
    Medical condition: Patients de plus de 18 ans et de moins de 80 ans. Présentant une ostéite du pied diabétique.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10060803 Diabetic foot infection PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-005916-15 Sponsor Protocol Number: MC-UK.3/AVK Start Date*: 2008-04-25
    Sponsor Name:medac Gesellschaft für klinische Spezialpräparate mbH
    Full Title: Low dose Urokinase therapy by patients with diabetic foot syndrom and critical limb ischemia versus conventionel standard therapy. A randomised, open, controlled Phase III-study.
    Medical condition: Patients with angiopathic or angioaneuropathic diabetic foot syndrome and critical limb ischemia without the possibility of surgical or interventional revascularisation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012664 Diabetic foot ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
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