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Clinical trials for Antihypertensive drugs

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    104 result(s) found for: Antihypertensive drugs. Displaying page 1 of 6.
    1  2  3  4  5  6  Next»
    EudraCT Number: 2004-004933-32 Sponsor Protocol Number: km 55/2004 – LORISTAH/CZ Start Date*: 2005-03-04
    Sponsor Name:KRKA, d. d., Novo mesto
    Full Title: Efficacy and safety of Lorista and Lorista H in the treatment of mild to moderate arterial hypertension
    Medical condition: mild to moderate hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2020-003410-12 Sponsor Protocol Number: RG_19-169 Start Date*: 2020-12-16
    Sponsor Name:University of Birmingham
    Full Title: Pregnancy ANtihypertensive Drugs: which Agent is best?
    Medical condition: Hypertension in pregnancy (chronic hypertension, gestational hypertension or pre-eclampsia)
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-006981-40 Sponsor Protocol Number: hypertension2006-006981-40 Start Date*: 2007-05-03
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust jointly with University of Cambridge
    Full Title: Does the underlying haemodynamic abnormality determine response to antihypertensive therapy in patients with hypertension?
    Medical condition: Essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10004254 Benign essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) EE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001404-14 Sponsor Protocol Number: QGC001-3QG2 Start Date*: 2021-08-17
    Sponsor Name:Quantum Genomics
    Full Title: A Phase 3, Double-blind, Placebo-controlled and Open-label Efficacy and Long-term Safety Study of Firibastat (QGC001) Administered Orally, Once Daily, for Up to 48 Weeks in Patients with Difficult-...
    Medical condition: Treatment of patients with difficult-to-treat and/or treatment-resistant hypertension (HTN)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004866 10036695 Primary hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Prematurely Ended) HU (Prematurely Ended) ES (Ongoing) CZ (Prematurely Ended) IT (Completed) NL (Prematurely Ended) BE (Completed) BG (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-001898-25 Sponsor Protocol Number: DAR-311 Start Date*: 2006-09-21
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: DORADO - Fixed Doses of Darusentan as Compared to Placebo in Resistant Hypertension A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel Group Study to Evaluate the Effica...
    Medical condition: Resistant hypertension
    Disease: Version SOC Term Classification Code Term Level
    8.1 10038274 Refractory hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed) DE (Completed) GB (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2005-003182-16 Sponsor Protocol Number: A07329 Start Date*: 2005-08-26
    Sponsor Name:Addenbrooke's Hospital Trust
    Full Title: Blood Pressure Optimisation In Patients With Polycystic Kidney Disease And Hypertension By Rotation Through The Main Therapeutic Classes Of Antihypertensive Drugs.
    Medical condition: Polycystic kidney disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000577-13 Sponsor Protocol Number: kajakbe191086 Start Date*: 2015-09-09
    Sponsor Name:Oslo University Hospital
    Full Title: Therapeutic effects of BNP in uncontrolled hypertensive patients 1
    Medical condition: Uncontrolled hypertension (UHT, i.e. blood pressure ≥ 150/90, or ≥ 150/85 mm Hg in diabetic patients) despite treatment with at least two different classes of antihypertensive medications.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-006861-18 Sponsor Protocol Number: 20061212 Start Date*: 2007-03-26
    Sponsor Name:Department of Cardiology
    Full Title: Comparison between beta-adrenergic blockers and angiotensin II receptor antagonists for the treatment of late hypertension in patients with repaired aortic coarctation
    Medical condition: Aortic coarctation and late hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-000605-12 Sponsor Protocol Number: notapplicable1 Start Date*: 2014-06-13
    Sponsor Name:
    Full Title: Thiazide diuretics versus calcium channel blockers for the treatment of calcineurin inhibitor-induced hypertension in patients with psoriasis or eczema: a single-center randomized cross-over trial.
    Medical condition: Hypertension, induced by the use of a Calcineurin Inhibitor (CNI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-004704-35 Sponsor Protocol Number: NL39417.078.12 Start Date*: 2012-11-22
    Sponsor Name:
    Full Title: Thiazide diuretics versus calcium channel blockers for the treatment of tacrolimus-induced hypertension in dermatology patients: a single-center randomized cross-over trial.
    Medical condition: Hypertension, induced by the use of a Calcineurin Inhibitor (CNI)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-001214-40 Sponsor Protocol Number: cro085 Start Date*: 2007-08-17
    Sponsor Name:Imperial College London
    Full Title: A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivity
    Medical condition: Hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-000165-23 Sponsor Protocol Number: INFORM Start Date*: 2016-10-19
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
    Full Title: ComparIsoN oF Optimal Hypertension RegiMens (Part of the Ancestry Informative Markers in Hypertension (AIM HY) Programme – AIM HY-INFORM)
    Medical condition: Cardiovascular Hemodynamics
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004848 10005727 Blood pressure LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-003547-23 Sponsor Protocol Number: DAR-312 Start Date*: 2007-11-15
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension A Phase 3 Randomized, Double-Blind, Placebo- and Active-Controlled, Multi-center, Parallel Grou...
    Medical condition: Resistant hypertension
    Disease: Version SOC Term Classification Code Term Level
    8.1 10038274 Refractory hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) GB (Completed) DE (Completed) BE (Completed) DK (Completed) ES (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2019-002008-41 Sponsor Protocol Number: GR-MET-19 Start Date*: 2019-09-05
    Sponsor Name:AOU DI BOLOGNA POLICLINICO S.ORSOLA-MALPIGHI
    Full Title: Effect of metyrapone on cardiovascular risk factors in patients with adrenal incidentalomas and subclinical/mild Cushing's syndrome
    Medical condition: patients with adrenal incidentalomas and subclinical/mild Cushing’s syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10014698 - Endocrine disorders 10011652 Cushing's syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-002544-40 Sponsor Protocol Number: 5866 Start Date*: 2014-10-29
    Sponsor Name:Hôpitaux Universitaires de Strasbourg
    Full Title: THE TREATMENT OF HYPERTENSION ASSOCIATED WITH SEVERE PREECLAMPSIA. A RANDOMIZED CONTROLLED TRIAL OF URAPIDIL VERSUS NICARDIPINE. The URANIC trial.
    Medical condition: Hypertension associated with severe pre eclampsia
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-003647-28 Sponsor Protocol Number: NA Start Date*: 2020-12-09
    Sponsor Name:
    Full Title: Differences in antihypertensive drug levels in patients with hypertension: old vs young 2
    Medical condition: Hypertension Cardiovascular disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-021988-32 Sponsor Protocol Number: LUMI/10/ZOF- HYP/001 Start Date*: 2010-09-27
    Sponsor Name:LUSOFARMACO
    Full Title: A multicentre, multinational, randomised, double-blind, pilot, ascending dose for non responder, parallel group study on the therapeutic efficacy and safety of o.d. Zofenopril 30 mg plus HCTZ 12.5 ...
    Medical condition: elderly subjects (age > 65 years) affected by Isolated Systolic Hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050591 LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2009-015824-27 Sponsor Protocol Number: MeBN/06/NEB-CBP/001 Start Date*: 2009-12-23
    Sponsor Name:MENARINI Benelux NV/SA
    Full Title: The effects of Nebivolol/HCTZ on Central Arterial Pressure, a randomised double-blind cross-over trial
    Medical condition: Hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-000628-25 Sponsor Protocol Number: 23012008 Start Date*: 2008-05-13
    Sponsor Name:UMC Utrecht
    Full Title: The effectiveness of intensive treatment on sympathetic hyperactivity. A randomized, cross-over trial in patients with chronic kidney disease and hypertension
    Medical condition: Sympathetic nerve system in hypertensive patients with chronic kidney disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-005401-22 Sponsor Protocol Number: 24092007 Start Date*: 2009-02-20
    Sponsor Name:University Medical Center Utrecht
    Full Title: Effect of Aliskiren on Muscle Sympathetic Nerve Activity in hypertensive patients with chronic kidney disease
    Medical condition: Hypertension and chronic kidney disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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