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Clinical trials for Bone cells

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,571 result(s) found for: Bone cells. Displaying page 1 of 79.
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    EudraCT Number: 2006-006964-48 Sponsor Protocol Number: 20040215 Start Date*: 2007-04-13
    Sponsor Name:Amgen Inc
    Full Title: An Open-Label, Multi-Center, Phase 2 Safety and Efficacy Study of Denosumab (AMG 162) in Subjects with Recurrent or Unresectable Giant Cell Tumor (GCT) of Bone
    Medical condition: Giant Cell Tumor (GCT) of bone
    Disease: Version SOC Term Classification Code Term Level
    9.1 10005968 Bone giant cell tumor LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-018491-24 Sponsor Protocol Number: 31295 Start Date*: 2010-07-15
    Sponsor Name:Vrije Universiteit Medical Center
    Full Title: Effect of aminobisphosphonates and statins on circulating Vy9Vd2-T cells
    Medical condition: patients with malignant bone metastases
    Disease: Version SOC Term Classification Code Term Level
    12.1 10005993 Bone metastases LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017924-18 Sponsor Protocol Number: P10 Start Date*: 2011-01-04
    Sponsor Name:
    Full Title: Efficacy assessment of repeat intramyocardial injection of autologous bone marrow cells in previously responding no-option patients with residual refractory angina pectoris and documented ischemia
    Medical condition: In coronary artery disease atherosclerosis leads to a decrease in lumen diameter of the large epicardial arteries, causing a deficit in blood flow known as ischemia. This ischemia can cause chest p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-003691-40 Sponsor Protocol Number: LUMC2010-01 Start Date*: 2012-09-19
    Sponsor Name:Leiden University Medical Center
    Full Title: Administration of leukemia-reactive donor T cells after allogeneic stem cell transplantation or donor lymphocyte infusion to patients with persistent or relapsed mature B cell neoplasm with blood a...
    Medical condition: persistent or relapsed mature B cell neoplasm with blood and/or bone marrow involvement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006480-23 Sponsor Protocol Number: 10,176 Start Date*: 2007-10-12
    Sponsor Name:University Hospitals of Leicester
    Full Title: Autologous Bone Marrow-Derived Cells for Cardioprotection During Heart Surgery
    Medical condition: Improvement of cardioprotection during elective coronary artery bypass graft surgery using the patients own bone marrow cells.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-012189-30 Sponsor Protocol Number: BC1-09 Start Date*: 2009-10-30
    Sponsor Name:Algeta ASA
    Full Title: An open-label Phase IIa, non-randomised, study of Alpharadin in breast cancer patients with bone dominant disease who are no longer considered suitable for endocrine therapy
    Medical condition: Breast cancer patients with bone dominant disease who have progressed on endocrine therapy and are no longer considered suitable for further endocrine therapy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10027452 Metastases to bone LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-004046-41 Sponsor Protocol Number: 273551 Start Date*: 2021-12-09
    Sponsor Name:University of Bergen,
    Full Title: A multicentre clinical trial; Alveolar bone augmentation using Mesenchymal Stem Cells and biphasic calcium phosphate granules prior to dental implants
    Medical condition: Patients in need of dental implant(s) in the upper and lower jaws with presence of bone defects with loss in vertical height and < than 4 mm in lateral width
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019380-11 Sponsor Protocol Number: 09/0278 Start Date*: 2010-09-30
    Sponsor Name:
    Full Title: Autologous cell therapy of fracture non-union – cell phenotype as a predictor of outcome
    Medical condition: delayed fracture union (fracture non-union)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000595-33 Sponsor Protocol Number: 2011-01-01REPEAT Start Date*: 2013-04-25
    Sponsor Name:Goethe University Frankfurt
    Full Title: Randomized controlled trial to compare the effects of single versus repeated intracoronary application of autologous bone marrow-derived mononuclear cells on total and SHFM-predicted mortality in p...
    Medical condition: Chronic post-infarction heart failure due to an at least 3 months old myocardial infarction, treated with optimal medication according to the evidence-based guidelines, in NYHA stadium II-III; and ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Temporarily Halted) NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000431-32 Sponsor Protocol Number: ORTHOUNION Start Date*: 2017-05-25
    Sponsor Name:Universidad Autónoma de Madrid (U.A.M.)
    Full Title: A MULTI-CENTRE, OPEN-LABEL, RANDOMIZED, COMPARATIVE CLINICAL TRIAL OF TWO DIFFERENT DOSES OF BONE MARROW AUTOLOGOUS HUMAN MESENCHYMAL STEM CELLS PLUS BIOMATERIAL VERSUS ILIAC CREST AUTOLOGOUS GRAFT...
    Medical condition: Diaphyseal and/or metaphysodiaphyseal fractures (femur, tibia, humerus) with status of non-union
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10017085 Fracture malunion PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) DE (Completed) FR (Ongoing) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-003139-50 Sponsor Protocol Number: Maxillo1 Start Date*: Information not available in EudraCT
    Sponsor Name:University of Bergen, Faculty of medicin and dentistry, Dep. of Clinical Dentistry
    Full Title: International, multicenter phase II uncontrolled prospective clinical trial: Jaw bone reconstruction using a combination of biomaterial and autologous mesenchymal stem cells prior to dental impla...
    Medical condition: Men and women aged 18 years or more requiring jaw bone reconstruction prior to dental implant placement based on clinical and radiological examinations (CBCT Cone beam CT imaging). Areas suitable ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-005835-87 Sponsor Protocol Number: GBG41 Start Date*: 2006-08-16
    Sponsor Name:GermanBreastGroup
    Full Title: A randomized discontinuation phase II study to determine the efficacy of RAD001 in breast cancer patients with bone metastases
    Medical condition: Bone metasatsis, Breast cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-001227-39 Sponsor Protocol Number: 779322 Start Date*: 2019-12-11
    Sponsor Name:University of Bergen, Faculty of Medicin, Department of Clinical Dentistry
    Full Title: A randomized controlled clinical trial to assess the efficacy of a combination of autologous mesenchymal stem cells and biomaterial in jaw bone regeneration prior to dental implant placement in com...
    Medical condition: Patients in need of dental implant(s) in the upper and lower jaws with presence of bone defects with loss in vertical height and < than 4 mm in lateral width
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10005958 Bone disorder NOS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) NO (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006146-34 Sponsor Protocol Number: 100505 Start Date*: 2008-04-30
    Sponsor Name:Stage Pharmaceuticals GmbH
    Full Title: Adoptive Immunotherapy of chemotherapy refractory CMV infections using Streptamer-isolated T cells after allogeneic bone marrow or peripheral blood stem cell transplantation: a phase I/II trial
    Medical condition: -chronic persistent CMV infection after allogeneic bone marrow or peripheral blood stem cell transplantation, refractory to antiviral chemotherapy
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001820-51 Sponsor Protocol Number: BMC2012-PhaseII Start Date*: 2016-06-27
    Sponsor Name:Dekan der medizinischen Fakultät, Universitätsklinikum Frankfurt, Goethe-Universität
    Full Title: BMC2012, Cell based therapy by implanted bone marrow-derived mononuclear cells (BMC) for bone augmentation of plate-stabilized proximal humeral fractures - a randomized, open, multicentric study - ...
    Medical condition: Investigation of cell based therapy by implanted bone marrow-derived mononuclear cells for bone augmentation on osteosynthesis of proximal humeral fractures
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-002732-75 Sponsor Protocol Number: MSC-ACLrep Start Date*: 2021-02-01
    Sponsor Name:Alexander IV sp. Partnership Ortopedika Surgery Specialistic Center
    Full Title: The use of mesenchymal stem cells from the bone marrow stroma for reconstruction of the anterior cruciate ligament
    Medical condition: Rupture of the anterior cruciate ligament in the knee
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10049548 Knee operation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001825-28 Sponsor Protocol Number: T2DM-CLI-2012 Start Date*: 2012-08-20
    Sponsor Name:Fakultní nemocnice Ostrava,Czech Republic
    Full Title: Randomised clinical study of autologous bone marrow aspirate concentrate (BMAC) activity fo No_option_critical limb ischemia in Type-II diabetes mellitus (DILAEG)
    Medical condition: No-option critical limb ischemia patients with T2DM and foot ulcers
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-022072-31 Sponsor Protocol Number: R5242A789 Start Date*: 2013-04-15
    Sponsor Name:RJAH Orthopaedic Hospital
    Full Title: Autologous Cell Therapy for Osteoarthritis: An evaluation of the safety and efficacy of autologous transplantation of articular chondrocytes and/or bone marrow-derived stromal cells to repair chond...
    Medical condition: osteochondral defects of the knee (early osteoarthritis)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2011-005584-24 Sponsor Protocol Number: PREOB-NU3 Start Date*: 2012-05-10
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: A pivotal Phase IIb/III, multicentre, randomised, open, controlled study on the efficacy and safety of autologous osteoblastic cells (PREOB®) implantation in non-infected hypotrophic non-union frac...
    Medical condition: Non-infected hypotrophic non-union fractures of long bones
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10048617 Pseudarthrosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed) NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-012929-11 Sponsor Protocol Number: PREOB-ON3 Start Date*: 2011-10-17
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: Phase III, pivotal, multicentre, randomised, double-blind controlled Study to evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Os...
    Medical condition: Osteonecrosis of the Femoral Head
    Disease: Version SOC Term Classification Code Term Level
    18.1 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) DE (Completed) GB (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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