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Clinical trials for Children AND Pain

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    456 result(s) found for: Children AND Pain. Displaying page 1 of 23.
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    EudraCT Number: 2010-021406-38 Sponsor Protocol Number: Finaledition Start Date*: 2012-08-28
    Sponsor Name:Mariefreds Vårdcentral
    Full Title: EMLA CREAM AS PAIN RELIEF DURING PNEUMOCOCCAL VACCINATION
    Medical condition: Pain relief with Emla cream during Pneumococcal vaccination.
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000314-38 Sponsor Protocol Number: PSS2018/DEXPED-MEISTELMAN/YB Start Date*: 2018-09-11
    Sponsor Name:CHRU de NANCY
    Full Title: Efficiency of IV dexamethasone compared to placebo, administrated after a lower limb blockade is done, on the post operative pain in children : a controled, randomised, double blind study.
    Medical condition: post operative pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10002182 Analgesia LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-005416-42 Sponsor Protocol Number: KF001 Start Date*: 2015-05-08
    Sponsor Name:Uppsala University. Department of Women's and children's health
    Full Title: Clondine in repeated doses for children in pain - a farmacokinetic study
    Medical condition: Pain in children
    Disease: Version SOC Term Classification Code Term Level
    18.0 10018065 - General disorders and administration site conditions 10033371 Pain PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-002436-31 Sponsor Protocol Number: ALGIPED Start Date*: 2023-05-16
    Sponsor Name:Dicofarm S.p.A.
    Full Title: Randomized, controlled, transversal phase IV study on the efficacy and speed of action of lysin ibuprofen vs ibuprofen on the treatment of acute pain in children (ALGIPED).
    Medical condition: Acute pain in pediatric age
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004867 10066714 Acute pain LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Not Authorised)
    Trial results: (No results available)
    EudraCT Number: 2021-000137-14 Sponsor Protocol Number: PDC-01-0206 Start Date*: 2021-05-04
    Sponsor Name:Cessatech A/S
    Full Title: Pharmacokinetic study of intranasal CT001 in children 1-17 years of age undergoing elective surgical procedures
    Medical condition: Management of acute pain in children 1-17 years with the objective of preventing pain and distress associated with painful medical procedures in children.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10018065 - General disorders and administration site conditions 10033371 Pain PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2008-005441-34 Sponsor Protocol Number: 02none Start Date*: 2009-06-04
    Sponsor Name:Department of Anesthesia, University College Hospital Galway
    Full Title: Comparison of Transversus Abdominis Plane (TAP) block, Ilioinguinal Nerve Block and Surgical Infiltration for Orchidoplexy and Hydrocele Repair in Children.
    Medical condition: Comparison of Transversus Abdominis Plane (TAP) block, Ilioinguinal Nerve Block and Surgical Infiltration for Orchidoplexy and Hydrocele Repair in Children.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054711 Postoperative pain LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-001170-92 Sponsor Protocol Number: 16787 Start Date*: 2007-09-12
    Sponsor Name:Erasmus MC
    Full Title: Dexamethasone for postoperative pain relief following tonsillectomy in children
    Medical condition: (Adeno)Tonsillectomy and Pain
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003690-65 Sponsor Protocol Number: 78304 Start Date*: 2021-11-10
    Sponsor Name:St Antonius Hospital
    Full Title: Peppermint Oil for the treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT study
    Medical condition: Irritable Bowel syndrome Functional Abdominal Pain Not otherwise specified
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014983-20 Sponsor Protocol Number: DIA001 Start Date*: 2010-02-25
    Sponsor Name:Wockhardt UK Limited
    Full Title: An open label single dose pharmacokinetic study of Diamorphine Hydrochloride Nasal Spray (0.06mg/kg) in children
    Medical condition: The IMP is to be used as an analgesic for the relief of acute pain.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10002182 Analgesia LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-004057-25 Sponsor Protocol Number: RC21/18 Start Date*: 2019-10-02
    Sponsor Name:IRCCS MATERNO INFANTILE BURLO GAROFOLO
    Full Title: Oral Ibuprofene versus oral kethorolac for children with musculoskeletal injury: a double blind randomized controlled study.
    Medical condition: Pain is present in 78% of overall accesses in pediatric emergency rooms and, in most cases, it is acute and secondary to musculoskeletal trauma. Fifthy percent of patients report moderate to severe...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10033472 Pain of extremties LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014982-16 Sponsor Protocol Number: DIA002 Start Date*: 2010-02-25
    Sponsor Name:Wockhardt UK Limited
    Full Title: An open label, single dose safety study of Diamorphine Hydrochloride Nasal Spray (0.1mg/kg) in children
    Medical condition: The IMP is to be used as an analgesic for the relief of acute pain.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10002182 Analgesia LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-004497-33 Sponsor Protocol Number: Protocol_Dysport_v3__13.12.2017 Start Date*: 2018-03-06
    Sponsor Name:Copenhagen University Hospital at Hvidovre
    Full Title: Measuring effects on pain and quality of life after Dysport® injection in children with cerebral palsy
    Medical condition: Muscle pain in the extremities due to spasticity in children with cerebral palsy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10028322 Muscle pain LLT
    20.0 100000004852 10041418 Spasticity muscle LLT
    20.1 100000004850 10021745 Infantile cerebral palsy, unspecified LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-003231-71 Sponsor Protocol Number: NOT APPLICABLE Start Date*: 2006-12-08
    Sponsor Name:Dept of Anaesthesia, University College Hospital, Galway
    Full Title: Determination of the efficacy of the Transversus Abdominis Plane Block in the management of postoperative pain in children post open abdominal surgery.
    Medical condition: Postoperative pain in children post open abdominal surgery
    Disease: Version SOC Term Classification Code Term Level
    8.1 10054711 Postoperative pain LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-002016-27 Sponsor Protocol Number: KF5503/68 Start Date*: 2015-03-23
    Sponsor Name:Grünenthal GmbH
    Full Title: Open-label evaluation of the pharmacokinetic profile, safety, and efficacy of tapentadol oral solution for the treatment of post-surgical pain in children and adolescents aged from 2 years to less ...
    Medical condition: Postoperative Pain
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10036236 Postoperative pain relief LLT
    17.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2014-002215-42 Sponsor Protocol Number: 22/13 Start Date*: Information not available in EudraCT
    Sponsor Name:IRCCS Burlo Garofolo
    Full Title: Single-blind randomized controlled trial for acute abdomen analgesia in Pediatric Emergency department
    Medical condition: Analgesia in pediatric acute abdominal pain
    Disease: Version SOC Term Classification Code Term Level
    17.0 10017947 - Gastrointestinal disorders 10000081 Abdominal pain PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005467-32 Sponsor Protocol Number: n.a. Start Date*: 2016-08-08
    Sponsor Name:Haga Teaching Hospital
    Full Title: A randomised controlled trial on the effect of laxative therapy in children with functional abdominal pain
    Medical condition: Functional abdominal pain
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001400-16 Sponsor Protocol Number: 6-1/05/1 Start Date*: 2021-07-02
    Sponsor Name:Riga Stradins university
    Full Title: Investigation of pain syndrome and clinical-biochemical parameters in 7 to 18 years old children with acute uncomplicated appendicitis who received non-surgical treatment.
    Medical condition: Pain syndrome in 7 to 18 years old children with acute uncomplicated appendicitis, who received non-surgical treatment.
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: LV (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-000379-96 Sponsor Protocol Number: INnaloxonePed-1 Start Date*: 2017-05-05
    Sponsor Name:Karolinska University Hospital
    Full Title: Pharmacokinetic and pharmacodynamic aspects in children after intranasal administration of the opioid antagonist naloxone
    Medical condition: Pharmacokinetic profile after nasal naloxone administration in Children. In second part study reversal of sedation after opioid use
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001615-78 Sponsor Protocol Number: F1J-MC-HMGW Start Date*: 2018-05-02
    Sponsor Name:
    Full Title: Effect of Duloxetine 30/60 mg Once Daily Versus Placebo in Adolescents With Juvenile Primary Fibromyalgia Syndrome
    Medical condition: Juvenile Primary Fibromyalgia Syndrome
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2015-003293-32 Sponsor Protocol Number: Duski2015 Start Date*: 2017-11-06
    Sponsor Name:Academic Medical Center
    Full Title: Multicentre, Randomised, Placebo-Controlled Trial of Mebeverine in Children with Irritable Bowel Syndrome (IBS) or Functional Abdominal Pain - not otherwise specified (FAP-NOS)
    Medical condition: Functional Gastrointestinal Disorders (Irritable Bowel Syndrome or Functional Abdominal Pain - not otherwise specified)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10064907 Functional abdominal pain LLT
    20.1 10017947 - Gastrointestinal disorders 10023003 Irritable bowel syndrome PT
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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