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Clinical trials for Controlled release

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    742 result(s) found for: Controlled release. Displaying page 1 of 38.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2015-002403-29 Sponsor Protocol Number: DAM001DFM Start Date*: 2017-04-25
    Sponsor Name:Di-AcetylM B.V.
    Full Title: Pharmacokinetics of new dexamphetamine sustained release tablets and the clinical validation of measuring dexamphetamine in dried blood spots
    Medical condition: No condition is investigated. The primary aim is to investigate the pharmacokinetics of the new formulation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-004160-16 Sponsor Protocol Number: PBKV.8zdnia01.06.2022 Start Date*: 2024-02-22
    Sponsor Name:The Pharmaceutical Company LEK-AM Sp. Zoo.
    Full Title: A randomized, double-blind, placebo-controlled, multicenter study evaluating the effect of a 12-week DHEA combination of 20 mg and 2 mg prolonged-release melatonin on sleep quality an...
    Medical condition: Menopause, sleep disorders in the postmenopausal period
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2004-004409-24 Sponsor Protocol Number: AK130940 Start Date*: 2005-06-08
    Sponsor Name:GlaxoSmithKline Research & Development
    Full Title: A Multi-Centre, Randomised, Double-Blind, Parallel-Group, Placebo-Controlled, Flexible Dose Study to Evaluate the Efficacy, Safety and Tolerability of Extended-Release Bupropion Hydrochloride (150m...
    Medical condition: Major Depressive Disorder (MDD)
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SK (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2004-003803-19 Sponsor Protocol Number: WXL101497 Start Date*: 2004-11-10
    Sponsor Name:GlaxoSmithKline Research & Development
    Full Title: A Multi-Centre, Randomised, Double-Blind, Parallel-Group, Placebo- and Active- Controlled, Flexible Dose Study Evaluating the Efficacy, Safety and Tolerability of Extended-Release Bupropion Hydroch...
    Medical condition: Major Depressive Disorder (MDD)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2007-001313-42 Sponsor Protocol Number: OXN2001 (Inc. Amd 3) Start Date*: 2007-11-02
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: A randomised, double-blind, active-controlled, double-dummy, parallel group study to determine the safety and efficacy of oxycodone / naloxone prolonged release tablets in subjects with moderate to...
    Medical condition: subjects with moderate to severe, chronic cancer pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    9.1 10058019 Cancer pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) CZ (Completed) DE (Completed) HU (Completed) FR (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2011-002235-26 Sponsor Protocol Number: OTR3002 Start Date*: 2011-10-26
    Sponsor Name:Purdue Pharma L.P.
    Full Title: An Open-label, Extension Study to Assess the Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Opioid Experienced Children Who Completed the OTR3001 Study
    Medical condition: Opioid experienced paediatric patients aged 6-17 years with moderate to severe malignant and/or nonmalignant pain requiring opioid therapy.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10002182 Analgesia LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) EE (Completed) ES (Completed) FI (Completed) DE (Completed) GR (Prematurely Ended) GB (Prematurely Ended) SK (Completed) BE (Completed) HU (Prematurely Ended) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-005024-40 Sponsor Protocol Number: NPP100023 Start Date*: 2005-04-06
    Sponsor Name:GlaxoSmithKline Research and Development Ltd
    Full Title: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF LAMOTRIGINE 200-400MG/DAY COMPARED WITH PLACEBO IN SUBJECTS WITH PAINFUL DIA...
    Medical condition: Painful Diabetic Neuropathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) LV (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-002274-41 Sponsor Protocol Number: MCL-metoprolol-CR Start Date*: 2013-07-11
    Sponsor Name:Medisch Centrum Leeuwaarden
    Full Title: The effect of Roux-en-Y gastric bypass on the rate and extent of absorption of metoprolol from a controlled release tablet in female bariatric patient volunteers: a single oral dose study before an...
    Medical condition: Roux-en-Y gastric bypass
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-007877-22 Sponsor Protocol Number: 2007IC013H Start Date*: 2008-07-10
    Sponsor Name:Royal Brompton & Harefield NHS Trust
    Full Title: A prospective blinded randomised placebo controlled trial investigating whether oxycodone modified release reduces parenteral opioid use following intermediate thoracic surgery
    Medical condition: The management of acute pain after intermediate thoracic surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066714 Acute pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-002260-25 Sponsor Protocol Number: OXC-008/K (22DN0866) Start Date*: 2005-07-18
    Sponsor Name:Desitin Arzneimittel GmbH
    Full Title: A randomized, phase III, double blind, active-controlled, two-armed, multi-center study on efficacy and safety of once-daily oxcarbazepine (-modified release formulation) versus twice-daily oxcarba...
    Medical condition: Partial onset epilepsy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2004-004208-19 Sponsor Protocol Number: CXUO320B2406 Start Date*: 2005-05-04
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 12-week multicentre, double blind, double dummy, randomized, parallel group, active controlled study to evaluate the efficacy and tolerability of fluvastatin extended release (Lescol XL® 80 mg) a...
    Medical condition: Dyslipidemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-013268-38 Sponsor Protocol Number: FLUPI-7018 Start Date*: 2009-09-29
    Sponsor Name:AWD.pharma GmbH & Co KG
    Full Title: A multicentre, double-blind, randomised, active- and placebo-controlled clinical trial on the pain relieving effects of the modfied-release formulation of flupirtine in patients suffering from mode...
    Medical condition: chronic low back pain
    Disease: Version SOC Term Classification Code Term Level
    12.0 10024891 Low back pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-004385-16 Sponsor Protocol Number: ME/2005/2073 Start Date*: 2006-01-03
    Sponsor Name:United Bristol Healthcare NHS Trust
    Full Title: CIRCADIAN VARIATIONS IN CYTOKINES AND THE EFFECT OF TIMED RELEASE TABLET PREDNISONE IN RHEUMATOID ARTHRITIS
    Medical condition: Rheumatoid arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-000193-77 Sponsor Protocol Number: 05/Q1405/78 Start Date*: 2007-03-20
    Sponsor Name:The University of Manchester
    Full Title: Protective analgesia using bupivacaine and conventional release ibuprofen versus bupivacaine and sustained release ibuprofen for postoperative pain relief in patients undergoing third molar surgery...
    Medical condition: Pain following surgical removal of impacted lower wisdom tooth/ teeth.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023992-24 Sponsor Protocol Number: MEMAP1 Start Date*: 2011-08-26
    Sponsor Name:University of Leipzig
    Full Title: International randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Medical condition: acute mania and hypomania (ICD-10: F30.0, F30.1, F31.0, F31.1)
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004873 10000852 Acute mania LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Prematurely Ended) BE (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2012-005063-28 Sponsor Protocol Number: Emend2 Start Date*: 2013-10-02
    Sponsor Name:University of Gothenburg
    Full Title: Release of substance P during peritoneal dialysis: effects of intervention. Controlled cross-over study of the neurokinin-1 receptor antagonist Aprepitant
    Medical condition: End stage renal disease under treatment with peritoneal dialysis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017843-32 Sponsor Protocol Number: LOL-III-1 Start Date*: 2010-10-14
    Sponsor Name:Foundation of Liver Research (SLO)
    Full Title: A multi-center randomized, open label, controlled study in primary liver transplantation comparing long term renal function and development of de novo malignancy in recipients treated with standard...
    Medical condition: Liver transplantation
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10050434 Prophylaxis against liver transplant rejection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-000889-22 Sponsor Protocol Number: ICKTI08TX01 Start Date*: 2008-11-11
    Sponsor Name:Imperial College Healthcare NHS Trust
    Full Title: A randomised controlled comparison of standard release Tacrolimus vs extended-release Tacrolimus as baseline maintenance monotherapy for kidney transplantation after induction with Campath 1-H.
    Medical condition: Prevention of allograft rejection after renal transplantation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023439 Kidney transplant rejection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-002260-10 Sponsor Protocol Number: MCL-metoprolol-IR Start Date*: 2013-07-11
    Sponsor Name:Medisch Centrum Leeuwarden
    Full Title: The effect of Roux-en-Y gastric bypass on the rate and extent of absorption of metoprolol from an immediate release tablet in female bariatric patient volunteers: a single oral dose study before an...
    Medical condition: Roux-en-Y gastric bypass
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002959-41 Sponsor Protocol Number: FLUPI-5014 Start Date*: 2005-10-10
    Sponsor Name:AWD.pharma GmbH & Co. KG; Medical Development
    Full Title: A multicentre, double-blind, randomised, placebo-controlled clinical trial to investigate pain relieving effects of the modified release (MR) formulation of flupirtine in patients suffering from mo...
    Medical condition: chronic low back pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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