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Clinical trials for Cough

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    798 result(s) found for: Cough. Displaying page 1 of 40.
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    EudraCT Number: 2008-004143-11 Sponsor Protocol Number: 33103 Start Date*: 2008-12-17
    Sponsor Name:The University of Nottingham
    Full Title: Are macrolide antibiotics effective in chronic idiopathic cough?
    Medical condition: idiopathic chronic cough, defined as cough with no identifiable cause and which has been present for at least 2 monhs.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011224 Cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-000306-36 Sponsor Protocol Number: XEN-D0501-CL-04 Start Date*: 2014-05-20
    Sponsor Name:Xention Limited
    Full Title: A double-blind, randomised, placebo-controlled, crossover study to assess the efficacy of XEN D0501, a TRPV1 antagonist, in reducing the frequency of cough in patients with chronic idiopathic cough
    Medical condition: Chronic Idiopathic Cough
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-005074-11 Sponsor Protocol Number: 14/GAR/002 Start Date*: 2015-04-29
    Sponsor Name:University Hospital South Manchester NHS Foundation Trust
    Full Title: The Role of GABAb receptor mechanisms in cough: Double-blind randomised controlled trial of Lesogaberan in Chronic cough patients with positive and negative symptom association probabilities
    Medical condition: Chronic cough
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-004136-17 Sponsor Protocol Number: BUS-P2-02 Start Date*: 2021-02-05
    Sponsor Name:Bellus Health Inc.
    Full Title: A Randomized, Adaptive, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2b Study to Evaluate the Efficacy and Safety of Multiple Doses of BLU-5937 in Adult Participants With Refractory Chro...
    Medical condition: Refractory Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) DE (Completed) CZ (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-005533-38 Sponsor Protocol Number: ABR 14828 Start Date*: 2007-06-28
    Sponsor Name:there is no sponsor.
    Full Title: 'Studies in patients with chronic cough; montelukast and amitriptyline studies’.
    Medical condition: Chronic cough ( cough lasting > 8 weeks).
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003980-36 Sponsor Protocol Number: IIT15419 Start Date*: 2018-01-26
    Sponsor Name:Hull and East Yorkshire Hospitals NHS Trust
    Full Title: A single-Centre, open-label, exploratory study of the effect of 20 mg ambroxol hydrochloride on cough reflex sensitivity in patients with acute cough.
    Medical condition: acute cough assouciated with URTI
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10066522 Acute cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-002283-27 Sponsor Protocol Number: 1812VA323 Start Date*: 2020-03-18
    Sponsor Name:Shionogi B.V.
    Full Title: A phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose selection study of S-600918 in patients with refractory chronic cough
    Medical condition: Refractory chronic cough
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) CZ (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2017-003250-16 Sponsor Protocol Number: MTI-110 Start Date*: 2017-12-11
    Sponsor Name:Menlo Therapeutics Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study Of The Efficacy, Safety, And Tolerability Of Serlopitant For The Treatment Of Refractory Chronic Cough
    Medical condition: Refractory Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-019647-19 Sponsor Protocol Number: MAC_001 Start Date*: 2011-02-04
    Sponsor Name:University of Oxford
    Full Title: A double blind randomised placebo controlled trial of montelukast in the treatment of acute persistent cough in young people and adults (aged 16-49) in primary care
    Medical condition: Acute persistent cough with no established diagnosis
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-024283-18 Sponsor Protocol Number: AF219-006 Start Date*: 2011-05-20
    Sponsor Name:Afferent Pharmaceuticals, Inc.
    Full Title: A Study to Assess the Efficacy of AF-219, a P2X3 Receptor Antagonist, in Subjects with Chronic Cough
    Medical condition: Subjects with Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005151-13 Sponsor Protocol Number: MEM-COUGH-01 Start Date*: 2012-05-17
    Sponsor Name:University of Manchester [...]
    1. University of Manchester
    2. University Hospital of South Manchester
    Full Title: Open-label Pilot Study of Memantine in Chronic Cough Patients Attending a Specialist Clinic
    Medical condition: Idiopathic and treatment resistant Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-022472-31 Sponsor Protocol Number: Lidocaine1 Start Date*: 2010-12-23
    Sponsor Name:University Hospital of South Manchester
    Full Title: The effect of Lidocaine and its Delivery in Patients with Chronic Cough
    Medical condition: Chronic Cough
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-002308-42 Sponsor Protocol Number: MK-7264-043 Start Date*: 2019-12-20
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.,Inc
    Full Title: A Phase 3b Randomized, Double-blind, Placebo Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Gefapixant in Adult Participants with Recent Onset Chronic Cough
    Medical condition: Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (GB - no longer in EU/EEA) PL (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-004589-14 Sponsor Protocol Number: BC1036-001 Start Date*: 2012-05-17
    Sponsor Name:Respicopea Limited
    Full Title: A Multicentre, Double-Blind, Placebo-Controlled, Adaptive Pivotal Study of the Efficacy and Safety of Oral BC1036 in the Management of Cough
    Medical condition: Chronic and sub acute persistent cough
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10066656 Chronic cough LLT
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10070801 Persistent cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003947-36 Sponsor Protocol Number: NT2014/Orv/Prot001 Start Date*: 2015-01-12
    Sponsor Name:NeRRe Therapeutics Ltd
    Full Title: Evaluation of orvepitant in an exploratory open-label clinical study in chronic treatment-refractory cough
    Medical condition: Chronic treatment-refractory cough
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-011525-13 Sponsor Protocol Number: V001 Start Date*: 2009-08-28
    Sponsor Name:Vernalis (R&D) Limited
    Full Title: Phase II Open-label Pilot Study of V3381, a Novel N-Methyl-D-Aspartate Receptor Antagonist, in Chronic Cough Patients attending a Specialist Clinic
    Medical condition: Treatment resistant and Idiopathic Chronic Cough
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-000866-11 Sponsor Protocol Number: 7164-L-01 Start Date*: 2004-08-06
    Sponsor Name:ZAMBON GROUP
    Full Title: A multicenter, randomized, parallel group, controlled, double-blind study to evaluate efficacy and safety of pholcodine as antitussive agent vs dextrometorphan in non-productive cough
    Medical condition: Symptomatic treatment of non productive cough
    Disease: Version SOC Term Classification Code Term Level
    6.1 10011224 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-004025-40 Sponsor Protocol Number: PA101-CC-02 Start Date*: 2015-02-06
    Sponsor Name:Patara Pharma
    Full Title: Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.
    Medical condition: Chronic Idiopathic Cough and Chronic Cough in Idiopathic Pulmonary Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004855 10066656 Chronic cough LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002034-47 Sponsor Protocol Number: AF219-014 Start Date*: 2015-10-12
    Sponsor Name:Afferent Pharmaceuticals, Inc.
    Full Title: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects
    Medical condition: Chronic cough
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-004255-31 Sponsor Protocol Number: IFH-2014-004 Start Date*: 2014-12-02
    Sponsor Name:infirst HEALTHCARE
    Full Title: A real world, single-blind, randomised study to compare an OTC cough medicine (cs1002) containing diphenhydramine, levomenthol and ammonium chloride with a simple linctus containing citric acid mon...
    Medical condition: acute cough
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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