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Clinical trials for Denervation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    13 result(s) found for: Denervation. Displaying page 1 of 1.
    EudraCT Number: 2017-003117-25 Sponsor Protocol Number: V3.0 Start Date*: 2018-05-17
    Sponsor Name:Medical University of Vienna
    Full Title: Longitudinal chemodenervation effects of botulinum toxin A after intramuscular application and the impact of physical activity
    Medical condition: Spastic hemiparesis with involvement of the M. biceps brachii
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000036-96 Sponsor Protocol Number: CR0014 Start Date*: 2018-09-06
    Sponsor Name:Ablative Solutions, Inc.
    Full Title: A Phase 2, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit, in Subjects with Hypertension, in the Absence of Antihypertensive Medications
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10020772 Hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (GB - no longer in EU/EEA) DE (Completed) IE (Completed) NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002545-32 Sponsor Protocol Number: CR0002 Start Date*: 2019-11-06
    Sponsor Name:Ablative Solutions, Inc
    Full Title: A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System™ Kit, in Subjects with Hypertension.
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10020772 Hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) FR (Ongoing) SE (Ongoing) BE (Ongoing) NL (Ongoing) IE (Ongoing) PL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001066-14 Sponsor Protocol Number: DENERVHTA Start Date*: 2012-07-17
    Sponsor Name:Consorci Mar Parc de salut de Barcelona ( Parc de Salut Mar)
    Full Title: Sympathetic renal denervation versus increment of pharmacological treatment in resistant arterial hypertension
    Medical condition: subjects with resistant hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-018226-29 Sponsor Protocol Number: botox2010 Start Date*: 2010-04-20
    Sponsor Name:
    Full Title: The effect of botulinum toxin type A injections in the m. rectus femoris in stroke patients presenting with a stiff knee gait.
    Medical condition: Stroke patients with stiff knee gait. Stiff knee gait is characterized as a diminished knee flexion during swing phase of gait. It is common in stroke patients.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004995-13 Sponsor Protocol Number: 38372 Start Date*: 2012-02-09
    Sponsor Name:Erasmus MC
    Full Title: Endovascular renal sympathetic denervation versus spironolactone for treatment-resistant hypertension: a randomized, multicentric study
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.0 10047065 - Vascular disorders 10020772 Hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003014-22 Sponsor Protocol Number: Thalamus_V3 Start Date*: 2018-06-25
    Sponsor Name:Medical University of Vienna
    Full Title: The role of leptin in regulating hepatic lipid metabolism in humans
    Medical condition: lipodystrophy patients, patients after liver transplantation and healthy controls
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-003915-11 Sponsor Protocol Number: CarniValI (Uni-Koeln-1107) Start Date*: 2009-09-24
    Sponsor Name:University of Utah
    Full Title: Phase I/II Trial of Valproic Acid and Carnitine in Infants with Spinal Muscular Atrophy Type I (CARNI-VAL Type I)
    Medical condition: Spinal Muscular Atrophy Type I in infants
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051203 Spinal muscular atrophy congenital LLT
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-004636-66 Sponsor Protocol Number: KP-2011-0077 Start Date*: 2011-12-05
    Sponsor Name:Uppsala University Hospital
    Full Title: Single-blinded randomized trial of Botulinumtoxin A (Vistabel®) and its objective paralytic effect in the facial muscles of healthy women: development of new neurophysiological measurements.
    Medical condition: The treatment of glabellar lines in healthy women by muscle paralysis from injection of botulinum toxin
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-002499-42 Sponsor Protocol Number: Version1on02-02-2018 Start Date*: 2018-08-29
    Sponsor Name:Cliniques Universitaires Saint-Luc
    Full Title: Evaluation of the effect of repeated injections of high doses of botulinum toxin into the lower limb of spastic brain lesions on functional and biomechanical parameters of walking
    Medical condition: Patients with spastic brain lesions. Children with cerebral palsy (CP) and in the hemiplegic adult.
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006614-37 Sponsor Protocol Number: CryoStopPersAF Start Date*: 2022-05-11
    Sponsor Name:Region Örebro
    Full Title: First-line cryoablation for early treatment of Persistent Atrial Fibrillation – a randomized study comparing early trigger isolation using the Cryoballoon versus antiarrhythmic medication.
    Medical condition: Persistent symptomatic atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    25.1 100000004865 10081865 Cardiac catheter ablation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-012836-33 Sponsor Protocol Number: KIP113049 Start Date*: 2009-11-26
    Sponsor Name:GlaxoSmithKline Research & Development Limited
    Full Title: A randomised, double blind study to evaluate the safety and efficacy of the p38 kinase inhibitor, GW856553, in subjects with neuropathic pain from lumbosacral radiculopathy
    Medical condition: Neuropathic pain from lumbosacral radiculopathy
    Disease: Version SOC Term Classification Code Term Level
    12.0 10037779 Radiculopathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DE (Completed) DK (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-018157-23 Sponsor Protocol Number: D0490C00014 Start Date*: 2010-11-30
    Sponsor Name:AstraZeneca AB
    Full Title: A Phase IIa, Multi-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group 12-Month Treatment, Adaptive Design Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics ...
    Medical condition: Multiple system atrophy
    Disease: Version SOC Term Classification Code Term Level
    12.1 10064060 Multiple system atrophy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Prematurely Ended) AT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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