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Clinical trials for Endothelial function

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    379 result(s) found for: Endothelial function. Displaying page 1 of 19.
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    EudraCT Number: 2014-000254-11 Sponsor Protocol Number: 33375 Start Date*: 2014-03-28
    Sponsor Name:Department of Neurology
    Full Title: ROLE OF ENDOTHELIAL INFLAMMATION IN DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM
    Medical condition: Mulple Sclerosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-000551-15 Sponsor Protocol Number: MTXa54 Start Date*: 2005-09-05
    Sponsor Name:University of Dundee
    Full Title: Effect of folic acid supplementation and allopurinol on endothelial function in patients with rheumatoid arthritis treated with methotrexate
    Medical condition: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory polyarthritis associated with excess cardiovascular (CV) mortality. Hyperhomocysteinaemia is recognized as an independent CV risk fact...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-006234-34 Sponsor Protocol Number: CD07/8396 Start Date*: 2008-08-18
    Sponsor Name:University of Leeds
    Full Title: 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: endothelial and endothelial progenitor cell function in men
    Medical condition: Objectives:To investigate whether statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) improve endothelial dysfunction in healthy volunteers (men). Endothelial dysfunction is an ear...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-001738-29 Sponsor Protocol Number: RGHT000502 Start Date*: 2009-03-20
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Renin angiotensin Aldosterone (RAAS) axis, endothelial function and hypertension: diagnostic strategies and therapeutic role of potassium supplementation
    Medical condition: We are seeking to determine the effects of potassium supplementation vs placebo for 6 weeks on the renin-angiotensin-aldosterone axis and also endothelial function in subjects with 10-20% 10 year ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-003775-21 Sponsor Protocol Number: ALH2 Start Date*: 2008-08-14
    Sponsor Name:Salford Royal Hospitals NHS Trust [...]
    1. Salford Royal Hospitals NHS Trust
    2. University of Manchester
    Full Title: Effects of atorvastatin on microcirculatory endothelial function in patients with systemic sclerosis
    Medical condition: Systemic sclerosis (also termed 'scleroderma')
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-014643-36 Sponsor Protocol Number: MeBe/08/NEB-MICR/001 Start Date*: 2010-04-23
    Sponsor Name:MENARINI Benelux NV/SA
    Full Title: Effects Of The Administration Of Nebivolol Versus Carvedilol On Microcirculatory Endothelial Function, Arterial Stiffness And Wave Reflection In Healthy Volunteers” (NeCaMic-study)
    Medical condition: Microcirculatory Endothelial Function, Arterial Stiffness And Wave Reflection
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2022-000174-25 Sponsor Protocol Number: 101090401IN Start Date*: 2023-03-17
    Sponsor Name:SANTEN INCORPORATED
    Full Title: A Phase IIa, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared with Vehi...
    Medical condition: Fuchs Endothelial Corneal Dystrophy (FECD)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004850 10014823 Endothelial corneal dystrophy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-002023-32 Sponsor Protocol Number: Niaspan Start Date*: 2007-10-05
    Sponsor Name:Charité - Universitätsmedizin Berlin
    Full Title: Niaspan for the treatment of endothelial dysfunction in patients without hyperlipoproteinemia
    Medical condition: Patients in this study do have symptomes like dyspnea, reduced maximum stress and do have a weakness feeling. We are analysing the endothelial function via the FMD-methode: Before and after a Niasp...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-016855-23 Sponsor Protocol Number: CD09/9088 Start Date*: 2010-08-20
    Sponsor Name:University of Leeds
    Full Title: Targeting systemic inflammation to improve endothelial function in obesity
    Medical condition: Healthy volunteer trial in obese subjects (body mass index 30 or greater) in which the IMP will be used to reduce inflammation by inhibiting tumour necrosis factor(TNF)-α in order to assess the eff...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-002579-17 Sponsor Protocol Number: WR 01102004 Start Date*: 2006-11-08
    Sponsor Name:Medizinische Klinik B, Herzzentrum Ludwigshafen
    Full Title: A double-blind, randomised placebo controlled study of the effects of Acarbose on endothelial function, hemostatic and fibrinolytic plasmatic factors in patients with stable coronary artery disease...
    Medical condition: 1. To study the effect of Acarbose treatment on endothelial function as a potential mechanism for the beneficial effects of better postprandial glycemic control in patients with impaired glucose to...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001196-46 Sponsor Protocol Number: OPHT-240215 Start Date*: 2015-05-15
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of simvastatin withdrawal on ocular endothelial function
    Medical condition: endothelial dysfunction in cardiovascular diseases
    Disease: Version SOC Term Classification Code Term Level
    19.1 10047065 - Vascular disorders 10048554 Endothelial dysfunction PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2007-007474-33 Sponsor Protocol Number: HS 01/07 Start Date*: 2008-06-12
    Sponsor Name:Dr. Harald Dobnig, Medizinische Univ. Klinik Graz, Abteilung für Endokrinologie und Nuklearmedizin
    Full Title: Prospective, placebo-controlled trial of vitamin D supplementation in patients with low-levels of 25-OH vitamin D to evaluate changes in markers of cardiovascular risk
    Medical condition: low levels of 25-OH vitamin D
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-018190-31 Sponsor Protocol Number: V1.0,14.12.2009 Start Date*: 2010-08-03
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik f.Innere Medizin II, Abt.f.Angiologie
    Full Title: OMEGA-3-POLYUNSATURATED FATTY-ACIDS (n3-PUFA) IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE: EFFECTS ON ENDOTHELIAL FUNCTION – A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL
    Medical condition: peripheral arterial disease (PAD) and intermittent claudication (IC)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018619-14 Sponsor Protocol Number: Lira-Vasc-001 Start Date*: 2010-03-31
    Sponsor Name:ikfe GmbH
    Full Title: Impact of Liraglutide on Endothelial Function and Microvascular Blood Flow in Type 2 Diabetes Mellitus
    Medical condition: Type 2 Diabetes Mellitus
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004450-28 Sponsor Protocol Number: T109/2012 Start Date*: 2013-02-18
    Sponsor Name:University of Turku [...]
    1. University of Turku
    2. Turku University Hospital
    Full Title: Effect of chemotherapy on endothelial function in patients with testicular cancer
    Medical condition: Testicular cancer
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004864 10043362 Testis neoplasm malignant LLT
    14.1 100000004864 10043321 Testicular germ cell cancer NOS LLT
    Population Age: Adults Gender: Male
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-003861-34 Sponsor Protocol Number: 0/2004 Start Date*: 2005-06-08
    Sponsor Name:Department of Nuclear Medicine
    Full Title: Influence of the PPAR gamma -agonist Pioglitazone on endothelial function in the peripheral and myocardial vascular territories and on myocardial efficiency in obese subjects
    Medical condition: There is an association between insulin resistance and endothelial dysfunction which is thought to be a critical factor in the development of vascular disease and thus an important factor in the de...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005045-17 Sponsor Protocol Number: 74983 Start Date*: 2022-04-05
    Sponsor Name:AMC
    Full Title: Resuscitation for repair of endothelial permeability in endotoxemia
    Medical condition: Acute critical illnes requiring volume resuscitation with fluids (e.g. Sepsis).
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-003916-74 Sponsor Protocol Number: EC08/00123 Start Date*: 2009-03-04
    Sponsor Name:Hospital Son Dureta
    Full Title: Estudio piloto de la eficacia de las estatinas en el tratamiento de la enfermedad pulmonar obstructiva crónica. (Pilot study on the efficacy of statins for the treatment of Chronic Obstructive Pul...
    Medical condition: Evaluar en la EPOC estable el efecto de la simvastatina sobre: (1) la función endotelial; (2) la inflamación pulmonar y sistémica; y, (3) el índice BODE (B: masa corporal, O: obstrucción bronquial,...
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006887-44 Sponsor Protocol Number: RGHT000396 Start Date*: 2007-06-19
    Sponsor Name:Royal Group Hospitals Trust
    Full Title: Non-invasive bed-side measurement of systemic endothelial function in patients undergoing abdominal aortic aneurysm repair; modulation by ascorbic acid
    Medical condition: Abdominal Aortic Aneurysm
    Disease: Version SOC Term Classification Code Term Level
    9.1 10049871 Abdominal aortic aneurysm haemorrhage LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-002293-54 Sponsor Protocol Number: Apex01version6 Start Date*: 2007-11-29
    Sponsor Name:University of Dundee
    Full Title: The APEX Trial: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients with Cardiac Syndrome X
    Medical condition: Patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriograms)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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