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Clinical trials for Essential medicines

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    179 result(s) found for: Essential medicines. Displaying page 1 of 9.
    1  2  3  4  5  6  7  8  9  Next»
    EudraCT Number: 2004-004061-15 Sponsor Protocol Number: SPD422-403 Start Date*: 2005-07-07
    Sponsor Name:Shire Pharmaceutical Development Ltd.
    Full Title: A Phase IIIb, randomised, open label study to compare the safety, efficacy and tolerability of anagrelide hydrochloride versus hydroxyurea in high-risk essential thrombocythaemia patients.
    Medical condition: Essential thrombocythaemia (ET)
    Disease: Version SOC Term Classification Code Term Level
    7.1 10015493 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) IE (Completed) ES (Completed) IT (Completed) SK (Completed) CZ (Completed) SI (Completed) BG (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2016-002885-30 Sponsor Protocol Number: ARES Start Date*: 2017-07-27
    Sponsor Name:FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS UNIVERSITA' CATTOLICA DEL SACRO CUORE
    Full Title: Novel strategies of antithrombotic prophylaxis in patients with Essential Thrombocythemia (ET) at high risk of cardiovascular events: comparison of different dosing regimens of administration of l...
    Medical condition: Essential thrombocytemia
    Disease: Version SOC Term Classification Code Term Level
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10015493 Essential thrombocythaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2004-003955-37 Sponsor Protocol Number: CL3-05590-022 Start Date*: 2005-03-29
    Sponsor Name:INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
    Full Title: Efficacy of perindopril/indapamide combination on coronary Pet Scan parameters. A 6 month, open non controlled stydy in hypertensive patients
    Medical condition: Essential arterial hypertension
    Disease: Version SOC Term Classification Code Term Level
    6.1 10015488 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2009-016738-28 Sponsor Protocol Number: ALISEI Start Date*: 2009-12-11
    Sponsor Name:AZIENDA OSPEDALIERA PISANA
    Full Title: Phase IV prospective, randomized, open with blind endpoints, parallel group study to evaluate the effect of Aliskiren on endothelial dysfunction in patients with essential hypertension
    Medical condition: essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    12.0 10015488 Essential hypertension LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-003659-13 Sponsor Protocol Number: IMG-7289-CTP-201 Start Date*: 2020-06-21
    Sponsor Name:Imago BioSciences Inc.
    Full Title: A Phase 2 Multi-Center, Open Label Study to Assess the Safety,Efficacy and Pharmacodynamics of IMG-7289 in Patients with Essential Thrombocythemia
    Medical condition: Patients with essential thrombocythemia
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10015494 Essential thrombocythemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (GB - no longer in EU/EEA) IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-004938-16 Sponsor Protocol Number: 00-MEP-04 Start Date*: 2008-02-19
    Sponsor Name:Astellas Pharma Europe B.V.
    Full Title: A RANDOMISED, DOUBLE-BLIND STUDY TO COMPARE THE EFFECT ON SYMPATHETIC ACTIVITY AND HEMODYNAMIC PROFILE OF BARNIDIPINE AND AMLODIPINE IN PATIENTS WITH MILD TO MODERATE ESSENTIAL HYPERTENSION.
    Medical condition: Mild to moderate hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-011156-21 Sponsor Protocol Number: CCFM 119/209 Start Date*: 2011-04-28
    Sponsor Name:FONDAZIONE MONZINO CENTRO CARDIOLOGICO
    Full Title: Effects of beta-blockers on exercise performance in uncomplicated hypertension
    Medical condition: Non complicated arterial hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.0 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019524-31 Sponsor Protocol Number: REC15/2375–IT–CL 0332 Start Date*: 2010-06-08
    Sponsor Name:RECORDATI
    Full Title: Safety of an ACE-I/CCB fixed combination (Lercanidipine/Enalapril) in elderly hypertensive patients not adequately controlled by CCB monotherapy
    Medical condition: Essential Hypetension
    Disease: Version SOC Term Classification Code Term Level
    12.1 10015488 Essential hypertension LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-002422-29 Sponsor Protocol Number: 1235.8 Start Date*: 2007-10-19
    Sponsor Name:Boehringer Ingelheim Ltd.
    Full Title: An open-label follow-up trial of the efficacy and safety of chronic administration of the combination of telmisartan 40mg + amlodipine 10mg or the combination of telmisartan 80mg + amlodipine 10mg ...
    Medical condition: essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) GB (Completed) AT (Completed) CZ (Completed) ES (Completed) IT (Completed) BG (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2020-001014-37 Sponsor Protocol Number: ALTUM Start Date*: 2020-08-13
    Sponsor Name:OSPEDALE SAN RAFFAELE
    Full Title: Pharmacogenetics of hypertension: randomized monocentric study in patients with essential hypertension and treated with Spironolactone or Torasemide
    Medical condition: Essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    22.1 10047065 - Vascular disorders 10015489 Essential hypertension, benign LLT
    21.1 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-012784-34 Sponsor Protocol Number: 384/09 Start Date*: 2009-07-08
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: STUDY OF HYDROXYUREA MECHANISMS OF ACTION ON LEUKOCYTE ACTIVATION IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE SYNDROMES.
    Medical condition: MYELOPROLIFERATIVE SYNDROMES
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015493 LLT
    9.1 10036057 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001823-20 Sponsor Protocol Number: CMA-0601-PR-0004 Start Date*: 2006-06-22
    Sponsor Name:CHIESI
    Full Title: A twelve-week, multicentre, double blind, randomised, parallel group, clinical study to assess the antihypertensive efficacy of delapril 15 mg b.i.d. and 30 mg b.i.d. versus lisinopril and placebo
    Medical condition: hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2005-004380-32 Sponsor Protocol Number: 2005-1F Start Date*: 2005-09-15
    Sponsor Name:UNIVERSITA DEGLI STUDI DI PAVIA
    Full Title: RANDOMISED, CONTROLLED STUDY WITH A BLINDED END-POINT TO EVALUATE BY MEANS OF 24-HOUR AMBULATORY BLOOD PRESSURE MONITORING THE ANTIHYPERTENSIVE ACTIVITY OF OLMESARTAN 20 MG IN COMPARISON WITH THA...
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-023606-13 Sponsor Protocol Number: LU01-2010 Start Date*: 2011-02-25
    Sponsor Name:GIENNE PHARMA S.P.A.
    Full Title: Efficacy and safety of Canrenone Add on in patients with Essential Hypertension
    Medical condition: HYPERTENSIVE PATIENTS NON ADEQUATELY CONTROLLED ON THERAPY WITH ACE-I OR ARB + DIURETIC
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000474-42 Sponsor Protocol Number: CL2-90652-002 Start Date*: 2006-12-06
    Sponsor Name:INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
    Full Title: Safety and effects on blood pressure of a daily dose of 0.025 to 0.135 milligram per kilogram of S 90652, a paediatric formulation of perindopril, in hypertensive children having received S 90652 -...
    Medical condition: Arterial Hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-002439-33 Sponsor Protocol Number: MeIn/08/ZOF+HCTZ-HYP/001 Start Date*: 2008-06-26
    Sponsor Name:MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
    Full Title: EFFICACY AND SAFETY OF ZOFENOPRIL + HYDROCHLOROTHIAZIDE COMBINATION VS IRBESARTAN + HYDROCHLOROTHIAZIDE COMBINATION IN ESSENTIAL HYPERTENSIVE PATIENTS NOT CONTROLLED BY PREVIOUS MONOTHERAPY
    Medical condition: Patients with essential hypertension and with at least one additional cardiovascular risk factor, not controlled by a previous monotherapy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) LT (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2004-001252-36 Sponsor Protocol Number: DM/PR/7401/009/03 Start Date*: 2004-11-04
    Sponsor Name:CHIESI
    Full Title: DOUBLE BLIND, RANDOMISED, PARALLEL GROUP, MULTICENTRE STUDY TO EVALUATE THE EFFICACY AND TOLERABILITY OF CHF 1521 (FIXED COMBINATION OF MANIDIPINE AND DELAPRIL) VS LOSARTAN 50 MG AND HYDROCHLOROTHI...
    Medical condition: mild to moderate hypertension in type 2 diabetic patients
    Disease: Version SOC Term Classification Code Term Level
    6.1 10015488 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) DE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2006-001469-41 Sponsor Protocol Number: BA-LO-01 Start Date*: 2006-08-11
    Sponsor Name:ISTITUTO AUXOLOGICO ITALIANO
    Full Title: Randomized, open label, multicenter ABPM study to evaluate the effects of barnidipine as add-on therapy in patients with hypertension not adequately controlled on therapy with losartan
    Medical condition: Arterial hypertension
    Disease: Version SOC Term Classification Code Term Level
    6.1 10015488 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2010-019500-23 Sponsor Protocol Number: MPD-RC111 Start Date*: 2012-02-15
    Sponsor Name:CONSORZIO MARIO NEGRI SUD
    Full Title: Single Arm Salvage Therapy with Pegylated Interferon Alfa-2a for Patients with High Risk Polycythemia Vera or High Risk Essential Thrombocythemia who are Either Hydroxyurea Resistant or Intolerant ...
    Medical condition: High risk polycythemia vera and high risk essential thrombocythemia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10036057 Polycythaemia vera PT
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10015493 Essential thrombocythaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017077-37 Sponsor Protocol Number: BAY98-7106/14725 Start Date*: 2011-03-28
    Sponsor Name:Bayer HealthCare AG
    Full Title: A Multicenter, Multifactorial, Randomized, Double-Blind, Placebo-Controlled Dose- Finding Study of Nifedipine GITS and Candesartan in Combination Compared to Monotherapy in Adult Patients with Esse...
    Medical condition: To determine the dose-response of the various combinations of nifedipine GITS (gastrointestinal therapeutic system) and candesartan as compared to monotherapy and placebo based on the blood pressur...
    Disease: Version SOC Term Classification Code Term Level
    13.1 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed) LT (Completed) IT (Completed) ES (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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