- Trials with a EudraCT protocol (10)
- Paediatric studies in scope of Art45 of the Paediatric Regulation (0)
10 result(s) found for: Leber's hereditary optic neuropathy.
Displaying page 1 of 1.
EudraCT Number: 2011-001034-42 | Sponsor Protocol Number: SNT-II-003-OFU | Start Date*: 2011-08-25 | |||||||||||
Sponsor Name:Santhera Pharmaceuticals (Switzerland) Limited | |||||||||||||
Full Title: A single visit, observational, follow-up study of Patients with Leber’s Hereditary Optic Neuropathy following participation in SNT-II-003 trial | |||||||||||||
Medical condition: Leber’s Hereditary Optic Neuropathy | |||||||||||||
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Population Age: Adolescents, Under 18, Adults | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2013-001405-90 | Sponsor Protocol Number: GS-LHON/CLIN/01 | Start Date*: 2013-12-26 | |||||||||||
Sponsor Name:GENSIGHT-BIOLOGICS | |||||||||||||
Full Title: A phase I/IIa, non randomized, escalating dose, open-label study to evaluate safety and efficacy of GS010 (rAAV2/2-ND4) in patients suffering from Leber Hereditary Optic Neuropathy due to mutations... | |||||||||||||
Medical condition: Leber Hereditary Optic Neuropathy due to mutations in the mitochondrial NADH Dehydrogenase 4 gene | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: FR (Completed) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2017-002187-40 | Sponsor Protocol Number: GS-LHON-CLIN-05 | Start Date*: 2018-03-15 |
Sponsor Name:GENSIGHT BIOLOGICS | ||
Full Title: Efficacy and Safety of Bilateral Intravitreal Injection of GS010: A Randomized, Double-Masked, Placebo-Controlled Trial in Subjects Affected with G11778A ND4 Leber Hereditary Optic Neuropathy for U... | ||
Medical condition: Leber Hereditary Optic Neuropathy due to mutations in the mitochondrial NADH Dehydrogenase 4 gene | ||
Disease: | ||
Population Age: Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: BE (Completed) FR (Completed) GB (GB - no longer in EU/EEA) ES (Ongoing) NL (Ongoing) IT (Completed) | ||
Trial results: (No results available) |
EudraCT Number: 2017-002153-11 | Sponsor Protocol Number: GS-LHON-CLIN-06 | Start Date*: 2018-02-12 | |||||||||||
Sponsor Name:GENSIGHT BIOLOGICS | |||||||||||||
Full Title: Long-term Follow-up of ND4 LHON Subjects Treated With GS010 Ocular Gene Therapy in the RESCUE or REVERSE Phase III Clinical Trials | |||||||||||||
Medical condition: Leber Hereditary Optic Neuropathy due to mutations in the mitochondrial NADH Dehydrogenase 4 gene | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Completed) GB (GB - no longer in EU/EEA) IT (Completed) FR (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2015-004405-16 | Sponsor Protocol Number: SNT-IV-005 | Start Date*: 2016-03-16 | |||||||||||
Sponsor Name:Santhera Pharmaceuticals (Switzerland) Limited | |||||||||||||
Full Title: External Natural History Controlled, open-Label Intervention Study to Assess the Efficacy and Safety of Long-Term Treatment with Raxone® in Leber’s Hereditary Optic Neuropathy (LHON) | |||||||||||||
Medical condition: Leber’s Hereditary Optic Neuropathy / LHON is a maternally inherited loss of vision due to atrophy of the optic nerve. It typically presents in young adults, mostly men, as painless acute or subacu... | |||||||||||||
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Population Age: Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: AT (Completed) DE (Completed) BE (Completed) PT (Completed) ES (Completed) BG (Completed) PL (Completed) IT (Completed) | |||||||||||||
Trial results: View results |
EudraCT Number: 2006-002679-42 | Sponsor Protocol Number: SNT-II-003 | Start Date*: 2006-11-22 |
Sponsor Name:Santhera Pharmaceuticals (Switzerland) Limited | ||
Full Title: A double blind, randomised, placebo-controlled study of the efficacy, safety and tolerability of idebenone in the treatment of patients with Leber's Hereditary Optic Neuropathy | ||
Medical condition: Leber's Hereditary Optic Neuropathy | ||
Disease: | ||
Population Age: Adolescents, Under 18, Adults | Gender: Male, Female | |
Trial protocol: GB (Completed) DE (Completed) | ||
Trial results: View results |
EudraCT Number: 2009-016982-26 | Sponsor Protocol Number: ST200-ODU-09-01 | Start Date*: 2010-11-04 | |||||||||||
Sponsor Name:SIGMA-TAU | |||||||||||||
Full Title: Neuronal conduction along the visual patways after oral treatment with Acetyl-L-carnitine in patients with Leber’s Hereditary Optic Neuropathy | |||||||||||||
Medical condition: Leber’s Hereditary Optic Neuropathy | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: IT (Completed) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2015-001265-11 | Sponsor Protocol Number: GS-LHON-CLIN-03A | Start Date*: 2016-01-21 |
Sponsor Name:GENSIGHT-BIOLOGICS | ||
Full Title: A Randomized, Double-Masked, Sham-Controlled, Pivotal Clinical Trial to Evaluate the Efficacy of a Single Intravitreal Injection of GS010 (rAAV2/2-ND4) in Subjects Affected for 6 Months or Less by... | ||
Medical condition: Leber Hereditary Optic Neuropathy due to mutations in the mitochondrial NADH Dehydrogenase 4 gene | ||
Disease: | ||
Population Age: Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: DE (Completed) GB (Completed) IT (Completed) | ||
Trial results: View results |
EudraCT Number: 2015-001266-26 | Sponsor Protocol Number: GS-LHON-CLIN-03B | Start Date*: 2016-01-21 |
Sponsor Name:GENSIGHT-BIOLOGICS | ||
Full Title: A Randomized, Double-Masked, Sham-Controlled, Pivotal Clinical Trial to Evaluate the Efficacy of a Single Intravitreal Injection of GS010 (rAAV2/2-ND4) in Subjects Affected for more than 6 months a... | ||
Medical condition: Leber Hereditary Optic Neuropathy due to mutations in the mitochondrial NADH Dehydrogenase 4 gene | ||
Disease: | ||
Population Age: Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: DE (Completed) GB (Completed) IT (Completed) | ||
Trial results: View results |
EudraCT Number: 2011-004157-66 | Sponsor Protocol Number: QRK202 | Start Date*: 2012-05-29 | |||||||||||
Sponsor Name:Quark Pharmaceuticals, Inc. | |||||||||||||
Full Title: An Open-Label Dose Escalation Study of PF-04523655 (Stratum I) Combined With A Prospective, Randomized, Double-Masked, Multi-Center, Controlled Study (Stratum II) Evaluating The Efficacy and Safety... | |||||||||||||
Medical condition: Diabetic Macular Edema | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Completed) CZ (Completed) BE (Completed) GB (Completed) | |||||||||||||
Trial results: (No results available) |
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