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Clinical trials for Limbal stem cell

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    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    9 result(s) found for: Limbal stem cell. Displaying page 1 of 1.
    EudraCT Number: 2008-001543-19 Sponsor Protocol Number: CSCTversion1.2 Start Date*: Information not available in EudraCT
    Sponsor Name:Antwerp University Hospital (UZA)
    Full Title: Cultivated Limbal Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency.
    Medical condition: Patients suffering from Limbal Stem Cell Deficiency will be investigated during the course of this clinical trial.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000608-16 Sponsor Protocol Number: 5466 Start Date*: 2011-12-21
    Sponsor Name:The Newcastle upon Tyne Hospitals NHS Foundation Trust [...]
    1. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    2. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: To evaluate the safety and effectiveness of human ex vivo expanded autologous limbal stem cells for the treatment of unilateral total limbal stem cell deficiency
    Medical condition: unilateral total limbal stem cell deficiency
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-024409-11 Sponsor Protocol Number: LSC-001 Start Date*: 2011-08-11
    Sponsor Name:Scottish National Blood Transfusion Service [...]
    1. Scottish National Blood Transfusion Service
    2. NHS Lothian
    Full Title: Pilot Clinical Assessment of Ex Vivo Expanded Corneal Limbal Stem Cell Transplantation in Patients with Severe Ocular Surface Disease (OSD) Arising from Limbal Stem Cell Deficiency
    Medical condition: Severe Ocular Surface Disease (OSD)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10067103 Ocular surface disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-004247-24 Sponsor Protocol Number: CCRG13-003 Start Date*: 2015-01-27
    Sponsor Name:Antwerp University Hospital (UZA)
    Full Title: Translational stem cell research in ophthalmology - regenerating the anterior cornea through standardized transplantation of limbal epithelial stem cells: a phase II multicenter trial
    Medical condition: Primary and secondary Limbal Stem Cell Deficiencies
    Disease: Version SOC Term Classification Code Term Level
    17.1 10042613 - Surgical and medical procedures 10069798 Amniotic membrane graft PT
    17.1 10015919 - Eye disorders 10072138 Limbal stem cell deficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001790-16 Sponsor Protocol Number: LSC2-II-01 Start Date*: 2019-01-07
    Sponsor Name:RHEACELL GmbH & Co. KG
    Full Title: AN INTERVENTIONAL, OPEN-LABEL, MULTICENTER PHASE I/IIA CLINICAL TRIAL TO INVESTIGATE THE SAFETY AND EFFICACY OF ASCENDING DOSES OF ALLOGENEIC ABCB5-POSITIVE LIMBAL STEM CELLS (LSC2) FOR THE TREATME...
    Medical condition: Limbal stem cell deficiency (LSCD)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10015919 - Eye disorders 10072138 Limbal stem cell deficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-003215-63 Sponsor Protocol Number: 69HCL19_0032 Start Date*: 2020-03-10
    Sponsor Name:Hospices Civils de Lyon - Direction de la Recherche Clinique et de l'Innovation
    Full Title: Cultured Autologous Oral Mucosa Epithelial sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency - FEMJA for « Feuillet Epithélial de Muqueuse Jugale Autologue »
    Medical condition: Bilateral Limbal Stem Cell Deficiency
    Disease: Version SOC Term Classification Code Term Level
    20.1 10015919 - Eye disorders 10072138 Limbal stem cell deficiency PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-001344-11 Sponsor Protocol Number: CCD-GPLSCD01-03-FU Start Date*: 2018-04-11
    Sponsor Name:Chiesi Farmaceutici S.p.A.
    Full Title: Multinational, multicenter, prospective, long-term safety and efficacy follow-up study after Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for restoration of corneal epithelium i...
    Medical condition: corneal lesions with associated moderate to severe limbal stem cell deficiency due to ocular burns
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10011012 Corneal epithelium opacity LLT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) PL (Completed) FR (Completed) DE (Completed) GB (GB - no longer in EU/EEA) ES (Ongoing) NL (Ongoing) IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-000598-30 Sponsor Protocol Number: CS001-EU01 Start Date*: 2012-03-06
    Sponsor Name:Cellseed France S.A.R.L.
    Full Title: MULTICENTER STUDY OF CULTURED AUTOLOGOUS ORAL MUCOSAL EPITHELIAL CELL-SHEET (CAOMECS) TRANSPLANTATION TO PATIENTS WITH TOTAL LIMBAL STEM CELL DEFICIENCY
    Medical condition: Limbal Stem Cell Deficiency of the Eye
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10063581 Stem cell transplant PT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Ongoing) AT (Prematurely Ended) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002845-23 Sponsor Protocol Number: CCD-GPLSCD01-03 Start Date*: 2015-12-16
    Sponsor Name:Holostem Terapie Avanzate s.r.l.
    Full Title: Multinational, multicentre, prospective, open-label, uncontrolled clinical trial to assess the efficacy and safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for restoratio...
    Medical condition: corneal lesions with associated moderate to severe limbal stem cell deficiency due to ocular burns
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10011012 Corneal epithelium opacity LLT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (GB - no longer in EU/EEA) BE (Completed) NL (Ongoing) FR (Completed) PL (Completed) ES (Ongoing) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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