- Trials with a EudraCT protocol (7)
- Paediatric studies in scope of Art45 of the Paediatric Regulation (0)
7 result(s) found for: Melanocortin.
Displaying page 1 of 1.
| EudraCT Number: 2017-005006-35 | Sponsor Protocol Number: RM-493-022 | Start Date*: 2018-05-30 |
| Sponsor Name:Rhythm Pharmaceuticals, Inc. | ||
| Full Title: Long Term Extension Trial of setmelanotide (RM-493) for patients who have completed a trial of Setmelanotide for the treatment of obesity associated with genetic defects upstream of the MC4 recepto... | ||
| Medical condition: Patients with obesity caused by genetic defects upstream of the MC4 receptor in the leptin-melanocortin pathway. Human Genetics studies have identified several diseases that are the result of genet... | ||
| Disease: | ||
| Population Age: Children, Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
| Trial protocol: DE (Ongoing) FR (Ongoing) NL (Ongoing) GB (GB - no longer in EU/EEA) BE (Ongoing) ES (Ongoing) GR (Ongoing) | ||
| Trial results: (No results available) | ||
| EudraCT Number: 2016-002320-83 | Sponsor Protocol Number: RM-493-012 | Start Date*: 2016-09-28 |
| Sponsor Name:Rhythm Pharmaceuticals, Inc. | ||
| Full Title: An Open Label, 1-Year Trial, including a Double-Blind Placebo-Controlled Withdrawal Period, of Setmelanotide (RM-493), a Melanocortin 4 Receptor (MC4R) Agonist, in Early Onset POMC Deficiency Obesi... | ||
| Medical condition: Early onset pro-opiomelanocortin deficiency obesity | ||
| Disease: | ||
| Population Age: Children, Adolescents, Under 18, Adults | Gender: Male, Female | |
| Trial protocol: DE (Completed) GB (Completed) FR (Completed) BE (Completed) ES (Completed) | ||
| Trial results: View results | ||
| EudraCT Number: 2017-002005-36 | Sponsor Protocol Number: RM-493-015 | Start Date*: 2017-10-30 |
| Sponsor Name:Rhythm Pharmaceuticals, Inc. | ||
| Full Title: An Open Label, 1-Year Trial, including a Double-Blind Placebo-Controlled Withdrawal Period, of Setmelanotide (RM-493), a Melanocortin 4 Receptor (MC4R) Agonist, in Leptin Receptor (LEPR) Deficiency... | ||
| Medical condition: Early Onset Leptin Receptor (LEPR) Deficiency Obesity due to Bi-Allelic Loss-of-Function LEPR Genetic Mutation | ||
| Disease: | ||
| Population Age: Children, Adolescents, Under 18, Adults | Gender: Male, Female | |
| Trial protocol: DE (Completed) FR (Completed) NL (Completed) GB (Completed) | ||
| Trial results: View results | ||
| EudraCT Number: 2008-006968-11 | Sponsor Protocol Number: AP214-CS005 | Start Date*: 2009-04-21 | |||||||||||
| Sponsor Name:Action Pharma A/S | |||||||||||||
| Full Title: Pharmacokinectics of AP214 Acetate in patients undergoing cardiac surgery. A randomized, double-blind, placebo-controlled sequential ascending dose trial investigating pharmacokinetics, as well as... | |||||||||||||
| Medical condition: Action Pharma A/S is developing AP214 Acetate for the prevention of postsurgical kidney injury after thoracic aortic aneurysm repair surgery. In phase 2: Patients undergoing cardiac surgery, defin... | |||||||||||||
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| Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
| Trial protocol: DK (Completed) | |||||||||||||
| Trial results: (No results available) | |||||||||||||
| EudraCT Number: 2010-022630-92 | Sponsor Protocol Number: AP214-CS007 | Start Date*: 2010-11-05 | |||||||||||
| Sponsor Name:Action Pharma A/S | |||||||||||||
| Full Title: An Explorative Phase 2, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Trial of two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Su... | |||||||||||||
| Medical condition: Action Pharma is developing AP214 Acetate for the prevention of postsurgical kidney injury after cardiac surgery. Trial population is patients with increased risk for development of Kidney Inju... | |||||||||||||
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| Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
| Trial protocol: DK (Completed) | |||||||||||||
| Trial results: (No results available) | |||||||||||||
| EudraCT Number: 2014-002392-28 | Sponsor Protocol Number: RM-493-Supplementation-Therapy | Start Date*: 2014-11-28 |
| Sponsor Name:Charité Univeritaetsmedizin Berlin | ||
| Full Title: Setmelanotide (RM-493) Treatment Trial in Patients with rare genetic disorders of obesity | ||
| Medical condition: Body weight is regulated within the hypothalamus. In rare cases mutations in genes, which are embedded in the signaling cascades of the hypothalamus lead to early onset severe obesity. POMC is one ... | ||
| Disease: | ||
| Population Age: Adolescents, Under 18, Adults | Gender: Male, Female | |
| Trial protocol: DE (Completed) | ||
| Trial results: View results | ||
| EudraCT Number: 2021-004597-65 | Sponsor Protocol Number: RM-493-037 | Start Date*: 2022-10-20 | |||||||||||||||||||||
| Sponsor Name:Rhythm Pharmaceuticals, Inc. | |||||||||||||||||||||||
| Full Title: A Phase 3, Randomized, Double-Blind Trial of Two Formulations of Setmelanotide (Daily and Weekly) with a Crossover to Open-Label Once Weekly Setmelanotide in Patients with Specific Gene Defects in ... | |||||||||||||||||||||||
| Medical condition: Treatment of obesity associated with genetic defects upstream of the MC4 receptor in the leptin-melanocortin pathway. Diseases that are the result of genetic defects affecting the MC4R pathway, con... | |||||||||||||||||||||||
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| Population Age: Children, Adolescents, Under 18, Adults | Gender: Male, Female | ||||||||||||||||||||||
| Trial protocol: NL (Completed) DE (Completed) | |||||||||||||||||||||||
| Trial results: (No results available) | |||||||||||||||||||||||
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