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Clinical trials for Osteonecrosis

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    42 result(s) found for: Osteonecrosis. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2006-001286-42 Sponsor Protocol Number: ABI 55-0603-1 Start Date*: 2006-09-20
    Sponsor Name:Aastrom Biosciences, Inc
    Full Title: Multi-center, Multi-national Clinical Trial of the Application of Tissue Repair Cell (TRC) Therapy of Osteonecrosis in the Femur Head
    Medical condition: Osteonecrosis of the femur head
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012929-11 Sponsor Protocol Number: PREOB-ON3 Start Date*: 2011-10-17
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: Phase III, pivotal, multicentre, randomised, double-blind controlled Study to evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Os...
    Medical condition: Osteonecrosis of the Femoral Head
    Disease: Version SOC Term Classification Code Term Level
    18.1 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) DE (Completed) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-000887-32 Sponsor Protocol Number: ORN-02 Start Date*: 2015-07-20
    Sponsor Name:Västra Götalandsregionen/NÄL
    Full Title: Prophylactic treatment of osteoradionecrosis (ORN) with pentoxifylline and α-tocopherol (PENTO)
    Medical condition: Osteoradionecrosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    18.0 10022117 - Injury, poisoning and procedural complications 10067352 Osteoradionecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007842-36 Sponsor Protocol Number: DAHANCA-21 Start Date*: 2008-05-05
    Sponsor Name:Lone Elisabeth Forner
    Full Title: Hyperbaric oxygen treatment of mandibular osteoradionecrosis. A randomized clinical trial.
    Medical condition: Mandibular osteoradionecrosis occuring from radiation treatment of cancer. No healthy volunteers
    Disease: Version SOC Term Classification Code Term Level
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10064658 Osteonecrosis of jaw PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) SE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-000886-35 Sponsor Protocol Number: AloFem Start Date*: 2018-06-27
    Sponsor Name:Enrique Gomez-Barrena
    Full Title: Evaluation of safety, feasibility and preliminary efficacy of MSCs from third party donors in the treatment of patients with osteonecrosis of the femoral head after allogeneic Stem Cell Transplanta...
    Medical condition: Osteonecrosis of the Femoral Head
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10003860 Avascular necrosis femoral head LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-022318-22 Sponsor Protocol Number: tutkijalähtöinen tutkimus, Start Date*: 2010-10-20
    Sponsor Name:Maarit Valkealahti / University hospital of Oulu
    Full Title: Tsoledronaatti hoito paikallista kiihtynyttä luunvaihdunta- oireyhtymää sairastavilla potilailla
    Medical condition: Tässä tutkimuksessa esitetään bisfosfonaatti –lääkkeen käyttöä uusissa indikaatioissa. Haemme tällä tutkimussuunnitelmalla lupaa kliiniseen tutkimukseen, jossa selvitetään, mikä on lääkkeen teho h...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10031264 Osteonecrosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-000618-23 Sponsor Protocol Number: ORN-01 Start Date*: 2015-05-05
    Sponsor Name:Västra Götalandsregionen/NÄL
    Full Title: Treatment of osteoradionecrosis (ORN) with pentoxifylline and α-tocopherol (PENTO)
    Medical condition: Osteoradionecrosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031264 Osteonecrosis PT
    18.0 10022117 - Injury, poisoning and procedural complications 10067352 Osteoradionecrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-019060-37 Sponsor Protocol Number: CH.MAX-FACC.02/2009 Start Date*: 2010-07-09
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: Clinical prospective study to evaluate the efficacy of hygienical therapy and metronidazole in addition to antibiotic therapy in patients affected by bisphosponate-associated osteonecrosis of the jaws
    Medical condition: patients affected by bisphosponate-associated osteonecrosis of the jaws and infection.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031264 LLT
    9.1 10021864 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-005258-70 Sponsor Protocol Number: CSM/ON/2011 Start Date*: 2012-06-04
    Sponsor Name:Fundación Universidad de Salamanca
    Full Title: Ensayo clínico fase I/II prospectivo, abierto, no aleatorizado de tratamiento de la osteonecrosis de la cabeza femoral mediante la administración de células mesenquimales autólogas.
    Medical condition: Pacientes con ostenecrosis de la cabeza femoral en estadios precoces, estadios inferiores a IIIC de la clasificación de ARCO.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-002669-13 Sponsor Protocol Number: 87RI21_0052 Start Date*: 2022-11-25
    Sponsor Name:Limoges University Hospital
    Full Title: The PENTO protocol in Medication-related osteonecrosis of the jaw (MRONJ): a single-center phase IIa trial
    Medical condition: Medication-related osteonecrosis of the jaw (MRONJ)
    Disease: Version SOC Term Classification Code Term Level
    23.1 100000004859 10084881 Medication-related osteonecrosis of jaw LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-006225-27 Sponsor Protocol Number: SP000283 Start Date*: 2008-12-15
    Sponsor Name:The University of Liverpool [...]
    1. The University of Liverpool
    2. Aintree University Hospital NHS Trust
    Full Title: Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible (HOPON)
    Medical condition: Osteoradionecrosis (ORN) of the irradiated mandible; the most feared complication of radiotherapy for head and neck cancer.
    Disease: Version SOC Term Classification Code Term Level
    19.1 10028395 - Musculoskeletal and connective tissue disorders 10064658 Osteonecrosis of jaw PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-003721-22 Sponsor Protocol Number: A4091058 Start Date*: 2016-01-14
    Sponsor Name:Pfizer Inc, 235 East 42nd Street, New York, NY 10017
    Full Title: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROLLED, MULTICENTER STUDY OF THE LONG-TERM SAFETY AND EFFICACY OF SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP ...
    Medical condition: Osteoarthritis of the hip or knee
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) SK (Completed) LT (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2018-002096-17 Sponsor Protocol Number: EORTC-1762-STBSG Start Date*: 2020-04-21
    Sponsor Name:European Organisation for Research and Treatment of Cancer (EORTC)
    Full Title: Reduced dose-density of denosumab for maintenance therapy of unresectable giant cell tumor of bone: a multicenter phase II study "REDUCE"
    Medical condition: Giant cell tumor of bone
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10005968 Bone giant cell tumor LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed) GB (GB - no longer in EU/EEA) DK (Completed) ES (Prematurely Ended) IT (Completed)
    Trial results: View results
    EudraCT Number: 2019-001492-37 Sponsor Protocol Number: Z-AMD Start Date*: 2019-11-01
    Sponsor Name:Oslo University Hospital
    Full Title: Zoledronic acid as adjuvant therapy in neovascular Age-related Macular Degeneration (The Z-AMD study): a randomized controlled pilot study
    Medical condition: Neovascular Age-related Macular Degeneration
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10071129 Neovascular age-related macular degeneration PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002550-39 Sponsor Protocol Number: PDY13949 Start Date*: 2016-10-20
    Sponsor Name:Genzyme Corporation
    Full Title: 4-part, open-label, multicenter, multinational study of the safety, tolerability, pharmacokinetics, pharmacodynamic, and exploratory efficacy of venglustat in combination with Cerezyme in adult pat...
    Medical condition: Gaucher disease
    Disease: Version SOC Term Classification Code Term Level
    24.1 10010331 - Congenital, familial and genetic disorders 10075699 Gaucher's disease type III PT
    24.1 10010331 - Congenital, familial and genetic disorders 10075697 Gaucher's disease type I PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2012-002010-39 Sponsor Protocol Number: ORTHO-2 Start Date*: 2014-04-11
    Sponsor Name:Universidad Autónoma de Madrid
    Full Title: Evaluation of safety and feasibility of bone marrow derived autologous MSCs to enhance bone healing in patients with avascular necrosis of femoral head
    Medical condition: Early avascular necrosis of the femoral head (MRI diagnosis): Ficat and Arlet 0, 1, or 2 (Steinberg stages 0, I, IIA, IIB, or IIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10003860 Avascular necrosis femoral head LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) IT (Ongoing) ES (Ongoing) RO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-024162-22 Sponsor Protocol Number: ACTLP001-01 Start Date*: 2012-05-02
    Sponsor Name:Azellon Ltd
    Full Title: A Prospective Open-Label Study to Evaluate the Safety of Cell Bandage (Mesenchymal Stem Cells) in the Treatment of Meniscal Tears
    Medical condition: Meniscal tear that would otherwise be treated by a partial meniscectomy.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2016-002678-11 Sponsor Protocol Number: ICO-13-001 Start Date*: 2018-06-07
    Sponsor Name:Institut Català d’Oncologia
    Full Title: An open label biomarker pilot study of the antitumoral acrivity of denosumab in the pre-operative setting of early breast cancer
    Medical condition: early breast cancer
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2018-001215-69 Sponsor Protocol Number: 69HCL17_0020 Start Date*: 2018-09-24
    Sponsor Name:Hospices Civils de Lyon
    Full Title: MAINEPSAN Study A Prospective Comparative Randomized Double-blind Placebo-controlled In-Parallel Groups Multicenter, Study to Evaluate the remission MAINtenance using Extended administration of ...
    Medical condition: Patients with newly diagnosed or relapsing granulomatosis with polyangiitis (GPA, Wegener’s) or microscopic polyangiitis (MPA) , 12 months after initiation of treatment for vasculitis onset or flar...
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021428 - Immune system disorders 10050894 Anti-neutrophil cytoplasmic antibody positive vasculitis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-004266-18 Sponsor Protocol Number: LTF-307 Start Date*: 2020-09-03
    Sponsor Name:bluebird bio, Inc.
    Full Title: Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral Vector
    Medical condition: Subjects with sickle-cell disease treated with gene therapy drug products in a bluebird bio-sponsored study will be invited to participate in this long-term follow-up study to monitor the safety an...
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004850 10040648 Sickle cell SC disease LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
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