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Clinical trials for Pathophysiology

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44363   clinical trials with a EudraCT protocol, of which   7387   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    85 result(s) found for: Pathophysiology. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2011-000626-29 Sponsor Protocol Number: KS001 Start Date*: 2011-12-13
    Sponsor Name:QUEEN MARY UNIVERSITY OF LONDON
    Full Title: Keloid Scars: A randomised clinical and laboratory based study on the treatment and differentiation factors of the local disease
    Medical condition: Keloid scarring
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003617-33 Sponsor Protocol Number: 03-2005 Start Date*: Information not available in EudraCT
    Sponsor Name:Charité
    Full Title: A Randomised Cross-Over Study to Explore the Pathophysiological Mechanisms Involved in the Treatment of Actinic Keratoses with Solaraze
    Medical condition: actinic keratosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2014-001384-12 Sponsor Protocol Number: PancolonicPressurization Start Date*: 2014-07-16
    Sponsor Name:KULEUVEN
    Full Title: IS THE ABSENCE OF PAN-COLONIC PRESSURIZATIONS A RELEVANT PATHOPHYSIOLOGICAL MECHANISM IN A SUBGROUP OF PATIENTS WITH CHRONIC IDIOPHATIC CONSTIPATION?
    Medical condition: COLONIC MOTILITY WILL BE STUDIED BOTH IN HEALTHY SUBJECTS AND IN PATIENTS WITH CHRONIC CONSTIPATION
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-003022-89 Sponsor Protocol Number: 1.1 Start Date*: 2019-10-18
    Sponsor Name:HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS
    Full Title: GUT-DERIVED INCRETIN HORMONES IN THE PATHOPHYSIOLOGY OF TYPE 1 DIABETES MELLITUS; EFFECT OF METFORMIN TREATMENT (THE INCREDIBLE-ME TRIAL)
    Medical condition: GUT-DERIVED INCRETIN HORMONES IN THE PATHOPHYSIOLOGY OF TYPE 1 DIABETES MELLITUS; EFFECT OF METFORMIN TREATMENT
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10012601 Diabetes mellitus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000197-35 Sponsor Protocol Number: IR-HP-14-01 Start Date*: 2015-06-09
    Sponsor Name:AOU DI BOLOGNA POLICLINICO S.ORSOLA-MALPIGHI
    Full Title: insulin resistance, obesity and gastrointestinal bacteria
    Medical condition: Helicobacter pylori infection
    Disease: Version SOC Term Classification Code Term Level
    18.1 10027433 - Metabolism and nutrition disorders 10022489 Insulin resistance PT
    18.1 100000004862 10004028 Bacterial infection due to helicobacter pylori (H. pylori) LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2020-004115-27 Sponsor Protocol Number: IIBSP-OXI-2020-102 Start Date*: 2021-05-10
    Sponsor Name:Institut de Recerca Hospital de la Santa Creu i Sant Pau - IIB Sant Pau
    Full Title: Identification and clinical relevance of oxytocin deficient status: randomized, crossover, placebo-controlled pathophysiological pilot study: GLP1 study
    Medical condition: Hypopituitarism
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-000396-20 Sponsor Protocol Number: Dropizol_2020 Start Date*: 2021-01-02
    Sponsor Name:Mech-Sense, Aalborg University Hospital
    Full Title: Opium tincture against chronic diarrhea - Patients: An investigator initiated, randomized placebo-controlled, clinical trial
    Medical condition: Chronic diarrhea
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10066556 Chronic diarrhea LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-003116-22 Sponsor Protocol Number: RBK091 Start Date*: 2006-12-21
    Sponsor Name:Prof. Sechtem, Department of Cardiology, Robert Bosch Hospital
    Full Title: Application of Sildenafil in patients with documented coronary vasospasm in order to explore the pathophysiology of coronary vasospasm and the therapeutic effects of Sildenafil in patients sufferin...
    Medical condition: Coronary vasospasm is an abrupt severe vasoconstriction of coronary arteries leading to myocardial ischemia and angina pectoris. The reason for the occurrence of coronary spasm and the cellular mec...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019891-54 Sponsor Protocol Number: WC2010-022 Start Date*: 2010-08-10
    Sponsor Name:VU University Medical Center
    Full Title: Effects of oral corticosteroids and DMSO on inflammatory signs and symptoms in Complex Regional Pain Syndrome type 1
    Medical condition: Complex regional pain syndrome type 1. This condition is a pain syndrome with unknown pathophysiology. Research shows that inflammation plays a role in the development and course of the disease. Ev...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-004629-18 Sponsor Protocol Number: helmich-veni-2019 Start Date*: 2017-04-13
    Sponsor Name:Radboud University Nijmegen
    Full Title: The noradrenergic basis of Parkinson’s tremor: a systems-level fMRI approach
    Medical condition: Tremor in Parkinson's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-000746-32 Sponsor Protocol Number: 5-HT_CFM Start Date*: 2008-04-23
    Sponsor Name:Karolinska Institutet
    Full Title: Validation of experimental pain models as translational for craniofacial myalgia with respect to the influence of 5-HT, glutamate, cortisol and estradiol level
    Medical condition: Patients with craniomandibular myalgia (CM), i.e. with pain in the masster muscle and a diagnosis of myofascial pain according to the RDC/TMD criteria, and healthy subjects of both sexes, over 18 y...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-016924-30 Sponsor Protocol Number: NorCAPITAL Start Date*: Information not available in EudraCT
    Sponsor Name:Division of Paediatrics, Rikshospitalet University Hospital
    Full Title: NorCAPITAL The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial
    Medical condition: Chronic fatigue syndrom/myalgic encephalomyelitis (CFS/ME) in adolescents
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002567-24 Sponsor Protocol Number: M120204-063 Start Date*: 2005-04-04
    Sponsor Name:Millennium Pharmaceuticals, Inc.
    Full Title: A Phase 2a Magnetic Resonance Imaging Study of the Safety and Efficacy of MLN1202 in patients with Multiple Sclerosis
    Medical condition: The purpose of this study is to investigate the safety, PK parameters, PD responses, and clinical responses of multiple dose administration of MLN1202 in patients with relapsing remitting multiple ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) GB (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2016-001176-30 Sponsor Protocol Number: 20167169 Start Date*: 2016-06-15
    Sponsor Name:Clinical Research Institute, HUCH Ltd.
    Full Title: Effects of PCSK9 inhibition by Evolocumab on postprandial lipid metabolism in type 2 diabetes
    Medical condition: type 2 diabetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2016-001611-20 Sponsor Protocol Number: 357-0-0 Start Date*: 2018-07-24
    Sponsor Name:University of Tübingen
    Full Title: Pathophysiology-based therapy of epileptic encephalopathies
    Medical condition: patients with epileptic encephalopathies
    Disease:
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-002007-97 Sponsor Protocol Number: 2017/24JUL/374 Start Date*: 2017-12-07
    Sponsor Name:Cliniques universitaires Saint-Luc
    Full Title: Does LOW Dose DEXmedetomidine After Cardiopulmonary Bypass Separation Decrease the Incidence of DELirium: A Double-blind Randomized Placebocontrolled Study (LOWDEXDEL Study)
    Medical condition: To find if Dexmedetomidine in cardiac surgery would have any neuroprotective effects by stimulating the alpha 2A-receptors and as such would decrease the incidence of postoperative delirium.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-002634-20 Sponsor Protocol Number: NBF_HK_01_2018 Start Date*: 2018-10-23
    Sponsor Name:Anaesthesia Department, Hvidovre Hospital, Capital Region of Denmark
    Full Title: Highdose steroid for total knee arthroplasty - A randomized doubleblindet controlled trial.
    Medical condition: Perioperative management of total knee-arthroplasty because of knee-osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10023469 Knee arthroplasty PT
    20.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2018-002636-25 Sponsor Protocol Number: NBF_HK_03_2018 Start Date*: 2018-10-23
    Sponsor Name:Anaesthesia Department, Hvidovre Hospital, Capital Region of Denmark.
    Full Title: Highdose Steroid for High Pain Responders undergoing Total Hip-arthroplasty - A randomized doubleblindet controlled trial.
    Medical condition: Perioperative management of total hip-arthroplasty because of hip-osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10020096 Hip arthroplasty PT
    20.1 100000004863 10054711 Postoperative pain LLT
    20.1 100000004867 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-002970-36 Sponsor Protocol Number: 54508 Start Date*: 2016-06-06
    Sponsor Name:Maastricht University Medical Center
    Full Title: Human intestinal ischemia and reperfusion
    Medical condition: The participants enrolled in this study will all undergo major upper abdominal surgery (i.e. mostly Pylorus Preserving Pancreatico Duodenectomy or whipple procedure) mostly for pancreatic cancer, p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-003395-23 Sponsor Protocol Number: HK_VL_08_2014 Start Date*: 2015-01-20
    Sponsor Name:Section for Surgical Pathophysiology, Rigshospitalet
    Full Title: Effect of preoperative intravenous highdose methylprednisolone on quadriceps muscle function, endothelial function, complement activation and glucose homeostasis in patients scheduled for total kne...
    Medical condition: Knee joint arthrosis
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10003416 Arthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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