Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Premalignant

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    25 result(s) found for: Premalignant. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2020-000295-38 Sponsor Protocol Number: IMPEDE Start Date*: 2020-05-27
    Sponsor Name:AZIENDA SOCIO SANITARIA TERRITORIALE DEGLI SPEDALI CIVILI DI BRESCIA
    Full Title: Phase II trial, open label, single-arm, of Immune Checkpoint Inhibitor In High Risk Oral Premalignant Lesions
    Medical condition: Clinical and histological evidence of Oral Premalignant Lesions (OPL) with high risk of malignant transformation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022891 - Investigations 10078906 Oral soft tissue biopsy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003134-13 Sponsor Protocol Number: A551109 Start Date*: 2012-02-13
    Sponsor Name:Erasmus MC
    Full Title: 5-Aminolevulinic Acid PhotoDynamic Therapy for the treatment of premalignant disorders of the vulva.
    Medical condition: Premalignant vulvar disorders (usual type Vulvar Intraepithelial Neoplasia)
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10062135 Vulval neoplasm PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001260-34 Sponsor Protocol Number: 414520 Start Date*: 2014-09-09
    Sponsor Name:Maastricht University Medical Center
    Full Title: TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): a randomized controlled trial
    Medical condition: High grade cervical intraepithelial neoplasia.
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-000265-32 Sponsor Protocol Number: Q282dnro3/2015 Start Date*: 2015-04-08
    Sponsor Name:Janne Räsänen
    Full Title: Daylight photodynamic therapy for actinic keratoses: a multicentre study comparing two photosensitizers (BF-200 ALA versus MAL)
    Medical condition: Actinic keratosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014833-26 Sponsor Protocol Number: IEO S500/409 Start Date*: 2010-07-29
    Sponsor Name:ISTITUTO EUROPEO DI ONCOLOGIA
    Full Title: Phase IIB Randomized, Placebo Controlled Trial of Pioglitazone for Oral Premalignant Lesions. An Inter-Consortium Collaborative Study.
    Medical condition: oral premalignant lesions
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024396 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005576-28 Sponsor Protocol Number: VB-C-01 Start Date*: 2015-07-13
    Sponsor Name:VACCIBODY A.S.
    Full Title: An Exploratory Safety and Immunogenicity Study of Human Papillomavirus (HPV16+) Immunotherapy VB10.16 in Women with High Grade Cervical Intraepithelial Neoplasia (HSIL; CIN 2/3)
    Medical condition: High grade cervical intraepithelial neoplasia (HSIL, CIN 2/3)
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-020227-48 Sponsor Protocol Number: 113618 Start Date*: 2011-01-07
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase IIIb, open-label, multi-centre immunization study to evaluate the safety of GlaxoSmithKline (GSK) Biologicals’ HPV-16/18 L1 VLP AS04 vaccine administered intramuscularly according to a 0, 1...
    Medical condition: Cervarix is indicated in females from 10 years of age onwards for the prevention of premalignant cervical lesions and cervical cancer causally related to Human Papillomavirus (HPV) types 16 and 18....
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: PT (Completed)
    Trial results: View results
    EudraCT Number: 2019-004050-29 Sponsor Protocol Number: Vvax001-UMCG-02 Start Date*: 2020-03-30
    Sponsor Name:University Medical Center Groningen
    Full Title: A phase II study to determine the efficacy and safety of Vvax001, a therapeutic Semliki Forest Virus based cancer vaccine, in patients with HPV-16 induced grade 3 cervical intraepithelial neoplasia.
    Medical condition: HPV-16 induced pre malignant cervical lesions
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000870-39 Sponsor Protocol Number: CHDR1607 Start Date*: 2017-08-21
    Sponsor Name:Cutanea Life Sciences
    Full Title: A phase 2, randomized, vehicle-controlled, double-blind study to explore the efficacy, pharmacodynamics and safety of topical ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide i...
    Medical condition: HPV-induced genital lesions of immunocompromised and immunocompetent patients
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000016515 10018182 Genital warts LLT
    20.0 100000024086 10064455 HSIL LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-023935-41 Sponsor Protocol Number: PET-BRCA-2010 Start Date*: 2011-03-22
    Sponsor Name:Consorcio de Apoyo a la Investigación Biomédica en Red (CAIBER)
    Full Title: PILOT STUDY ASSESSING THE EFFECTIVENESS OF 18FDG PET-CT IN THE EARLY DIAGNOSIS OF BREAST CANCER AND / OR OVARIAN CANCER IN WOMEN BRCA1 or BRCA 2 MUTATION CARRIERS
    Medical condition: Breast cancer screening in women BRCA1 or BRCA2 mutation.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002096-96 Sponsor Protocol Number: NL57849.068.16 Start Date*: 2016-09-20
    Sponsor Name:Maastricht University Medical Center
    Full Title: TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia, a multicenter, open-label, non-randomized, controlled study (TOPIC-3 study)
    Medical condition: High-grade Cervical Intraepithelial Neoplasia
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006773-32 Sponsor Protocol Number: HPV_CSP01 Start Date*: 2009-05-20
    Sponsor Name:Health Protection Agency
    Full Title: A Phase IV, randomised study to evaluate the immune responses of UK adolescent girls receiving Cervarix(TM) or Gardasil(TM) Human Papillomavirus vaccines
    Medical condition: This study will investigate vaccines that prevent premalignant cervical lesions and cervical cancer causally related to Human Papillomavirus (HPV) types 16 and 18. This study will investigate wheth...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058580 Human papilloma virus serology test LLT
    Population Age: Adolescents, Under 18 Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-001528-38 Sponsor Protocol Number: PROSKIN 01 Start Date*: 2007-01-12
    Sponsor Name:Charité Universitätsmedizin Berlin
    Full Title: Prevention of skin cancer in high risk patients after conversion a to Sirolimus-based immunosuppressive
    Medical condition: Medical condition: renal transplant-patients at high-risk for skin cancer Transplant recipients have a high risk to develop skin malignancies. This depends on the immunosuppressive drugs and is rel...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-018399-25 Sponsor Protocol Number: MuSH_1.2 Start Date*: 2011-03-17
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik für Zahn-,Mund-u.Kieferheilkunde,Klin.Abt.f.orale Chirurg
    Full Title: A randomized controlled trial: Photodynamic Treatment for the therapy of premalignant mucosal oral lesions.
    Medical condition: Leukoplakia and oral lichen ruber.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10062037 Leukoplakia LLT
    12.1 10062037 Leukoplakia PT
    12.1 10030983 Oral lichen planus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-003836-77 Sponsor Protocol Number: OCTO-003 Start Date*: 2008-12-09
    Sponsor Name:University of Oxford
    Full Title: AspECT - A phase III, randomised study of aspirin and esomeprazole chemoprevention in Barrett's metaplasia & oesophagitis.
    Medical condition: Barrett's Metaplasia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000060-17 Sponsor Protocol Number: 200255 Start Date*: 2014-05-09
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase IIIb, open-label, non-randomised, multicentre study to assess the immunogenicity and safety of GSK Biologicals’ HPV-16/18 L1 VLP AS04 vaccine when administered intramuscularly according to ...
    Medical condition: Healthy volunteers [For active immunisation of females from 9 years of age onwards for the prevention of persistent infection, premalignant genital (cervical, vulvar and vaginal) lesions and cervic...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004865 10071147 Human papilloma virus immunization LLT
    16.1 100000004848 10058580 Human papilloma virus serology test LLT
    Population Age: Adolescents, Under 18, Adults Gender: Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-000416-42 Sponsor Protocol Number: 106069 Start Date*: 2017-09-15
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase IIIb, double-blind, randomized, controlled, multicentre study to assess the immunogenicity and safety of GlaxoSmithKline Biologicals’ HPV-16/18 L1 AS04 vaccine administered intramuscularly ...
    Medical condition: Healthy volunteers [For active immunisation of healthy adolescents and young adult females from the age of 10 to 25 years for the prevention of persistent infection, premalignant genital (cervical,...
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2015-002663-42 Sponsor Protocol Number: TFDTRASP Start Date*: 2015-11-13
    Sponsor Name:Clínica Universidad de Navarra/Universidad de Navarra
    Full Title: RANDOMISED PILOT STUDY TO ASSESS THE CLINICAL EFFICACY OF DAYLIGHT PHOTODYNAMIC THERAPY WITH METHYL AMINOLEVULINATE CREAM (METVIX?), (MAL-PDT), IN THE PREVENTION OF ACTINIC KERATOSIS AND NON MELANO...
    Medical condition: Actinic Keratosis (AK) are histologically characterized by the proliferation of keratinocytes with atypical cytology in the epidermis. One of the main risk factors for its occurrence is immunosuppr...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2021-003895-15 Sponsor Protocol Number: 82720 Start Date*: 2022-02-23
    Sponsor Name:Bispebjerg Hospital, Department of Dermatology and Venereology
    Full Title: Impact of human papillomavirus (HPV) vaccination on burden of disease in patients with actinic keratosis ― a double-blind randomized controlled trial
    Medical condition: Actinic Keratosis (AK)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004858 10052567 Skin preneoplastic conditions NEC HLT
    20.0 100000004858 10040901 Skin neoplasms malignant and unspecified (excl melanoma) HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001586-21 Sponsor Protocol Number: 5FUdPDT78842 Start Date*: 2021-09-22
    Sponsor Name:Bispebjerg Hospital, Department of Dermatology
    Full Title: Does 4% 5-fluorouracil pre-treatment improve the efficacy of daylight photodynamic therapy for actinic keratoses – a randomized controlled study
    Medical condition: Actinic keratosis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004858 10041304 Solar keratosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Thu May 15 19:32:50 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA