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Clinical trials for Probiotic

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44393   clinical trials with a EudraCT protocol, of which   7405   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    53 result(s) found for: Probiotic. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2004-002685-38 Sponsor Protocol Number: 2-2 Start Date*: 2005-08-05
    Sponsor Name:Yakult Honsha Co
    Full Title: Randomised controlled trial of metronidazole and probiotic preparation versus placebo in the treatment of irritable bowel syndrome
    Medical condition: Irritable Bowel Syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-000379-14 Sponsor Protocol Number: APC009 Start Date*: 2006-04-07
    Sponsor Name:Alimentary Health Ltd
    Full Title: A double-blind randomised placebo controlled feeding study to establish the effect of a probiotic strain on the course of Clostridium difficile carriage in humans.
    Medical condition: Clostridium difficile infection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-001769-35 Sponsor Protocol Number: OYS042020. Start Date*: Information not available in EudraCT
    Sponsor Name:Oulu University Hopsital
    Full Title: Preventing urinary tract infections in infants and young children with probiotic E. coli Nissle: FinNiss- trial
    Medical condition: Urinary tract infection
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-001324-31 Sponsor Protocol Number: 16/2008/O/Sper Start Date*: 2008-07-09
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: Efficacy and security of oral supplementation with a probiotic (Lactobacillus reuteri) in newborns with birth weight < 1500 g: effects on necrotising enterocolitis (NEC) and gut colonization with g...
    Medical condition: necrotising enterocolitis (NEC
    Disease: Version SOC Term Classification Code Term Level
    9.1 10014878 Enteritis necroticans LLT
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-001542-18 Sponsor Protocol Number: AAD-EU2012 Start Date*: 2012-07-12
    Sponsor Name:DuPont Nutrition and Health Active Nutrition
    Full Title: Effect of a probiotic formula on reducing the risk for antibiotic-associated diarrhea
    Medical condition: Antibiotic-associated diarrhea
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10002739 Antibiotic-associated diarrhea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002343-99 Sponsor Protocol Number: 1.0 Start Date*: 2012-01-03
    Sponsor Name:Heart of England NHS Foundation Trust
    Full Title: An Open-label Study into the Efficacy and Dosing of Probiotic Escherichia coli Nissle 1917 for Prevention of Gram-negative Gastric Colonisation in Ventilated Intensive Care Patients.
    Medical condition: Gastric colonisation by pathogenic gram negative bacteria in ventilated adult ICU patients and it's prevention by the probiotic E.coli Nissle 1917
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007977-21 Sponsor Protocol Number: GS07/8360 Start Date*: 2008-11-12
    Sponsor Name:Leeds Teaching Hospitals Trust
    Full Title: ASSESSMENT OF THE ROLE OF THE PROBIOTIC VSL3® IN THE TREATMENT OF POUCHITIS AFTER ILEAL POUCH-ANAL ANASTOMOSIS
    Medical condition: This study aims to assess the bacterial flora in patients with healthy pouches and patients with have pouchitis. We aim to study the clinical and microbiological effectiveness of antibiotic and pro...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2006-003445-17 Sponsor Protocol Number: BBG001 Start Date*: 2009-05-12
    Sponsor Name:Queen Mary, University of London
    Full Title: The probiotic Bifidobacterium breve strain BBG-01 admistered early to preterm infants to prevent infection, necrotising enterocolitis and death.
    Medical condition: Necrotising enterocolitis in the preterm baby Late-onset (>72h of age) blood stream infection in the preterm baby Death of preterm babies before discharge from hospital
    Disease:
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-007179-18 Sponsor Protocol Number: LACTO 07 Start Date*: 2008-02-15
    Sponsor Name:SOFAR SPA
    Full Title: Evaluation of the ability of the probiotic Lactobacillus casei DG (Enterolactis) to remain into the bladder of patients with spinal cord injury and subject to intermitted catheterization. An open-l...
    Medical condition: patients with spinal cord injury and subject to intermitted vesical catheterization and recurrence of urinary tract infections
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054088 Urinary tract infection bacterial LLT
    Population Age: Adults Gender: Male
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-003944-38 Sponsor Protocol Number: 15-PP-13 Start Date*: 2016-04-19
    Sponsor Name:CHU NICE
    Full Title: Treatment of the oral aphtose récidivante and idiopathique of the adult by probiotics Double-blind randomized interventional study versus placebo
    Medical condition: aphtous stoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2020-000228-20 Sponsor Protocol Number: 16012020001 Start Date*: 2020-08-28
    Sponsor Name:Medical University of Graz
    Full Title: Probiotic dietary Intervention in Polycystic Ovary Syndrome – A Randomized Controlled Trial
    Medical condition: Polycystic Ovary Syndrome (PCOS) is a hormonal and metabolic disorder affecting up to 20 percent of women worldwide, depending on diagnostic criteria. A very common definition of PCOS based on the ...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001793-15 Sponsor Protocol Number: Gastro_CHU_16-1 Start Date*: 2016-07-12
    Sponsor Name:LactoResearch sprl
    Full Title: PROSPECTIVE STUDY OF THE EFFICIENCY OF PROBIOTIC MIXTURE TO IMPROVE LACTOSE DIGESTION AND SYMPTOMS OF LACTOSE INTOLERANCE
    Medical condition: lactose intolerance
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004861 10023682 Lactose intolerant LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000008-34 Sponsor Protocol Number: 07.IBS.1 Start Date*: 2007-09-13
    Sponsor Name:North West London Hospitals NHS Trust
    Full Title: Bacteria and host immune response as factors modulating visceral afferent processing in Irritable Bowel Syndrome: manipulation of visceral hypersensitivity with probiotic bacteria
    Medical condition: Irritable Bowel Syndrome
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023003 Irritable bowel syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-000868-34 Sponsor Protocol Number: ZKES-EcNO-2015 Start Date*: 2015-05-29
    Sponsor Name:ZKES GmbH
    Full Title: Randomized, placebo controlled phase III trial of a microbiological concomitant therapy/prevention of chemotherapeutical induced diarrhea (caused by inflammation and an impaired intestinal barrier)...
    Medical condition: Gastric or colorectal cancers, where a treatment with 5-Fluoruracil and one further chemotherapeutic remedy (either irinotecan or a platinum based chemotherapeutic remedy) is planned.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003140-56 Sponsor Protocol Number: D200 Probørn Start Date*: 2006-02-10
    Sponsor Name:Department of Human Nutrition, The Royal Veterinary and Agricultural University
    Full Title: Probiotics to infants with atopic dermatitis; an investigation of the effect on eczema, immune system and intestinal microflora, inflammation and permeability. DK-titel Probiotiske bakterier til ...
    Medical condition: Infants participating in the clinical trial are suffering from atopic dermatitis
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-002116-10 Sponsor Protocol Number: i3.1_IBS+SIBO Start Date*: 2019-09-27
    Sponsor Name:AB-Biotics S.A.
    Full Title: Interventional post-marketing study to evaluate i3.1 efficacy on SIBO (Small Intestinal Bacterial Overgrowth)reduction in IBS (Irritable bowel syndrom) patients
    Medical condition: Irritable Bowel Syndrome (IBS) + Small Intestinal Bacterial Overgrowth (SIBO)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002876-32 Sponsor Protocol Number: AAD-CDD-001 Start Date*: 2008-10-06
    Sponsor Name:University of Wales Swansea
    Full Title: A multicentre, randomised, placebo controlled trial of lactic acid bacteria in the prevention of antibiotic-associated diarrhoea (AAD) and Clostridium difficile diarrhoea (CDD) in patients aged 65 ...
    Medical condition: AAD is diarrhoea occurring in association with antibiotic treatment without an alternative cause. It occurs typically 2-8 weeks after exposure to antibiotics. The frequency of AAD varies markedly b...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064065 Prophylaxis against diarrhoea PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001240-19 Sponsor Protocol Number: CSL16001 Start Date*: 2016-08-22
    Sponsor Name:Synlogic
    Full Title: Clearance of the probiotic strain Escherichia coli Nissle 1917 in the gastrointestinal tract of healthy volunteers
    Medical condition: Healthy volunteers trial, intended indication: Colitis ulcerosa in phase of remission, Chronic constipation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BG (Completed)
    Trial results: View results
    EudraCT Number: 2006-002963-23 Sponsor Protocol Number: Not available Start Date*: 2006-08-03
    Sponsor Name:Chr. Hansen A/S
    Full Title: The effect of probiotics on bloating in IBS
    Medical condition: Meteorism symptoms in women dominated by bloating
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-001076-14 Sponsor Protocol Number: K12-2020 Start Date*: 2020-04-20
    Sponsor Name:Oulu University Hospital, Oulu, Finland [...]
    1. Oulu University Hospital, Oulu, Finland
    2. University of Oulu
    Full Title: Efficacy of Streptococcus salivarius K12 oral probiotic products in preventing acute otitis media: A randomized placebo-controlled trial.
    Medical condition: Acute otitis media
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10033084 Otitis media NOS LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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