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Clinical trials for Saliva

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    242 result(s) found for: Saliva. Displaying page 1 of 13.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2007-004654-81 Sponsor Protocol Number: DL06001/02 Start Date*: 2007-12-20
    Sponsor Name:Summit (Cambridge) Ltd.
    Full Title: A phase IIa study to evaluate the relative efficacy and safety/tolerability of a single agent vs. a combination treatment for reducing saliva secretion in Parkinson’s disease patients
    Medical condition: Sialorrhoea associated with Parkinson's Disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10059812 Sialorrhoea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-020014-28 Sponsor Protocol Number: CHDR0905 Start Date*: 2010-05-11
    Sponsor Name:Centre for Human Drug Research
    Full Title: Pharmacokinetics in Plasma and Saliva of a Single Dose Immediate- or Extended Release Methylphenidate in Healthy Volunteers.
    Medical condition: N/A; pharmacokinetic study. Methylphenidate is indicated in ADHD and narcolepsia.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-004532-30 Sponsor Protocol Number: MRZ60201_3091_1 Start Date*: 2014-12-09
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: Prospective, randomized, double-blind, placebo-controlled, parallel-group, multicenter study with an open-label extension period to investigate the efficacy and safety of NT 201 in the treatment of...
    Medical condition: Chronic troublesome sialorrhea associated with neurological disorders (e.g. cerebral palsy, traumatic brain injury) and/or intellectual disability in children and adolescents
    Disease: Version SOC Term Classification Code Term Level
    19.0 10017947 - Gastrointestinal disorders 10039424 Salivary hypersecretion PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) PL (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-005355-32 Sponsor Protocol Number: IIV-275 Start Date*: 2014-03-06
    Sponsor Name:National Institute for Public Health and the Environment (RIVM, the Netherlands)
    Full Title: Memory response against Bordetella pertussis in adults: immunological effects of an acellular pertussis booster vaccination
    Medical condition: The vaccine administered in this study is used to prevent pertussis caused by the bacterium Bordetella pertussis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000682-30 Sponsor Protocol Number: 01-09.02.15. Start Date*: 2015-04-27
    Sponsor Name:Tartu University Hospital
    Full Title: Botulinum neurotoxin type A treatment for sialorrhea in central nervous system diseases
    Medical condition: Hypersalivation
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10020746 Hypersalivation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: View results
    EudraCT Number: 2005-000901-77 Sponsor Protocol Number: A/220/05 Start Date*: 2007-07-12
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: Treatment of sialorrhoea with botulinum toxin in patients with neurodegenerative diseases
    Medical condition: sialorrhoea in patients with neurodegenerative diseases
    Disease: Version SOC Term Classification Code Term Level
    9.1 10039424 Salivary hypersecretion LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-016300-23 Sponsor Protocol Number: RAA 2009-007 Start Date*: 2009-12-14
    Sponsor Name:King's College London
    Full Title: Pilot double blind randomised placebo controlled crossover trial of Hyoscine for the treatment of Clozapine induced nocturnal sialorrhoea.
    Medical condition: Sialorrhoea in patients treated with clozapine.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10059812 Sialorrhoea LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-021691-28 Sponsor Protocol Number: DAMS-7 Start Date*: 2011-11-04
    Sponsor Name:Hospital Vall d'Hebron
    Full Title: PILOT CLINICAL TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF BOTULINUM NEUROTOXIN TYPE- A IN SALIVARY GLANDS IN THE TREATMENT OF CHRONIC DROOLING IN PATIENTS WITH CEREBRAL PALSY: A CONTROLLED CLINIC...
    Medical condition: Hypersalivation (chronic sialorrhea)in patients with cerebral palsy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10017947 - Gastrointestinal disorders 10039424 Salivary hypersecretion PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-005539-10 Sponsor Protocol Number: MRZ60201_3090_1 Start Date*: 2014-04-29
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: Prospective, randomized, double-blind, placebo-controlled, parallel-group multicenter study, with an extension period of dose-blinded active treatment, to investigate the efficacy and safety of two...
    Medical condition: Chronic troublesome sialorrhea resulting from neurological conditions in adults with Parkinson's disease or atypical parkinsonism (multiple system atrophy, corticobasal degeneration or progressive ...
    Disease: Version SOC Term Classification Code Term Level
    18.1 10017947 - Gastrointestinal disorders 10039424 Salivary hypersecretion PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-005451-23 Sponsor Protocol Number: T-01 Start Date*: 2009-05-27
    Sponsor Name:Charité - Universitätsmedizin Berlin, CharitéCentrum 3 für Zahn-, Mund- und Kieferheilkunde
    Full Title: Vergleichende, randomisierte, kontrollierte und doppelblinde In-situ-Studie zur Wirkung von Speichelersatzmitteln auf Schmelz und Dentin
    Medical condition: Xerostomia and substantial relief of the symptoms by saliva substitutes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-000169-19 Sponsor Protocol Number: Start Date*: 2019-09-03
    Sponsor Name:Queen Mary University London
    Full Title: Clinical trial to determine the effect of Famciclovir on Epstein-Barr virus activity as measured by EBV shedding in saliva of patients with Multiple Sclerosis.
    Medical condition: Epstein Barr virus infection in people with multiple sclerosis.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029205 - Nervous system disorders 10028245 Multiple sclerosis PT
    20.0 100000004862 10014077 EBV infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2005-000974-29 Sponsor Protocol Number: TH0501 Start Date*: 2005-04-01
    Sponsor Name:Boots Healthcare International Limited
    Full Title: An open label, oral bioavailability study to determine the levels of Amylmetacresol BP (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) in the saliva of healthy volunteers after a single oral dose of S...
    Medical condition: AMC and DCBA are indicated for the symptomatic relief of mouth and throat infections.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000360-30 Sponsor Protocol Number: FEPODPara2021-1 Start Date*: 2021-05-03
    Sponsor Name:Helsinki University Hospital
    Full Title: Determination of serum paracetamol concentration with an electrochemical measurement tool from blood and saliva samples in patients using also other medication.
    Medical condition: Patients with any medical condition that requires regular medication and who are undergoing elective surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-001631-36 Sponsor Protocol Number: CPL061-01 Start Date*: 2015-02-02
    Sponsor Name:Colonis Pharma Limited
    Full Title: A Double-blind, Randomised, Placebo Controlled Study of the Efficacy of Glycopyrronium bromide 1mg /5ml in the Treatment of Non-drug Induced Hypersalivation with an Open Single-arm Extension to Inv...
    Medical condition: Neurodevelopmental disability associated with hypersalivation
    Disease: Version SOC Term Classification Code Term Level
    17.1 10037175 - Psychiatric disorders 10064062 Neurodevelopmental disorder PT
    17.1 100000004856 10020746 Hypersalivation LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: CZ (Completed) SK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000213-33 Sponsor Protocol Number: 14012020 Start Date*: 2020-04-21
    Sponsor Name:Department of Dentistry and Oral Health
    Full Title: Fluoride in saliva during and after use of high-fluoride toothpaste
    Medical condition: Not applicable. A physiological phenomena is explored.
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004848 10053349 Pharmacokinetic study LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-001468-21 Sponsor Protocol Number: KIIOIW001 Start Date*: 2006-08-24
    Sponsor Name:Karolinska Institutet
    Full Title: Sympthomatic and prophylactic treatment of drug induced oral dryness in elderly patients with high drug consumption.
    Medical condition: Oral dryness is a common problem with serious consquences, especially among elderly individuals. The most common reason for oral dryness is drug consumption. Research has shown that an individual w...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-002708-14 Sponsor Protocol Number: OML0113 Start Date*: 2013-10-09
    Sponsor Name:Schülke & Mayr GmbH
    Full Title: Phase II study to assess bacterial count reduction of three Octenidine mouthwash concentrations in comparison to a placebo in patients with mild gingivitis
    Medical condition: patients aged 18 and older with mild gingivitis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10018292 Gingivitis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-001720-19 Sponsor Protocol Number: XRS-ITRT-2018 Start Date*: 2018-12-12
    Sponsor Name:Institut de Terapia Regenerativa Tissular S.L. (ITRT)
    Full Title: Phase II clinical trial to evaluate the effect and safety of MSV * in Xerostomia * adult autologous bone marrow mesenchymal stem cells, expanded under GMP of IBGM
    Medical condition: Xerostomia post radiotherapy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10048223 Xerostomia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-016668-35 Sponsor Protocol Number: HBO-CPH1 Start Date*: 2009-12-22
    Sponsor Name:Copenhagen University Hospital
    Full Title: Hyperbaric Oxygen - a new treatment modality in patients with salivary gland radiation injury
    Medical condition: Late radiation tissue injury to salivary glands
    Disease: Version SOC Term Classification Code Term Level
    12.0 10013781 Dry mouth LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000348-24 Sponsor Protocol Number: CVB2018-1 Start Date*: 2018-06-11
    Sponsor Name:Department of Otorhinolaryngology, Head and Neck Surgery
    Full Title: Mesenchymal stem cells for radiation-induced hyposalivation and xerostomia in previous head and neck cancer patients (MESRIX-II)
    Medical condition: The trial will include participants with Xerostomia (International Classification of Diseases-10: DQ 838A) who have been treated with raditherapy for a head and neck cancer prevoiusly.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10013781 Dry mouth PT
    20.0 10017947 - Gastrointestinal disorders 10048223 Xerostomia LLT
    20.0 100000004865 10039420 Salivary gland therapeutic procedures HLT
    20.0 10017947 - Gastrointestinal disorders 10039404 Salivary gland conditions HLGT
    21.1 10017947 - Gastrointestinal disorders 10039390 Salivary gland atrophy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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