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Clinical trials for Sphincter

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    83 result(s) found for: Sphincter. Displaying page 1 of 5.
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    EudraCT Number: 2008-004858-33 Sponsor Protocol Number: Version 2.0 (03Nov2010) Start Date*: 2009-01-09
    Sponsor Name:University College London
    Full Title: Open label pilot study to treat women with chronic urinary retention or voiding dysfunction due to a primary disorder of sphincter relaxation (Fowler’s syndrome) with outpatient urethral sphincter ...
    Medical condition: Primary abnormality of the urethral sphincter or Fowlers Syndrome
    Disease: Version SOC Term Classification Code Term Level
    9.1 10046456 Urethral instrinsic sphincter deficiency LLT
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-003759-11 Sponsor Protocol Number: FI 1 Start Date*: 2007-03-09
    Sponsor Name:BKH Schwaz
    Full Title: Autologous myoblasts for treatment of anal incontinence due to anal sphincter defects
    Medical condition: Fecal (anal) inconinence caused by ruptures/ traumas of the external anal sphincter
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000563-16 Sponsor Protocol Number: Citalopram2016 Start Date*: 2016-06-09
    Sponsor Name:K.U. Leuven
    Full Title: Effect of citalopram on fasting and postprandial lower esophageal sphincter function in healthy subjects: a double-blind, placebo-controlled, randomized, cross-over study
    Medical condition: Increased lower esophageal sphincter pressure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000532-17 Sponsor Protocol Number: Methylnaltrexone2016 Start Date*: 2016-06-09
    Sponsor Name:K.U. Leuven
    Full Title: Effect of methylnaltrexone on intragastric pressure, the occurrence of transient lower esophageal sphincter relaxations and reflux events in healthy subjects: a double-blind, placebo-controlled, ra...
    Medical condition: Impaired gastric accommodation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-004239-63 Sponsor Protocol Number: NL68231.078.18 Start Date*: 2019-08-23
    Sponsor Name:Erasmus MC
    Full Title: Botulinum toxin (BOTOX®) to prevent post-operative pancreatic fistula in patients who undergo distal pancreatectomy. PROFIT study.
    Medical condition: Post-operative pancreatic fistula
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10049192 Pancreatic fistula PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2005-002335-27 Sponsor Protocol Number: IGG-VIJA-001 Start Date*: 2005-09-01
    Sponsor Name:ISTITUTO GIANNINA GASLINI
    Full Title: Botulin Toxin injection for the treatment of Internal Anal Sphincter Achalasia
    Medical condition: Treatment of internal anal sphincter achalasia
    Disease: Version SOC Term Classification Code Term Level
    6.1 10042613 SOC
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002882-19 Sponsor Protocol Number: MCHT001 Start Date*: 2004-12-10
    Sponsor Name:Mid Cheshire Hospitals NHS Trust
    Full Title: A controlled trial into the benefit of topical perianal glyceryl trinitrate (GTN) as a sphincter relaxant, pre-insertion of ultrasound probe for trans rectal ultrasound (TRUS) guided biopsy of the ...
    Medical condition: Prostate Cancer Diagnosis – Pain relief during biopsy
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-004139-23 Sponsor Protocol Number: 62202-677 Start Date*: 2006-08-18
    Sponsor Name:University of Cologne
    Full Title: An open-label, non-randomized phase I/II trial of neoadjuvant radio-immunochemotherapy with cetuximab and 5-FU for advanced rectal cancer
    Medical condition: advanced adenocarcinoma of the rectum
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-000419-42 Sponsor Protocol Number: Nalogexol-2014 Start Date*: 2015-05-11
    Sponsor Name:Aalborg University Hospital
    Full Title: Naloxegol and assessments of opioid induced bowel dysfunction
    Medical condition: Healthy volunteers (Opioid-induced bowel dysfunction)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-001384-12 Sponsor Protocol Number: PancolonicPressurization Start Date*: 2014-07-16
    Sponsor Name:KULEUVEN
    Full Title: IS THE ABSENCE OF PAN-COLONIC PRESSURIZATIONS A RELEVANT PATHOPHYSIOLOGICAL MECHANISM IN A SUBGROUP OF PATIENTS WITH CHRONIC IDIOPHATIC CONSTIPATION?
    Medical condition: COLONIC MOTILITY WILL BE STUDIED BOTH IN HEALTHY SUBJECTS AND IN PATIENTS WITH CHRONIC CONSTIPATION
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-021463-32 Sponsor Protocol Number: IC-01-02-02-007 Start Date*: 2011-02-24
    Sponsor Name:Innovacell Biotechnologie AG
    Full Title: Skeletal muscle-derived cell implantation for the treatment of fecal incontinence: a multicenter, randomized, double-blind, placebocontrolled, parallel-group, dose-finding clinical study
    Medical condition: Fecal incontinence in female and male patients with external anal sphincter weakness or sphincter damage.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000167639 10016296 Fecal incontinence LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended) DE (Prematurely Ended) SE (Prematurely Ended) CZ (Prematurely Ended) GB (Prematurely Ended) SI (Prematurely Ended) BG (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-004501-25 Sponsor Protocol Number: D9120C00020 Start Date*: 2006-12-18
    Sponsor Name:AstraZeneca AB
    Full Title: A double-blind, placebo controlled, randomized, two centre phase IIa pharmacodynamic cross-over study to assess the effect of AZD3355, 65 mg bid, on transient lower esophageal sphincter relaxations...
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-001371-38 Sponsor Protocol Number: EMR 62202-688 Start Date*: 2006-08-31
    Sponsor Name:Institute of Oncology Ljubljana
    Full Title: Cetuximab (Erbitux®), capecitabine and radiotherapy in neoadjuvant treatment of patients with locally advanced resectable rectal cancer: A phase II Pilot Study
    Medical condition: Locally advanced, resectable stage II/III rectal cancer.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SI (Completed)
    Trial results: View results
    EudraCT Number: 2017-003582-10 Sponsor Protocol Number: AVANA Start Date*: 2019-01-17
    Sponsor Name:G.O.N.O. - GRUPPO ONCOLOGICO DEL NORD OVEST
    Full Title: PHASE II STUDY OF PREOPERATIVE CHEMORADIOTHERAPY PLUS AVELUMAB IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER
    Medical condition: Locally advanced rectal cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038038 Rectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000649-20 Sponsor Protocol Number: STAR-03 Start Date*: 2012-06-11
    Sponsor Name:FONDAZIONE DELL'ISTITUTO TOSCANO TUMORI
    Full Title: Phase II study of pre-operative treatment with external radiotherapy plus panitumumab in operable locally advanced rectal cancer (favourable and intermediate prognostic group) (RaP Study/STAR-03)
    Medical condition: Operable locally advanced rectal cancer
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038019 Rectal adenocarcinoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001178-28 Sponsor Protocol Number: FISPAC-2011 Start Date*: 2012-09-05
    Sponsor Name:Fundación para la Investigación Biomédica del Hospital Universitario La Paz
    Full Title: Multicentre, randomized, comparative and Add-on, in two parallel groups to assess the efficacy and safety of autologous mesenchymal stem cells derived from expanded adipose tissue (ASC) for the tre...
    Medical condition: Local treatment in complex perianal fistulas in patients without inflammatory bowel disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000853-30 Sponsor Protocol Number: DRGT119C01 Start Date*: 2019-05-31
    Sponsor Name:Druggability Technologies Holdings Ltd
    Full Title: A Randomized, Double-Blind, Adaptive Trial with an Open-Label Treatment Extension to Determine the Efficacy and Safety of Topical DRGT-119 0.1% and 0.2% Gels in Patients with Chronic Anal Fissure
    Medical condition: chronic anal fissure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-006081-29 Sponsor Protocol Number: Rimonaslok Start Date*: 2008-10-21
    Sponsor Name:UZLeuven
    Full Title: INFLUENCE OF RIMONABANT ON LOWER ESOPHAGEAL FUNCTION IN HEALTHY VOLUNTEERS
    Medical condition: none; this is a physiological study to investigate the influence of CB1 receptor antagonism by rimonabant (normally used for the treatment of obesity) on esophageal function, i.e. esophageal contr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2013-004672-35 Sponsor Protocol Number: 09-025 Start Date*: 2014-05-13
    Sponsor Name:Cook Myosite, Incorporated
    Full Title: A Prospective Nonrandomized Study of Autologous Muscle Derived cell (AMDC) Transplantation for Treatment of Fecal Incontinence
    Medical condition: Fecal incontinence in men and women
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10016296 Fecal incontinence LLT
    20.0 100000004856 10055507 Fecal incontinence aggravated LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2011-006310-13 Sponsor Protocol Number: CAO/ARO/AIO-12 Start Date*: 2015-01-19
    Sponsor Name:University Hospital Frankfurt, Goethe University
    Full Title: CAO/ARO/AIO-12: Induction chemotherapy before or after preoperative chemoradiotherapy and surgery for locally advanced rectal cancer: A randomized phase II trial of the German Rectal Cancer Study ...
    Medical condition: Locally advanced rectal cancer (UICC stage II and III)
    Disease: Version SOC Term Classification Code Term Level
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038050 Rectal cancer stage III PT
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038049 Rectal cancer stage II PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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