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Clinical trials for Titration

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    464 result(s) found for: Titration. Displaying page 1 of 24.
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    EudraCT Number: 2006-003519-33 Sponsor Protocol Number: D1443L00003 Start Date*: 2007-01-25
    Sponsor Name:AstraZeneca UK Limited
    Full Title: RAPID - An Open-Label, Randomised, Multicentre Phase IIIb Study to Evaluate the Efficacy and Tolerability of Quetiapine IR (Immedicate Release), over 14 days, in Acute Schizophrenia / Schizoaffecti...
    Medical condition: Acute Schizophrenia and Schizoaffective Disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-004224-59 Sponsor Protocol Number: MK-0431-848 Start Date*: 2016-07-27
    Sponsor Name:Merck Sharp & Dohme Corp.
    Full Title: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Study the Safety and Efficacy of the Addition of Sitagliptin During Metformin Up-titration Compared with Met...
    Medical condition: Type 2 Diabetes mellitus
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2016-002474-13 Sponsor Protocol Number: 3.199 Start Date*: 2017-04-24
    Sponsor Name:Innovatiefonds Zorgverzekeraars
    Full Title: Medication Optimization for ADHD: MOVA study Implementation and evaluation of double-blind placebo-controlled titration in clinical practice
    Medical condition: Attention Deficit Hyperactivity Disorder
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006426-26 Sponsor Protocol Number: D1443L00009 Start Date*: 2007-01-17
    Sponsor Name:AstraZeneca AB
    Full Title: FAST – A randomised, open-label, parallel, multicentre Phase IIIb Study to evaluate the Efficacy and Safety of Quetiapine IR titrared over 4 Days in Patients with Acute Psychosis (Rapid versus Conv...
    Medical condition: Patients requiring treatment, as judged by the Investigator, for an acute episode of schizophrenia, schizoaffective disorder, psychosis NOS or bipolar mania (according to DSM-IV criteria).
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-002020-17 Sponsor Protocol Number: 10908458 Start Date*: 2005-02-23
    Sponsor Name:Catalan Society of Family Medicine, represented by Dr Mariano de la Figuera Von Wichman and Gabriel
    Full Title: ESTRATEGIAS PARA EL TRATAMIENTO DE LA HIPERTENSIÓN ARTERIAL. EVALUACIÓN DE UNA TERAPIA COMBINADA A DOSIS FIJAS (LOSARTÁN/HIDROCLOROTIAZIDA) vs MONOTERAPIA (ESTRATAAR). (STRATEGIES FOR THE TREATMENT...
    Medical condition: Stage II arterial Hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001788-21 Sponsor Protocol Number: RO-2455-302-RD Start Date*: 2014-04-11
    Sponsor Name:TAKEDA DEVELOPMENT CENTRE EUROPE LTD
    Full Title: A multicenter, randomized, double-blind phase 3 study to evaluate tolerability and pharmacokinetics of 500μg roflumilast once daily with an up-titration regimen in COPD, including an open-label do...
    Medical condition: chronic obstructive pulmonary disease (COPD)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SK (Completed) DE (Completed) HU (Completed) RO (Completed) GR (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2005-002544-25 Sponsor Protocol Number: CL_700_002_PRO-AME3 Start Date*: 2006-01-02
    Sponsor Name:LAB Pharma Ltd
    Full Title: A Multicentre, Multinational, Open-Label Trial (including Double-Blind, Placebo-Controlled Cross-Over Extension Part) to Evaluate the Time to Significant Pain Relief with Fentanyl TAIFUN® in the Tr...
    Medical condition: Patients with cancer having episodes of breakthrough pain
    Disease: Version SOC Term Classification Code Term Level
    7.1 10058019 canc
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-002131-27 Sponsor Protocol Number: SCO/BIA-2093-203 Start Date*: 2005-09-27
    Sponsor Name:BIAL - Portela & Ca, S.A.
    Full Title: Efficacy and safety of eslicarbazepine acetate (BIA 2-093) in acute manic episodes associated with bipolar I disorder in a double-blind, randomised, dose-titration, placebo-controlled, multicenter ...
    Medical condition: Patients with acute manic episode fulfilling DSM-IV criteria for Bipolar I Disorder (i.e., 296.0, 296.4 or 296.6)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) SK (Completed) CZ (Completed) DE (Completed) PT (Completed)
    Trial results: View results
    EudraCT Number: 2009-009115-22 Sponsor Protocol Number: IGG-LR-08 Start Date*: 2009-05-04
    Sponsor Name:ISTITUTO GIANNINA GASLINI
    Full Title: Fenoldopam mesilate efficacy to control splancnic ischemia during cardiopulmonary bypass in pediatric patients
    Medical condition: cardiac surgery with CPB
    Disease: Version SOC Term Classification Code Term Level
    9.1 10042613 SOC
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003376-37 Sponsor Protocol Number: CVAH631D2301 Start Date*: 2005-12-12
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 6-week, multicenter, randomized, double-blind, parallel-group study to evaluate the combination of valsartan/HCTZ (160/12.5 mg with forced titration to a maximum dose of 320/25 mg) compared to va...
    Medical condition: Severe hypertension (MSDBP ≥ 110 mmHg and < 120 mmHg).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) SI (Completed)
    Trial results: View results
    EudraCT Number: 2015-003077-15 Sponsor Protocol Number: EIG-LNF-002 Start Date*: 2015-11-23
    Sponsor Name:Eiger BioPharmaceuticals
    Full Title: A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Activity of Titrating-Dose Lonafarnib in Combination with Ritonavir in Patients Chronically Infected w...
    Medical condition: Chronic Hepatitis D Virus (HDV) Infection.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2004-002894-21 Sponsor Protocol Number: CDAR328A2409 Start Date*: 2005-06-21
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 12-week, randomized, double-blind, placebo-controlled, parallel group, multicenter study to evaluate the efficacy, safety and tolerability of darifenacin (7.5 mg o.d. with voluntary up-titration...
    Medical condition: Overactive bladder (OAB)
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed) HU (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2004-000957-47 Sponsor Protocol Number: 12052004 Start Date*: 2007-11-22
    Sponsor Name:Charité
    Full Title: Comparison of Bisoprolol and Carvedilol in elderly patients with heart failure. A randomised doubleblind multicenter trial
    Medical condition: Patients, 65 years or older, suffering from chronic heart failure and who are so far not treated with betablockers or treated with a low dose betablocker (<1/4 standard dose)
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SI (Completed)
    Trial results: View results
    EudraCT Number: 2019-003757-28 Sponsor Protocol Number: MEX-NM-301 Start Date*: 2020-06-24
    Sponsor Name:Lupin Europe GmbH
    Full Title: An Open-label, non-Comparative Study to Evaluate the Steady-State Pharmacokinetics, Safety, and Efficacy of Mexiletine in Adolescents and Children with Myotonic Disorders
    Medical condition: Myotonic disorders: Nondystrophic myotonias (NDM) or myotonic dystrophies (DM, type 1 or type 2); ICD-10 code G71.1
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10028658 Myotonic disorders LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-005122-45 Sponsor Protocol Number: D1441L00032 Start Date*: 2005-05-18
    Sponsor Name:AstraZeneca GmbH
    Full Title: RACE : Rapid Dose Escalation of Quetiapine versus Conventional Escalation in the Treatment of Patients with Acute Schizophrenia – a Multicentre, Double-blind, Parallel group, Randomized Study
    Medical condition: Patients hospitalised with a DSM-IV diagnosis of schizophrenia showing acute agitation and psychosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2004-004620-12 Sponsor Protocol Number: dyspnoea1 Start Date*: 2005-01-14
    Sponsor Name:Royal Marsden Hospital
    Full Title: Assessment of normal release morphine in the management of dyspnoea
    Medical condition: Breathlessness of any cause in cancer patients are identified and treated with normal release morphine which has been shown to be both effective and safe.The idea of the trial is to see if there wi...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-001835-33 Sponsor Protocol Number: CLCZ696B2228 Start Date*: 2013-09-19
    Sponsor Name:Novartis Pharma services AG
    Full Title: A multicenter, randomized, double-blind, parallel group study to assess the safety and tolerability of initiating LCZ696 in heart failure patients comparing two titration regimens.
    Medical condition: Chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004849 10008908 Chronic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) IT (Completed) SK (Completed) ES (Completed) DE (Completed) FI (Completed) GB (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2012-004625-25 Sponsor Protocol Number: NN9068-4056 Start Date*: 2014-08-29
    Sponsor Name:Novo Nordisk A/S
    Full Title: A clinical trial comparing efficacy and safety of insulin degludec/liraglutide (IDegLira) in subjects with type 2 diabetes mellitus using two different titration algorithms
    Medical condition: Diabetes Mellitus, Type 2
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004861 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) BG (Completed) AT (Completed) SK (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2010-022304-50 Sponsor Protocol Number: NN1250-3847 Start Date*: 2011-02-02
    Sponsor Name:Novo Nordisk A/S
    Full Title: A trial comparing the efficacy and safety of insulin degludec three times weekly in insulin naïve subjects with type 2 diabetes mellitus when titrated using two different titration algorithms
    Medical condition: Type 2 Diabetes
    Disease: Version SOC Term Classification Code Term Level
    12.1 10067585 Type 2 diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Completed) HU (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-005788-27 Sponsor Protocol Number: SP874 Start Date*: 2006-06-16
    Sponsor Name:SCHWARZ BIOSCIENCES GmbH
    Full Title: A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL TO ASSESS THE EFFICACY AND SAFETY OF 400MG/DAY LACOSAMIDE IN SUBJECTS WITH PAINFUL DISTAL DIABETIC NEUROPATHY USING TWO DIFFERENT ...
    Medical condition: Painful distal diabetic neuropathy
    Disease: Version SOC Term Classification Code Term Level
    6.0 10012680 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) AT (Completed) HU (Completed) FI (Completed) CZ (Completed) ES (Completed) DE (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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