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Clinical trials for Treatment as Prevention

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    1,611 result(s) found for: Treatment as Prevention. Displaying page 1 of 81.
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    EudraCT Number: 2020-001251-41 Sponsor Protocol Number: P20/05 Start Date*: 2020-04-17
    Sponsor Name:CH de Versailles
    Full Title: A PROOF OF CONCEPT STUDY TESTING THE VALUE OF IMATINIB IN PREVENTION OF COVID-19 IN AGED PATIENTS.
    Medical condition: Aged patients at risk of COVID-19 infection
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10051905 Coronavirus infection LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-019507-28 Sponsor Protocol Number: C-09-055 Start Date*: 2010-10-15
    Sponsor Name:Alcon Research, Ltd.
    Full Title: Clinical Evaluation of Nepafenac Ophthalmic Suspension, 0.3% for Prevention and Treatment of Ocular Inflammation and Pain after Cataract Surgery
    Medical condition: The Prevention and Treatment of Ocular Inflammation and Pain after Cataract Surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) SE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003574-28 Sponsor Protocol Number: THYTECH1-2018-005 Start Date*: 2019-11-26
    Sponsor Name:Rafael Correa Rocha
    Full Title: Phase I / II clinical trial, randomized, exploratory and prospective to evaluate the safety and efficacy of the transfusion of autologous TREG cells obtained from thymic tissue in the prevention of...
    Medical condition: To evaluate the efficacy in the prevention of the rejection of the transfusion of autologous thyTreg cells in children transplanted from the heart
    Disease:
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000131-13 Sponsor Protocol Number: DDD17CRCCXB1 Start Date*: 2017-05-11
    Sponsor Name:KU Leuven
    Full Title: Pharmacokinetics of Celebrex for the prevention/treatment of colorectal cancer: Systemic pharmacokinetics and elimination of Celebrex in healthy volunteers
    Medical condition: Colorectal cancer
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2007-002895-32 Sponsor Protocol Number: ML21308 Start Date*: 2007-08-29
    Sponsor Name:Roche AB
    Full Title: A phase II trial assessing Metronidazol Actavis 1% topical cream in the prevention and treatment of Erlotinib associated rash
    Medical condition: Erlotinib associated rash
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2018-000286-36 Sponsor Protocol Number: LEVODESA_04-2017 Start Date*: 2018-08-28
    Sponsor Name:NTC s.r.l.
    Full Title: An international, multicenter, randomized, blinded-assessor, parallel-group clinical study comparing eye drops of combined LEvofloxAcin + DExamethasone foR 7 days followed by dexamethasone alone fo...
    Medical condition: Prevention and treatment of inflammation and prevention of infection associated with cataract surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10007739 Cataract PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-000225-36 Sponsor Protocol Number: hss198 Start Date*: 2015-05-20
    Sponsor Name:Helsinki University Hospital
    Full Title: PBA (4-phenylbutyrate) in the prevention of intraocular pressure increase caused by glucocorticoids
    Medical condition: Intraocular pressure increase caused by glucocorticoid use in genetically predisposed patients
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-005524-11 Sponsor Protocol Number: FNO-IMUNOR-2020 Start Date*: 2020-12-21
    Sponsor Name:Fakultní nemocnice Ostrava
    Full Title: Pilot, monocentre, phase-IV clnical trial assessing the clinical effect of per oral immunomodulation treatment using the IMUNOR® preparation in the prevention of COVID-19 disease
    Medical condition: COVID-19 prevention
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-004849-33 Sponsor Protocol Number: Asp-Fam-01 Start Date*: 2005-12-21
    Sponsor Name:NHS Greater Glasgow
    Full Title: Prevention of oesophagitis, gastric and duodenal lesions in patients taking antithrombotic low-dose aspirin with famotidine
    Medical condition: Peptic ulceration induced by low-dose aspirin
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-004789-20 Sponsor Protocol Number: GDW07/08 Start Date*: 2008-09-05
    Sponsor Name:UZLEUVEN
    Full Title: ” A comparative double-blind placebo-controlled study between alizapride and ondansetron for the prevention of postoperative nausea and vomiting.”
    Medical condition: Prevention of post-operative nausea and vomiting.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-002293-44 Sponsor Protocol Number: PRAKYFRA-01 Start Date*: 2018-07-25
    Sponsor Name:VIFOR FRANCE
    Full Title: A Pragmatic randomized study to evaluate the comparative effectiveness of Akynzeo® and Standard of care (including Emend®) for the prevention of nausea and vomiting (CINV) in cancer patients receiv...
    Medical condition: prevention of nausea and vomiting in cancer patients receiving moderately emetogenic chemotherapy
    Disease: Version SOC Term Classification Code Term Level
    20.1 10042613 - Surgical and medical procedures 10054133 Prophylaxis of nausea and vomiting PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000970-10 Sponsor Protocol Number: LPS16140 Start Date*: 2020-09-09
    Sponsor Name:Sanofi Aventis Groupe
    Full Title: Phase III, randomized, double blind, parallel groups, clinical trial to evaluate the efficacy and safety of Bacillus clausii versus placebo in the prevention of antibiotic associated diarrhea (AAD)...
    Medical condition: Antibiotic associated diarrhea (AAD) in children
    Disease: Version SOC Term Classification Code Term Level
    21.0 10042613 - Surgical and medical procedures 10064065 Prophylaxis against diarrhoea PT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-002898-19 Sponsor Protocol Number: IndiviStat#1 Start Date*: 2018-01-08
    Sponsor Name:Helsinki University Central Hospital
    Full Title: There is no English name for the trial.
    Medical condition: Primary prevention of atherosclerotic disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-019947-21 Sponsor Protocol Number: MIGRAPED01 Start Date*: 2011-08-30
    Sponsor Name:CAIBER
    Full Title: Phase III study, multicenter, randomized, double-blind, parallel group measuring the efficacy and safety of flunarizine in the prevention of migraine in the pediatric population.
    Medical condition: Prevention of migraine attacks in pediatric population.
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-001988-21 Sponsor Protocol Number: 1160.48 Start Date*: 2004-11-01
    Sponsor Name:Boehringer Ingelheim Finland Ky
    Full Title: A phase III randomised, parallel group, double-blind, active controlled study to investigate the efficacy and safety of two different dose regimens of orally administered dabigatran etexilate capsu...
    Medical condition: Prevention of venous thromboembolism following primary elective total hip replacement surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Completed) AT (Completed) DE (Completed) HU (Completed) DK (Completed) CZ (Completed) IT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2004-001317-34 Sponsor Protocol Number: 1160.25 Start Date*: 2004-11-01
    Sponsor Name:Boehringer Ingelheim Finland Ky
    Full Title: A phase III, randomised, parallel-group, double-blind, active controlled study to investigate the efficacy and safety of two different dose regimens of orally administered dabigatran etexilate caps...
    Medical condition: Prevention of venous thromboembolism following primary elective total knee replacement surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Completed) DE (Completed) AT (Completed) HU (Completed) DK (Completed) CZ (Completed) IT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-001706-34 Sponsor Protocol Number: D5470C00004 Start Date*: 2016-03-07
    Sponsor Name:MedImmune, LLC
    Full Title: A Phase 2 Proof-of-concept Study to Evaluate the Efficacy and Safety of MEDI3902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginosa.
    Medical condition: Prevention of nosocomial pneumonia caused by Pseudomonas aeruginosa
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004862 10051190 Pneumonia Pseudomonas aeruginosa LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) CZ (Completed) HU (Completed) DE (Prematurely Ended) BE (Completed) GR (Completed) PT (Completed) HR (Completed) AT (Completed) SK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-004494-96 Sponsor Protocol Number: BAY 59-7939/IMP 11899 Start Date*: 2007-03-19
    Sponsor Name:Bayer HealthCare AG
    Full Title: Once-daily oral direct factor Xa inhibitor rivaroxaban in the long-term prevention of recurrent symptomatic venous thromboembolism in patients with symptomatic deep-vein thrombosis or pulmonary emb...
    Medical condition: Long-term prevention of recurrent symptomatic venous thromboembolism in patients with symptomatic deep-vein thrombosis or pulmonary embolism.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) ES (Completed) SE (Completed) DE (Completed) FI (Completed) FR (Completed) HU (Completed) AT (Completed) IT (Completed) DK (Completed) CZ (Completed) NL (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-001370-28 Sponsor Protocol Number: Jens1 Start Date*: 2012-10-30
    Sponsor Name:Afdeling Urologie, Isala Klinieken
    Full Title: Pain treatment in renal colics; the role of Instanyl ® in prevention of hospitalization. A double-blinded, randomized, placebo-controlled trial.
    Medical condition: Renal colic
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002082-13 Sponsor Protocol Number: BUF-17/RAP Start Date*: 2008-07-09
    Sponsor Name:Dr. Falk Pharma GmbH
    Full Title: Randomised, double-blind, placebo-controlled, multicentre, comparative phase II pilot study on the efficacy and tolerability of an 8-week rectal treatment with 2 mg budesonide or placebo for the pr...
    Medical condition: prevention of acute radiation proctitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10037766 Radiation proctitis LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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