The following updates were made: [1] The Roche Medical Responsible was identified as the Roche Medical Monitor; [2] Descriptions of the roles and responsibilities on the Internal Monitoring Committee were added; [3] Requirements for re-screening were added and/or clarified; [4] Eligibility requirement for woman of childbearing potential to refrain from donating eggs was added; [5] Text clarifying that the eligibility requirements for men refraining from donating sperm were added; [6] Text identifying acetaminophen as CYP1A2 was added to clarify its interaction with vemurafenib; [7] Text describing and allowing screening window extensions was added; [8] Text describing Next-generation sequencing of study participant samples was revised; [9] Timing of destruction of samples collected from participants who have not consented to optional donation was modified; [10] Nephritis was added as a known risk to be associated with atezolizumab; [11] The length of time atezolizumab treatment was suspended was revised; [12] Submission of tumor tissue biomarker analyses was moved from screening to Cycle 1, Day 1; [13] [9] Additional minor changes were made to improve clarity and consistency.

The following updates were made: [1] The Sponsor communicated the decision to discontinue enrollment in Cohort 1 in a Dear Investigator Letter dated 9 July 2019; [2] Benefit-Risk assessment was updated; [3] Sample size calculations were revised; [4] Primary efficacy analysis was revised to only include participants enrolled in Cohort 2; [5] Intracranial ORR as assessed by the investigator according to RECIST v1.1 was added as a secondary efficacy endpoint; [6] Inclusion criteria was revised; [7] Study Treatment Dosage for Cohort 1 was updated; [8] Permitted Therapy section was updated; [9] Guidelines for managing patients who experienced atezolizumab-associated adverse events were revised; [10] Management Guidelines for Cohort 1 and Emergency Medical Contacts were updated; [11] Abortions section was revise to clarify new safety reporting requirements; [12] Immune-related was changed to 'immune-mediated' throughout the protocol; [13] Additional minor changes were made to improve the clarity and consistency.

The following updates were made: [1] The definition of the endpoint of intracranial ORR by investigator was clarified to align with the IRC-determined definition; [2] Proteinuria inclusion criteria was removed; [3] The rationale for the dose of atezolizumab was updated; [4] Clarity was introduced on the recommendation for vemurafenib interruption in the event of planned stereotactic radiotherapy; [5] Clarification that intracranial and extracranial tumour assessments do not need to be done for study purposes; [6] In the event of disease progression, a confirmatory tumour assessment was to be performed approximately four weeks later; [7] Added "Management of Study Quality" section and updated the "Publication of Data and Protection of Trade Secrets" section; [8] Safety updates from the atezolizumab Investigator's Brochure were added; [9] Additional minor changes were made to improve clarity and consistency.

The following updates were made: [1] List of approved indications for atezolizumab was updated; [2] Provisions related to performing the study in the setting of the coronavirus disease 2019 (COVID-19) pandemic were added; [3] Benefit-risk assessment and guidance on concomitant administration of COVID-19 vaccines with atezolizumab was added; [4] AE management guidelines were updated; [5] The responsibilities of the investigator and the role of the Medical Monitor were clarified; [6] Language was added to indicate that sites could confirm that appropriate temperature conditions were maintained during investigational medicinal product (IMP) transit; [7] Immunosuppressive medications have been removed from the prohibited therapy section and added to the cautionary therapy section; [8] Updates related to the risks associated with atezolizumab; [9] Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) replaced systemic inflammatory response syndrome on the list of atezolizumab-associated adverse events ofspecial interest (AESI); [10] Language was added to the ICF to instruct female participants to inform the investigator if they became pregnant; [11] language regarding investigator reporting of pregnancies was clarified; [12] Management guidelines for Grade 4 myositis were removed; [13] The management guidelines for HLH and MAS have been modified to indicate that HLH were to be considered when CRS presentation was atypical or prolonged, to add anticytokine therapy as an option for treating HLH or MAS, and suggest that published guidelines be followed for HLH or MAS events that did not respond to treatment within 24 hours; [14] Minor updates to the management guidelines for Suspected Hemophagocytic Lymphohistiocytosis or Macrophage Activation Syndrome; [15] The medical term “primary biliary cirrhosis” was replaced by the term “primary biliary cholangitis;” [16] Additional minor changes were made to improve clarity and consistency.