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Clinical trials for methylphenidate hydrochloride

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    44 result(s) found for: methylphenidate hydrochloride. Displaying page 1 of 3.
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    EudraCT Number: 2010-023992-24 Sponsor Protocol Number: MEMAP1 Start Date*: 2011-08-26
    Sponsor Name:University of Leipzig
    Full Title: International randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Medical condition: acute mania and hypomania (ICD-10: F30.0, F30.1, F31.0, F31.1)
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004873 10000852 Acute mania LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Prematurely Ended) BE (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2012-003418-15 Sponsor Protocol Number: SSP Start Date*: 2012-10-23
    Sponsor Name:Medizinische Universität Wien
    Full Title: Methylphenidate modified release as treatment option of MS-associated fatigue. A single-center randomized double-blind placebo-controlled trial.
    Medical condition: Fatigue is a very common symptom in multiple sclerosis. Its management comprises nonpharmacologic approaches like exercise, cooling procedures and energy conservation programs and as second step ph...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-001950-33 Sponsor Protocol Number: 15/0592 Start Date*: 2018-01-19
    Sponsor Name:UCL
    Full Title: Methylphenidate versus placebo for fatigue in advanced cancer (MePFAC)
    Medical condition: Cancer-related fatigue
    Disease: Version SOC Term Classification Code Term Level
    20.0 10018065 - General disorders and administration site conditions 10016256 Fatigue PT
    Population Age: Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2004-000502-40 Sponsor Protocol Number: RHM CAN0380 Start Date*: 2005-05-13
    Sponsor Name:Southampton University Hospitals Trust
    Full Title: A thematic analysis of semi-structured interviews using a phenomenological approach into palliative care patients experiences of change in "fatigue" following treatment with methylphenidate – an ex...
    Medical condition: Patients with cancer in palliative stage of their illness. Suffering from fatigue with or without decreased concentration, depression or drowsiness, who feel their fatigue is severe enough to decre...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-012643-42 Sponsor Protocol Number: 28119 Start Date*: 2010-01-06
    Sponsor Name:University Medical Center Groningen
    Full Title: Freezing of gait in Parkinson's disease: in search of the underlying mechanism and the application of a new treatment option
    Medical condition: Parkinson's disease, in particular the symptom Freezing of Gait
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005073-28 Sponsor Protocol Number: ParKMetil/001 Start Date*: 2021-12-28
    Sponsor Name:Universidad Rey Juan Carlos
    Full Title: Double-blind, randomized, crossover design for evaluation of efficacy and safety of methylphenidate in cognition in patients with Parkinson's disease using electrophysiological measures
    Medical condition: Cognition
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-004815-22 Sponsor Protocol Number: INDICES/WP2/01 Start Date*: 2012-01-24
    Sponsor Name:Research Institute of Biological Psychiatry Sct. Hans
    Full Title: Individualised drug therapy based on pharmacogenomics: focus on carboxylesterase 1 (CES1)
    Medical condition: Healthy volunteers with special genotypes
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004848 10053349 Pharmacokinetic study LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2008-003285-26 Sponsor Protocol Number: ASTA Start Date*: Information not available in EudraCT
    Sponsor Name:Universität Mainz, Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie
    Full Title: Effect of methylphenidate formulation on ADHD-patients' adherence to medical treatment. A comparison of Medikinet retard® (ER) once daily and Medikinet® (IR) twice daily in children and adolescents...
    Medical condition: Effect of methylphenidate formulation on ADHD-patients adherence to treatment
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064104 ADHD LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-000992-18 Sponsor Protocol Number: 12-016 Start Date*: 2014-09-26
    Sponsor Name:UMC Utrecht
    Full Title: Proactive versus reactive inhibition in ADHD: Genetics, neurobiology and pharmacology
    Medical condition: Attention-Deficit Hyperactivity Disorder (ADHD)
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-000492-17 Sponsor Protocol Number: NL39440.029.10 Start Date*: 2012-10-29
    Sponsor Name:Afdeling Klinische Neuropsychologie Vrije Universiteit Amsterdam
    Full Title: The Effects of Long-acting Methylphenidate on Academic Activity and Related Constructs in Children with ADHD: A Randomised Placebo Controlled Trial
    Medical condition: Attention-deficit hyperactivity disorder (ADHD)
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-000730-37 Sponsor Protocol Number: 42603ATT3002 Start Date*: 2005-02-07
    Sponsor Name:Janssen-Cilag Medical Affairs EMEA
    Full Title: A multicentre, randomised, double-blind, placebo-controlled, parallel group, dose-response phase III A study to evaluate safety and efficacy of Prolonged Release (PR) OROS methylphenidate (18, 36 a...
    Medical condition: Attention Deficit Hyperactivity Disorder (ADHD)
    Disease: Version SOC Term Classification Code Term Level
    10003731
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) DK (Completed) CZ (Completed) FI (Completed)
    Trial results: View results
    EudraCT Number: 2021-001453-31 Sponsor Protocol Number: CONMED3 Start Date*: Information not available in EudraCT
    Sponsor Name:Copenhagen University Hospital Rigshospitalet
    Full Title: Automated pupillometry and NIRS-EEG to detect signatures of consciousness in acute brain injury after apomorphine and methylphenidate stimulation: A placebo-controlled, randomized, cross-over study
    Medical condition: We investigate the possible effects of commercially available apomorphine and methylphenidate on signatures of consciousness in patients admitted to the ICU with acute disorder of consciousness, us...
    Disease: Version SOC Term Classification Code Term Level
    25.1 10029205 - Nervous system disorders 10013509 Disturbances in consciousness NEC HLT
    21.1 10029205 - Nervous system disorders 10067967 Brain injury PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-002897-31 Sponsor Protocol Number: 1453 Start Date*: 2006-04-04
    Sponsor Name:North Bristol NHS Trust
    Full Title: Objective assessment of attention difficulties in adults with Attention-Deficit Hyperactivity Disorder (ADHD)
    Medical condition: Attention-Deficit Hyperactivity Disorder (ADHD) in Adults
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-003882-17 Sponsor Protocol Number: MKM Start Date*: 2013-05-06
    Sponsor Name:Charité Universitaetsmedizin Berlin
    Full Title: Effects of modafinil, caffeine and methylphenidate on functional brain activity and cognitive performance in healthy subjects: a randomized, placebo-controlled, double-blind fMRI study.
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2007-002111-82 Sponsor Protocol Number: 42603ATT3013 Start Date*: 2007-10-24
    Sponsor Name:Janssen-Cilag International N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Response Study to Evaluate Efficacy and Safety of Prolonged Release (PR) OROS® methylphenidate (54 and 72 mg/day) i...
    Medical condition: Attention Deficit-Hyperactivity Disorder (ADHD)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003735 Attention deficit-hyperactivity disorder LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed) SE (Completed) NL (Completed) DK (Completed) FI (Completed) BE (Completed) GB (Completed) ES (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-004037-18 Sponsor Protocol Number: 42603ATT3004 Start Date*: 2006-03-10
    Sponsor Name:Janssen-Cilag Medical Affairs EMEA
    Full Title: An Open Label, Multicentre Study to Evaluate the Long Term Safety of Prolonged Release (PR) OROS Methylphenidate (18, 36, 54, 72 and 90 mg/day) in Adults with Attention Deficit/Hyperactivity Disor...
    Medical condition: Attention Deficit-Hyperactivity Disorder (ADHD)
    Disease: Version SOC Term Classification Code Term Level
    7.1 10003735 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) PT (Completed)
    Trial results: View results
    EudraCT Number: 2009-011426-33 Sponsor Protocol Number: B4Z-EW-LYEN Start Date*: 2009-10-13
    Sponsor Name:Lilly S.A.
    Full Title: “Evaluación del Efecto de las Dosis Omitidas (Días Off) de la Medicación Diaria en Pacientes con una Farmacoterapia Estable para el TDAH Recibiendo Atomoxetina o Metilfenidato OROS: Un Estudio Clín...
    Medical condition: Trastorno por Deficit de Atencion-Hiperactividad (TDAH)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064104 ADHD LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) NL (Completed) SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-001070-18 Sponsor Protocol Number: 42603ATT4040 Start Date*: 2015-04-24
    Sponsor Name:Janssen-Cilag Taiwan
    Full Title: The Effective and Tolerable Titration Scheme and Dosage in Children with Attention-deficit hyperactivity disorder Treated with OROS-Methylphenidate
    Medical condition: Attention Deficit Hyperactivity Disorder
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004873 10003735 Attention deficit-hyperactivity disorder LLT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2007-003965-42 Sponsor Protocol Number: 002 Start Date*: 2007-12-04
    Sponsor Name:University Medical Centre Utrecht
    Full Title: Methylphenidate, rivastigmine or haloperidol in hypoactive delirious intensive care patients: a single centre, randomized, mono-blind pilot trial
    Medical condition: Hypoactive delirious ICU-patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012218 Delirium LLT
    9.1 10012218 Delirium PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-002171-94 Sponsor Protocol Number: Newrofeed Start Date*: 2016-10-20
    Sponsor Name:Mensia Technologies SA
    Full Title: Effectiveness of a personalized Neurofeedback Training device (ADHD@Home) as compared with Methylphenidate in the treatment of children and adolescents with Attention-Deficit/Hyperactivity Disorder...
    Medical condition: Attention Deficit-Hyperactivity Disorder
    Disease: Version SOC Term Classification Code Term Level
    19.0 10037175 - Psychiatric disorders 10003736 Attention deficit/hyperactivity disorder PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Completed) BE (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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