interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development
EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).
The EU Clinical Trials Register currently displays
44341
clinical trials with a EudraCT protocol, of which
7370
are clinical trials conducted with subjects less than 18 years old.
The register also displays information on
18700
older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see
Frequently Asked Questions ).
Full Title: Phase 1/2a, first-in-human, open-label, dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of CLDN6 CAR-T with or without CLDN6 RNA-LPX in patients with CLDN6-...
Medical condition: CLDN6-positive relapsed or refractory advanced solid tumors
Disease:
Version
SOC Term
Classification Code
Term
Level
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10043302
Testicular cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033128
Ovarian cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10017758
Gastric cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10046766
Uterine cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10007460
Carcinoma of unknown primary
LLT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10065147
Malignant solid tumor
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:DE(Trial now transitioned)NL(Trial now transitioned)SE(Trial now transitioned)
Trial results:(No results available)
EudraCT Number: 2018-003974-29
Sponsor Protocol Number: D6186C00001
Start Date*: 2019-08-15
Sponsor Name:AstraZeneca AB
Full Title: A Biomarker-Directed Phase 2 Platform Study in Patients with Advanced Non-Small Cell Lung Cancer whose Disease has Progressed on First-Line Osimertinib Therapy
Medical condition: Advanced Non-Small Cell Lung Cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:SE(Trial now transitioned)NO(Trial now transitioned)DK(Completed)ES(Ongoing)NL(Trial now transitioned)IT(Trial now transitioned)
Trial results:(No results available)
EudraCT Number: 2022-001843-25
Sponsor Protocol Number: BNT141-01
Start Date*: 2023-02-23
Sponsor Name:BioNTech SE
Full Title: Phase I/IIa, first-in-human, open-label, dose escalation trial with expansion cohorts to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of BNT141 as a monotherapy and...
Medical condition: CLDN18.2-positive solid tumors
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10065252
Solid tumor
LLT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10017758
Gastric cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10066354
Adenocarcinoma of the gastroesophageal junction
LLT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10015332
Esophageal adenocarcinoma recurrent
LLT
21.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10033604
Pancreatic cancer
LLT
20.0
100000004871
10004676
Biliary tract disease
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008593
Cholangiocarcinoma
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase 3, Randomized, Placebo-Controlled, Double-Blinded, Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with C3 Glomerulopathy or Immune-Complex Membranoprolif...
Medical condition: complement 3 glomerulopathy (C3G)/immune complex membranoproliferative glomerulonephritis (IC-MPGN)
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10038359 - Renal and urinary disorders
10038359
Renal and urinary disorders
SOC
20.0
10038359 - Renal and urinary disorders
10077827
C3 glomerulopathy
PT
21.1
10038359 - Renal and urinary disorders
10027168
Membranoproliferative glomerulonephritis
LLT
Population Age: Adolescents, Under 18, Adults, Elderly
Gender: Male, Female
Trial protocol:DE(Trial now transitioned)NL(Trial now transitioned)CZ(Completed)BE(Completed)AT(Trial now transitioned)FR(Completed)PL(Completed)IT(Trial now transitioned)ES(Ongoing)
Trial results:(No results available)
EudraCT Number: 2018-002261-19
Sponsor Protocol Number: PRN1008-012
Start Date*: 2018-12-12
Sponsor Name:Principia Biopharma
Full Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Oral BTK Inhibitor PRN1008 in Moderate to Severe Pemphigus
Medical condition: pemphigus vulgaris [PV] or pemphigus foliaceus [PF]
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
100000004858
10052802
Pemphigus vulgaris
LLT
21.0
100000004858
10057054
Pemphigus foliaceous
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:BG(Prematurely Ended)FR(Prematurely Ended)DE(Prematurely Ended)GB(GB - no longer in EU/EEA)ES(Ongoing)GR(Completed)HR(Completed)IT(Prematurely Ended)
Full Title: Ensayo abierto, aleatorizado, de dos años de duración, en el que se comparan dos regímenes de primera línea en sujetos infectados por el VIH que no han recibido tratamiento antirretroviral previo: ...
Medical condition: Infección por el virus de la inmunodeficiencia humana
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• EEA CTAs: Date study was authorised to proceed • Outside EU/EEA: Date study was submitted in EudraCT