Clinical trials

The European Union Clinical Trials Register allows you to search for protocol and results information on:

interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC

clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).

The EU Clinical Trials Register currently displays 44352 clinical trials with a EudraCT protocol, of which 7379 are clinical trials conducted with subjects less than 18 years old. The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).

Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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Trials with a EudraCT protocol (44,352)
Paediatric studies in scope of Art45 of the Paediatric Regulation (18,700)

44,352 result(s) found. Displaying page 195 of 2,218.

EudraCT Number: 2010-021156-26

Sponsor Protocol Number: VX10-950-022

Start Date*: 2012-02-17

Sponsor Name:Vertex Pharmaceuticals Inc.

Full Title: A Phase 1, Randomized, Open-label, Single-Dose, Crossover, Relative Bioavailability, and Food-Effect Study of a Pediatric Chewable Tablet Formulation Relative to a 375-mg Core Tablet Formulation of...

Medical condition: chronic hepatitis c virus genotype 1 infection

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	14.1	10021881 - Infections and infestations	10008912	Chronic hepatitis C	LLT

Population Age: Adults

Gender: Male, Female

Trial protocol: Outside EU/EEA

Trial results: View results

EudraCT Number: 2010-021174-11

Sponsor Protocol Number: TMC435-TiDP16-C216

Start Date*: 2011-01-12

Sponsor Name:Tibotec Pharmaceuticals

Full Title: Estudio en fase III, aleatorizado, doble ciego y controlado con placebo para investigar la eficacia, la seguridad y la tolerabilidad de TMC435 frente a placebo como parte de un régimen de tratamien...

Medical condition: Hepatitis C Virus (HCV) in treatment naïve patients Infección por el virus de la hepatitis C (VHC) en pacientes que no han recibido nunca tratmiento

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	12.1		10019752	Hepatitis C virus (HCV)	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: ES (Completed) DE (Completed) PT (Completed) BE (Completed) SK (Completed) AT (Completed) PL (Completed) BG (Completed)

Trial results: View results

EudraCT Number: 2010-022123-29

Sponsor Protocol Number: ASA-COPD

Start Date*: 2010-11-25

Sponsor Name:Medical University of Vienna, Department of Clinical Pharmacology

Full Title: Acetylic salicylic acid for the treatment of Chronic Obstructive Pulmonary Disease (COPD). A randomized, double-blind, placebo-controlled trial

Medical condition: COPD II-III

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	13.1	10038738 - Respiratory, thoracic and mediastinal disorders	10010952	COPD	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: AT (Prematurely Ended)

Trial results: View results

EudraCT Number: 2010-018791-24

Sponsor Protocol Number: KM003EPC

Start Date*: 2011-07-04

Sponsor Name:Kliniken der Stadt Koeln gGmbH, Klinikum Merheim

Full Title: Single-center, single-armed, open-label, prospective study assessing efficacy and safety of a conversion of stable kidney allograft recipients to an Everolimus-based regimen to prevent the developm...

Medical condition: This study is designed to assess whether a conversion from a CNI-based therapy to a CNI-free therapy with Certican® in stable renal transplant patients is able to prevent the development of Chronic...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	12.1		10023438	Kidney transplant	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Ongoing)

Trial results: (No results available)

EudraCT Number: 2008-005013-21

Sponsor Protocol Number: EMR 62202-811

Start Date*: 2009-01-23

Sponsor Name:Institut de Cancérologie de la Loire

Full Title: ERBITUX

Medical condition: Locally advanced non small cell lung cancer

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10025053	Lung cancer non-small cell stage IIIA	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: FR (Ongoing)

Trial results: (No results available)

EudraCT Number: 2009-016992-31

Sponsor Protocol Number: COU-001A

Start Date*: 2010-03-19

Sponsor Name:Democritus Universityof Thrace Medical School [...]

Full Title: EUropean Pharmacogenetics of AntiCoagulation Therapy trial

Medical condition: Newly diagnosed patients with venous tromboembolism (VTE) or atrial fibrillation (AF) requiring oral anticoagulation with phenprocoumon.

Disease:	Version	SOC Term	Classification Code	Term	Level
	12.1		10003658	Atrial fibrillation	LLT
	12.1		10012107	Deep venous thrombosis NOS	LLT
	12.1		10037377	Pulmonary embolism	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: NL (Ongoing)

Trial results: (No results available)

EudraCT Number: 2009-017010-68

Sponsor Protocol Number: 1235.34

Start Date*: 2010-07-21

Sponsor Name:Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Full Title: A TElmisartan and AMlodipine STudy to Assess the cardiovascular PROTECTive effects as measured by endothelial dysfunction in hypertensive at risk patients beyond blood pressure

Medical condition:  Male and female, treated and treatment-naive patients with uncontrolled hypertension (defined as 20/10 mmHg above target BP of <140/90 mmHg [<130/80 mmHg for renally impaired and/ or diabetics pa...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	13.1	10047065 - Vascular disorders	10020772	Hypertension	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Completed)

Trial results: (No results available)

EudraCT Number: 2009-016608-22	Sponsor Protocol Number: PHRCIR09-DrTOURNEUX	Start Date*: 2010-01-27
Sponsor Name:CHU AMIENS
Full Title: Administration de Surfactant précoce : Evaluation chez le Nouveau-né ≥ 35 semaines d’aménorrhée présentant une détresse respiratoire
Medical condition: Détresse respiratoire du nouveau-né entre 35 et 41 semaines d'aménorrhées
Disease:
Population Age: Preterm newborn infants, Newborns, Under 18		Gender: Male, Female
Trial protocol: FR (Ongoing)
Trial results: (No results available)

EudraCT Number: 2008-008045-38

Sponsor Protocol Number: SS-BEL-01

Start Date*: 2009-06-23

Sponsor Name:AZIENDA OSPEDALIERA S. MARIA DELLA MISERICORDIA

Full Title: A Phase 2, proof of concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects with primary Sjög...

Medical condition: Subjects with have a diagnosis of primary SS according to the updated American European Consensus Group Criteria (8). In addition, patients must be always positive for anti-SSA or anti-SSB antibod...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10021428		SOC

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: IT (Ongoing)

Trial results: (No results available)

EudraCT Number: 2008-003207-30

Sponsor Protocol Number: CICL670AES04

Start Date*: 2008-10-01

Sponsor Name:NOVARTIS FARMACEUTICA S.A

Full Title: Ensayo abierto, no aleatorizado, multicéntrico, que evalúa la eficacia y seguridad de deferasirox (Exjade®) en pacientes con sobrecarga férrica después de un trasplante alogénico de progenitores he...

Medical condition: Pacientes que presenten evidencia de sobrecarga férrica (ferritina sérica ≥1000 ng/ml) entre 6 y 18 meses después de un TPH alogénico (independientemente de la enfermedad subyacente y del ré...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10065973		LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: ES (Completed)

Trial results: View results

EudraCT Number: 2009-011257-40

Sponsor Protocol Number: CgA

Start Date*: 2009-06-05

Sponsor Name:AZIENDA OSPEDALIERA S. LUIGI GONZAGA

Full Title: Sospension of androgen hormonal deprivation in patients with high levels of CgA

Medical condition: Cancer histologic diagnosis of prostatic carcinoma in hormonal escape

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10018187	Genitourinary neoplasms malignancy and gender unspecified	HLT

Population Age: Adults, Elderly

Gender: Male

Trial protocol: IT (Prematurely Ended)

Trial results: (No results available)

EudraCT Number: 2010-020439-38

Sponsor Protocol Number: GEICO-1002

Start Date*: 2010-09-21

Sponsor Name:Grupo Español de Investigación en Cáncer de Ovario (GEICO)

Full Title: Ensayo clínico fase II no controlado, multicéntrico y prospectivo para determinar el beneficio clínico y toxicidad de Pazopanib, inhibidor multidiana de receptores con actividad tirosin-quinasa (VE...

Medical condition: Cáncer de ovario avanzado resistente a platino

Disease:	Version	SOC Term	Classification Code	Term	Level
	13		10026310	Neoplasia maligna de ovario	LLT
	13		10007107	Cáncer de ovario	LLT

Population Age: Adults, Elderly

Gender: Female

Trial protocol: ES (Ongoing)

Trial results: (No results available)

EudraCT Number: 2010-020447-13

Sponsor Protocol Number: CRAD001L2404

Start Date*: 2012-08-17

Sponsor Name:Novartis Pharma Services AG

Full Title: An open-label, multicenter phase II study to examine the efficacy and safety of everolimus as second-line therapy in the treatment of patients with metastatic renal cell carcinoma

Medical condition: Metastatic Renal Cell Carcinoma

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	17.0	10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)	10050513	Metastatic renal cell carcinoma	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: BG (Completed)

Trial results: View results

EudraCT Number: 2009-010998-20

Sponsor Protocol Number: HM09/8848

Start Date*: 2009-06-25

Sponsor Name:Leeds Teaching Hospitals NHS Trust

Full Title: Attenuated dose Rituximab with ChemoTherapy In CLL: A randomised, phase IIB trial in previously untreated patients with Chronic Lymphocytic Leukaemia (CLL) to compare fludarabine, cyclophosphamide ...

Medical condition: Chronic Lymphocytic Leukaemia

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	13.1	10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)	10008958	Chronic lymphocytic leukaemia	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (GB - no longer in EU/EEA)

Trial results: (No results available)

EudraCT Number: 2008-005033-29	Sponsor Protocol Number: CT/08.22	Start Date*: 2009-07-20
Sponsor Name:Vassilis Georgoulias, Prof. of Internal Medicine-Oncology of Medical Dpt University of Crete
Full Title: A PHASE II STUDY OF sunitinib IN PATIENTS WITH ADVANCED HORMONE RESISTANT AND CHEMOTHERAPY RESISTANT PROSTATE CANCER.
Medical condition: Patients with advanced hormone resistant and chemotherapy resistant prostate cancer.
Disease:
Population Age: Adults, Elderly		Gender: Male
Trial protocol: GR (Prematurely Ended)
Trial results: (No results available)

EudraCT Number: 2008-005046-23

Sponsor Protocol Number: POL 2

Start Date*: 2009-03-23

Sponsor Name:Polyphor AG

Full Title: A Phase IIa, Proof of Concept Study to Determine the Degree of Mobilisation of CD34+ Cells Following Administration of POL6326 in Patients with Multiple Myeloma

Medical condition: Multiple Myeloma

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10028228	Multiple myeloma	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Restarted)

Trial results: (No results available)

EudraCT Number: 2008-002855-26	Sponsor Protocol Number: Droxidopa-301	Start Date*: 2008-10-01
Sponsor Name:Chelsea Therapeutics Inc
Full Title: A Multi-Centre, Double-Blind, Placebo-Controlled, Parallel-Group Induction-Design Study to assess the Clinical Effect of Droxidopa in Subjects with Primary Autonomic Failure, Dopamine Beta Hydroxyl...
Medical condition: Symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure (Pharmacodynamic, MSA and PAF), DBH deficiency and Non-Diabetic Neuropathy.
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: DE (Completed) AT (Completed) CZ (Completed) IT (Completed)
Trial results: View results

EudraCT Number: 2004-005050-31	Sponsor Protocol Number: IR103-112	Start Date*: 2005-07-21
Sponsor Name:THE IMMUNE RESPONSE CORPORATION
Full Title: A safety and Immunogenicity Study of IR103 HIV-1 Antigen plus Amplivax TM in IFA Comapared to Remune R HIV-1 antigen in IFA in Antiretroviral Naive HIV-1 Infected Subjects
Medical condition: agent able to generate HIV-specific immune responses in antiretroviral naive HIV infected subjects.
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: IT (Prematurely Ended)
Trial results: (No results available)

EudraCT Number: 2004-005055-33

Sponsor Protocol Number: ML17443

Start Date*: 2005-09-01

Sponsor Name:Barts and the London NHS Trust

Full Title: Evaluating the safety and efficacy of mycophenolate mofetil, daclizumab and a single, initial week of corticosteroids in combination with tacrolimus or sirolimus with continued steroid as mainstay ...

Medical condition: Renal Transplantation

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	7.1		10038533		PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (Prematurely Ended)

Trial results: View results

EudraCT Number: 2009-012602-39

Sponsor Protocol Number: 05-NEOV-002

Start Date*: 2010-05-17

Sponsor Name:Fresenius Kabi Deutschland GmbH

Full Title: A randomised, double-blind study evaluating the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact(R) in premature very low bir...

Medical condition: The product is aimed to be used where parenteral nutrition is required. The intended indication is: Supply of essential and non-essential amino acids as part of parenteral nutrition for premature ...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	12.1		10051284	Parenteral nutrition	LLT

Population Age: Preterm newborn infants, Under 18

Gender: Male, Female

Trial protocol: DE (Prematurely Ended) NL (Prematurely Ended)

Trial results: View results

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The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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