Clinical trials

The European Union Clinical Trials Register allows you to search for protocol and results information on:

interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC

clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).

The EU Clinical Trials Register currently displays 44380 clinical trials with a EudraCT protocol, of which 7392 are clinical trials conducted with subjects less than 18 years old. The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).

Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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Trials with a EudraCT protocol (44,380)
Paediatric studies in scope of Art45 of the Paediatric Regulation (18,700)

44,380 result(s) found. Displaying page 195 of 2,219.

EudraCT Number: 2010-020447-13

Sponsor Protocol Number: CRAD001L2404

Start Date*: 2012-08-17

Sponsor Name:Novartis Pharma Services AG

Full Title: An open-label, multicenter phase II study to examine the efficacy and safety of everolimus as second-line therapy in the treatment of patients with metastatic renal cell carcinoma

Medical condition: Metastatic Renal Cell Carcinoma

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	17.0	10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)	10050513	Metastatic renal cell carcinoma	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: BG (Completed)

Trial results: View results

EudraCT Number: 2009-010998-20

Sponsor Protocol Number: HM09/8848

Start Date*: 2009-06-25

Sponsor Name:Leeds Teaching Hospitals NHS Trust

Full Title: Attenuated dose Rituximab with ChemoTherapy In CLL: A randomised, phase IIB trial in previously untreated patients with Chronic Lymphocytic Leukaemia (CLL) to compare fludarabine, cyclophosphamide ...

Medical condition: Chronic Lymphocytic Leukaemia

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	13.1	10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)	10008958	Chronic lymphocytic leukaemia	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (GB - no longer in EU/EEA)

Trial results: (No results available)

EudraCT Number: 2008-005033-29	Sponsor Protocol Number: CT/08.22	Start Date*: 2009-07-20
Sponsor Name:Vassilis Georgoulias, Prof. of Internal Medicine-Oncology of Medical Dpt University of Crete
Full Title: A PHASE II STUDY OF sunitinib IN PATIENTS WITH ADVANCED HORMONE RESISTANT AND CHEMOTHERAPY RESISTANT PROSTATE CANCER.
Medical condition: Patients with advanced hormone resistant and chemotherapy resistant prostate cancer.
Disease:
Population Age: Adults, Elderly		Gender: Male
Trial protocol: GR (Prematurely Ended)
Trial results: (No results available)

EudraCT Number: 2008-005046-23

Sponsor Protocol Number: POL 2

Start Date*: 2009-03-23

Sponsor Name:Polyphor AG

Full Title: A Phase IIa, Proof of Concept Study to Determine the Degree of Mobilisation of CD34+ Cells Following Administration of POL6326 in Patients with Multiple Myeloma

Medical condition: Multiple Myeloma

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10028228	Multiple myeloma	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Restarted)

Trial results: (No results available)

EudraCT Number: 2008-002855-26	Sponsor Protocol Number: Droxidopa-301	Start Date*: 2008-10-01
Sponsor Name:Chelsea Therapeutics Inc
Full Title: A Multi-Centre, Double-Blind, Placebo-Controlled, Parallel-Group Induction-Design Study to assess the Clinical Effect of Droxidopa in Subjects with Primary Autonomic Failure, Dopamine Beta Hydroxyl...
Medical condition: Symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure (Pharmacodynamic, MSA and PAF), DBH deficiency and Non-Diabetic Neuropathy.
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: DE (Completed) AT (Completed) CZ (Completed) IT (Completed)
Trial results: View results

EudraCT Number: 2004-005050-31	Sponsor Protocol Number: IR103-112	Start Date*: 2005-07-21
Sponsor Name:THE IMMUNE RESPONSE CORPORATION
Full Title: A safety and Immunogenicity Study of IR103 HIV-1 Antigen plus Amplivax TM in IFA Comapared to Remune R HIV-1 antigen in IFA in Antiretroviral Naive HIV-1 Infected Subjects
Medical condition: agent able to generate HIV-specific immune responses in antiretroviral naive HIV infected subjects.
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: IT (Prematurely Ended)
Trial results: (No results available)

EudraCT Number: 2004-005055-33

Sponsor Protocol Number: ML17443

Start Date*: 2005-09-01

Sponsor Name:Barts and the London NHS Trust

Full Title: Evaluating the safety and efficacy of mycophenolate mofetil, daclizumab and a single, initial week of corticosteroids in combination with tacrolimus or sirolimus with continued steroid as mainstay ...

Medical condition: Renal Transplantation

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	7.1		10038533		PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (Prematurely Ended)

Trial results: View results

EudraCT Number: 2009-012602-39

Sponsor Protocol Number: 05-NEOV-002

Start Date*: 2010-05-17

Sponsor Name:Fresenius Kabi Deutschland GmbH

Full Title: A randomised, double-blind study evaluating the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact(R) in premature very low bir...

Medical condition: The product is aimed to be used where parenteral nutrition is required. The intended indication is: Supply of essential and non-essential amino acids as part of parenteral nutrition for premature ...

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	12.1		10051284	Parenteral nutrition	LLT

Population Age: Preterm newborn infants, Under 18

Gender: Male, Female

Trial protocol: DE (Prematurely Ended) NL (Prematurely Ended)

Trial results: View results

EudraCT Number: 2009-012608-20

Sponsor Protocol Number: NeoFLOT-2-Studie

Start Date*: 2010-01-29

Sponsor Name:An-Institut für Qualitätssicherung in der operativen Medizin gGmbH

Full Title: Phase II-Studie zur Erfassung der Wirksamkeit einer neoadjuvanten Chemotherapie mit 5-FU/ Leucovorin/ Oxaliplatin/ Docetaxel beim lokal fortgeschrittenen Adenokarzinom des Magens oder des gastroös...

Medical condition: lokal fortgeschrittenes Adenokarzinom des Magens oder des gastroösophagalen Übergangs

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10042090	Stomach carcinoma	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Ongoing)

Trial results: (No results available)

EudraCT Number: 2009-012614-48

Sponsor Protocol Number: H3B110651

Start Date*: 2009-10-26

Sponsor Name:GlaxoSmithKline Research & Development Ltd

Full Title: A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of the H3 receptor antagonist, GSK239512 in subjects with mild to moderate Alzheimer’s disease.

Medical condition: Alzheimer's Disease

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10001896	Alzheimer's disease	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (Completed) DE (Completed) CZ (Completed) BG (Completed) SK (Completed)

Trial results: View results

EudraCT Number: 2007-006177-88

Sponsor Protocol Number: FARM65KNKY

Start Date*: 2008-01-24

Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA

Full Title: A randomized controlled trial of alteplase (rt-PA) vs standard treatment in acute ischemic hemispheric stroke in patients aged more than 80 years where thrombolysis is initiated within 3 hours afte...

Medical condition: acute ischemic stroke

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10043647	Thrombotic stroke	LLT

Population Age: Elderly

Gender: Male, Female

Trial protocol: IT (Ongoing)

Trial results: (No results available)

EudraCT Number: 2009-016716-20

Sponsor Protocol Number: 08/152/WRI

Start Date*: 2010-03-03

Sponsor Name:Brighton and Sussex University Hospitals NHS Trust

Full Title: Better targeting of antidepressants in older people: the influence of age and genetic background on serotonin signalling

Medical condition: Depression

Disease:	Version	SOC Term	Classification Code	Term	Level
	12.0		10021036	Hyponatraemia	LLT
	12.0		10017955	Gastrointestinal haemorrhage	LLT
	12.0		10040108	Serotonin syndrome	LLT

Population Age: Elderly

Gender: Male, Female

Trial protocol: GB (Prematurely Ended)

Trial results: (No results available)

EudraCT Number: 2009-016720-31

Sponsor Protocol Number: 250901

Start Date*: 2010-06-09

Sponsor Name:Baxter Innovations GmbH [...]

Full Title: BAX 326 (recombinant Factor IX): A Phase 1/3 Prospective, Controlled, Multicenter Study Evaluating Pharmacokinetics, Efficacy, Safety, Immunogenicity in Previously Treated Patients with Severe (FIX...

Medical condition: Previously treated patients with severe (FIX level < 1%) or moderately severe (FIX level ≤ 2%) hemophilia B.

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	14.0	10010331 - Congenital, familial and genetic disorders	10018939	Haemophilia B (Factor IX)	LLT

Population Age: Adolescents, Under 18, Adults

Gender: Male, Female

Trial protocol: GB (Completed) DE (Completed) CZ (Completed) ES (Completed) BG (Completed) SE (Completed)

Trial results: View results

EudraCT Number: 2009-011926-32	Sponsor Protocol Number: ALF-BID-1108	Start Date*: 2009-10-21
Sponsor Name:Exalenz Bioscience Ltd [...] 1. Exalenz Bioscience Ltd 2.
Full Title: Breath Test for Patients with Acute Liver Disease for early Detection of the Need for Transplant or Recovery
Medical condition: The study will look at the liver metabolic function in patients with acute liver failure.
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: GB (GB - no longer in EU/EEA)
Trial results: (No results available)

EudraCT Number: 2010-022215-19

Sponsor Protocol Number: GHIGF1/2011

Start Date*: 2011-07-21

Sponsor Name:Greater Glasgow & Clyde NHS

Full Title: A Pharmacokinetic Study Of The Combined Use Of Recombinant Human GH And IGF-1 In Children With Inflammatory Bowel (Crohn’s) Disease

Medical condition: Impaired growth in Paediatric Crohn's disease

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	14.1	100000004856	10011398	Crohn's	LLT

Population Age: Children, Adolescents, Under 18

Gender: Male, Female

Trial protocol: GB (Prematurely Ended)

Trial results: (No results available)

EudraCT Number: 2008-000536-40

Sponsor Protocol Number: BAY38-9456/12093

Start Date*: 2008-03-29

Sponsor Name:Bayer HealthCare AG, D-51368 Leverkusen, Germany

Full Title: Pivotal phase III trial to investigate the efficacy and safety of an Orodispersible Tablet vardenafil versus placebo in the treatment of men with Erectile dysfunction (ED) - a fixed-dose, double-bl...

Medical condition: Erectile Dysfunction (ED)

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	9.1		10061461	Erectile dysfunction	LLT

Population Age: Adults, Elderly

Gender: Male

Trial protocol: NL (Completed) BE (Completed) DE (Completed) FR (Completed) ES (Completed)

Trial results: View results

EudraCT Number: 2009-010594-20	Sponsor Protocol Number: P 0901	Start Date*: 2010-04-13
Sponsor Name:LUMC
Full Title: Thoracic epidural anesthesia with ropivacaine: effects of age on neural blockade and cardiovascular parameters
Medical condition: Medical conditions will not be investigated per se, however we will study the effect of standard thoracic epidural anesthesia on specific age groups undergoing lung surgery
Disease:
Population Age: Adults, Elderly		Gender: Male, Female
Trial protocol: NL (Ongoing)
Trial results: (No results available)

EudraCT Number: 2010-024196-83

Sponsor Protocol Number: CF101-202PS

Start Date*: 2011-03-29

Sponsor Name:Can-Fite BioPharma, Ltd.

Full Title: A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study of the Efficacy and Safety of Daily CF101 Administered Orally in Patients with Moderate-to-Severe Plaque Psoriasis

Medical condition: Moderate-to-Severe Plaque Psoriasis

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	17.1	10040785 - Skin and subcutaneous tissue disorders	10037153	Psoriasis	PT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: BG (Completed)

Trial results: View results

EudraCT Number: 2010-019685-87

Sponsor Protocol Number: RO-2455-404-RD

Start Date*: 2011-04-27

Sponsor Name:Takeda Pharma A/S

Full Title: Effect of roflumilast on exacerbation rate in patients with COPD treated with fixed combinations of LABA and ICS. A 52-week, randomised double-blind trial with roflumilast 500 μg versus placebo

Medical condition: severe chronic obstructive pulmonary disease (COPD)

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	20.0	100000004855	10010952	COPD	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: GB (Completed) BE (Completed) DE (Completed) AT (Completed) DK (Completed) GR (Completed) NL (Completed) HU (Completed) SK (Completed) IT (Completed) ES (Completed)

Trial results: View results

EudraCT Number: 2010-019695-76

Sponsor Protocol Number: MKI113006

Start Date*: 2010-11-11

Sponsor Name:GlaxoSmithKline Research & Development

Full Title: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-centre, Dose Ranging Study to Evaluate the Efficacy and Safety of Losmapimod (GW856553) Tablets Administered Twice Daily compar...

Medical condition: Chronic Obstructive Pulmonary Disease (COPD)

Disease:	Version	SOC Term	Classification Code	Term	Level
Disease:	12.1		10009033	Chronic obstructive pulmonary disease	LLT

Population Age: Adults, Elderly

Gender: Male, Female

Trial protocol: DE (Completed) CZ (Completed) EE (Completed)

Trial results: View results

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The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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