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Clinical trials for Osteoarthritis, Knee AND Pain

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    228 result(s) found for: Osteoarthritis, Knee AND Pain. Displaying page 2 of 12.
    « Previous 1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2021-005046-15 Sponsor Protocol Number: KF7039-03 Start Date*: 2022-06-22
    Sponsor Name:Grünenthal GmbH
    Full Title: A single-arm, open-label, Phase III trial to evaluate the safety and tolerability of intra-articular injections of RTX-GRT7039 in subjects with moderate to severe pain associated with osteoarthrit...
    Medical condition: Moderate to severe pain associated with Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Trial now transitioned) PL (Trial now transitioned) RO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-001076-58 Sponsor Protocol Number: 191622-145 Start Date*: 2015-01-14
    Sponsor Name:Allergan Limited
    Full Title: BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis
    Medical condition: Knee Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004859 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-001185-20 Sponsor Protocol Number: 167700-005CL Start Date*: 2017-12-05
    Sponsor Name:Proximagen Limited
    Full Title: A Randomized, Double Dummy, Parallel Arm, Placebo and Active Controlled, Double Blind, Study of the Safety and Efficacy of PRX167700 as Monotherapy in Adults with Moderate to Severe Knee Pain Due ...
    Medical condition: Moderate to Severe Knee Pain Due to Osteoarthritis in subjects who are Inappropriate for Oral Non steroidal Anti inflammatory Therapy
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031165 Osteoarthritis knee LLT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10024776 Localised osteoarthritis LLT
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031166 Osteoarthritis knees LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-004024-38 Sponsor Protocol Number: 194-P-308 Start Date*: 2013-08-06
    Sponsor Name:Novartis Consumer Health S.A.
    Full Title: A 4-week, randomized, double-blind, multi-center, vehicle-controlled, parallel group study to assess the efficacy and safety of diclofenac diethylamine 2.32% gel for the relief of signs and symptom...
    Medical condition: Knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2021-003124-33 Sponsor Protocol Number: SPA-S-899-01-21 Start Date*: 2023-05-15
    Sponsor Name:SPA-SOCIETÀ PRODOTTI ANTIBIOTICI S.P.A.
    Full Title: Adaptative, multicenter, randomized, double-blind, parallel-group, placebo controlled, clinical trial, on the efficacy and tolerability of different escalating doses of intra-articular clodronate i...
    Medical condition: Patients with painful knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10029877 OA knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-013786-25 Sponsor Protocol Number: IISP 35166 Start Date*: 2010-04-19
    Sponsor Name:Northumbria Healthcare NHS Foundation Trust
    Full Title: Comparison of the effect of Etoricoxib and Diclofenac on early morning activity in RA.
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    12.1 10023476 Knee osteoarthritis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2021-002795-39 Sponsor Protocol Number: CQUC398A12201 Start Date*: 2022-10-14
    Sponsor Name:Novartis Farmacéutica S.A.
    Full Title: A randomized, two-arm, placebo-controlled, participant, investigator and sponsor-blinded, proof-of-concept study investigating the efficacy, safety and tolerability of QUC398 in patients with sympt...
    Medical condition: Knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) FR (Trial now transitioned) NO (Completed) DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-001689-41 Sponsor Protocol Number: RR11/9858 Start Date*: 2013-11-20
    Sponsor Name:University of Leeds
    Full Title: Pain Reduction with Oral Methotrexate in knee Osteoarthritis, a pragmatic phase III trial of Treatment Effectiveness
    Medical condition: Knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031166 Osteoarthritis knees LLT
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-000355-46 Sponsor Protocol Number: Cingal16-02 Start Date*: 2017-07-12
    Sponsor Name:Anika Therapeutics, Inc.
    Full Title: A Randomized, Double-Blind, Active Comparator Controlled, Multi-Center Study of a Single Injection Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal®) to Provide Symp...
    Medical condition: Osteoarthritis of the Knee
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-004515-31 Sponsor Protocol Number: TP-1879 Start Date*: 2020-01-21
    Sponsor Name:Nordic Bioscience Clinical Development A/S
    Full Title: A Phase 2b Trial of SB-061 for the Treatment of Symptomatic Osteoarthritis of the Knee
    Medical condition: Osteoarthritis of the Knee
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-005000-17 Sponsor Protocol Number: JU-BioMiStem-01 Start Date*: 2021-09-20
    Sponsor Name:Jagiellonian University
    Full Title: A Randomized, Double Blind, Two Arms, Controlled Phase I/II Safety and Efficacy Study on MesoCellA-Ortho Tissue Engineered Product Intraarticularly Administrated in Adult Patients with Osteoarthrosis
    Medical condition: articular knee diseases
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-004897-22 Sponsor Protocol Number: CLNA043A12202 Start Date*: 2021-10-18
    Sponsor Name:Novartis Pharma AG
    Full Title: A 5-year, randomized, double-blind, placebo-controlled, multi-center study assessing the efficacy, safety, and tolerability of intra-articular regimens of LNA043 versus placebo in patients with sym...
    Medical condition: osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DK (Trial now transitioned) LT (Completed) CZ (Trial now transitioned) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003395-13 Sponsor Protocol Number: KOA-21-02 Start Date*: 2022-03-03
    Sponsor Name:Bioventus LLC
    Full Title: A Multiple Arm, Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2 Study of Intra-Articular Administration of an Allogeneic Human Placental Tissue Particu...
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-003631-21 Sponsor Protocol Number: CLNA043A12203 Start Date*: 2021-06-28
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, four-arm, canakinumab placebo-controlled, participant, investigator and sponsor-blinded study investigating the safety, tolerability and efficacy of intra-articular canakinumab follow...
    Medical condition: osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) CZ (Prematurely Ended) HU (Prematurely Ended) EE (Completed) LT (Completed) LV (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001028-23 Sponsor Protocol Number: T1010-01 Start Date*: 2017-08-02
    Sponsor Name:Tools4Patient
    Full Title: Validation Study to Investigate the Effect of T4P1010 treatment in Patients with Osteoarthritic Pain of Knee or Hip.
    Medical condition: Osteoarthritic pain of knee or hip.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2008-008237-11 Sponsor Protocol Number: RR08/8797 Start Date*: 2009-05-12
    Sponsor Name:University of Leeds
    Full Title: An open label study to assess the effectiveness of oral methotrexate in reducing pain in knee osteoarthritis
    Medical condition: Painful osteoarthritis of the knee joint.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001970-33 Sponsor Protocol Number: 167700-002CL Start Date*: 2013-07-19
    Sponsor Name:Proximagen Limited
    Full Title: A Double-Blind, Randomised, Exploratory Study to Investigate the Safety, Efficacy and Pharmacokinetics of PRX167700 in Subjects with Knee Osteoarthritis.
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-005048-97 Sponsor Protocol Number: SP905 Start Date*: 2007-05-03
    Sponsor Name:SCHWARZ BIOSCIENCES GmbH
    Full Title: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL TO ASSESS THE EFFICACY AND SAFETY OF 400MG/DAY LACOSAMIDE IN SUBJECTS WITH OSTEOARTHRITIS OF THE KNEE
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    8.1 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) GB (Prematurely Ended) HU (Prematurely Ended) CZ (Completed) SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-000249-14 Sponsor Protocol Number: APPA-P2-1 Start Date*: 2020-08-19
    Sponsor Name:AKL Research and Development Ltd
    Full Title: A placebo-controlled, double-blinded, randomized, trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
    Medical condition: Radiographic and symptomatic knee osteoarthritis in either one or both knees
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-002682-36 Sponsor Protocol Number: DGEL-12058 Start Date*: 2012-09-24
    Sponsor Name:Mylan Pharmaceuticals Inc.
    Full Title: Comparison of the Efficacy of Diclofenac Sodium Topical Gel, 1% (Mylan) to Voltaren® Gel, 1% (Novartis US) and Placebo in Adult Subjects with Knee Osteoarthritis
    Medical condition: Osteoarthritis of joints amenable to topical treatment, such as the knees.
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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