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Clinical trials for Total Knee Replacement

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    The EU Clinical Trials Register currently displays   44349   clinical trials with a EudraCT protocol, of which   7376   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    107 result(s) found for: Total Knee Replacement. Displaying page 2 of 6.
    « Previous 1  2  3  4  5  6  Next»
    EudraCT Number: 2006-001299-19 Sponsor Protocol Number: GJNH-06-01 Start Date*: 2006-05-12
    Sponsor Name:Golden Jubilee National Hospital
    Full Title: Prospective randomised trial comparing intraoperative topical Quixil and intravenous tranexamic acid in reduction of blood loss following primary hip and knee joint replacement surgery
    Medical condition: Elective total knee replacement and total hip replacement.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003154-32 Sponsor Protocol Number: N/A Start Date*: 2017-09-18
    Sponsor Name:University of Leeds
    Full Title: SPAARK: Study of Peri-Articular Anaesthetic for Replacement of the Knee. The clinical and cost effectiveness of peri-articular liposomal bupivacaine compared with bupivacaine hydrochloride alone fo...
    Medical condition: Local anaesthetic for patients undergoing knee replacement surgery for arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-005596-90 Sponsor Protocol Number: NL51548.100.14 Start Date*: 2015-04-22
    Sponsor Name:St. Lucas Andreas Hospital
    Full Title: Comparison of femoral nerve block with posterior capsule infiltration versus anterior and posterior capsule infiltration after total knee replacement.
    Medical condition: patienst requiring total knee replacement for non-inflammatory osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002634-20 Sponsor Protocol Number: NBF_HK_01_2018 Start Date*: 2018-10-23
    Sponsor Name:Anaesthesia Department, Hvidovre Hospital, Capital Region of Denmark
    Full Title: Highdose steroid for total knee arthroplasty - A randomized doubleblindet controlled trial.
    Medical condition: Perioperative management of total knee-arthroplasty because of knee-osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10023469 Knee arthroplasty PT
    20.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-002549-12 Sponsor Protocol Number: A4091064 Start Date*: 2015-09-08
    Sponsor Name:Pfizer Inc, 235 East 42nd Street, New York, NY 10017
    Full Title: A PHASE 3, MULTICENTER, LONG-TERM OBSERVATIONAL STUDY OF SUBJECTS FROM TANEZUMAB STUDIES WHO UNDERGO A TOTAL KNEE, HIP OR SHOULDER REPLACEMENT
    Medical condition: Osteoarthritis of the hip or knee
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10023476 Knee osteoarthritis LLT
    18.1 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) AT (Completed) ES (Completed) BG (Completed) DE (Completed) PT (Completed) FI (Completed) GB (Completed) SE (Completed) LT (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2017-000180-32 Sponsor Protocol Number: 761 Start Date*: 2017-02-10
    Sponsor Name:Sint Maartenskliniek Nijmegen
    Full Title: Pharmacokinetic Profile of Ropivacaine after Periarticular Local Infiltration Analgesia for Primary Total Knee Arthroplasty Without the use of a Tourniquet.
    Medical condition: patients receiving primary total knee replacement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-011492-73 Sponsor Protocol Number: 13.09 Start Date*: 2009-09-28
    Sponsor Name:Swindon and Marlborough NHS Foundation Trust
    Full Title: Analysis of Blood Loss With the Use of Fibrin Sealant in Total Knee Replacement Surgery – A Randomised Controlled Study
    Medical condition: Blood loss in total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-011784-37 Sponsor Protocol Number: FORSS-37511 Start Date*: 2009-09-17
    Sponsor Name:Department of Orthopaedics IKE
    Full Title: Does teriparatide lower the risk for loosening of a knee prosthesis?
    Medical condition: Knee osteoarthritis. In animal studies teriparatide has shown a positive effect on fracture healing. So far, teriparatide (Forsteo ®) is only registrered for treatment of severe osteoporosis. A ce...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001128-19 Sponsor Protocol Number: CV185-010 Start Date*: 2004-11-02
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Phase 2 Randomized, Double Blinded (BMS-562247 and enoxaparin), Active-Controlled (enoxaparin and warfarin), Parallel-Arm, Dose Response Study of the Oral Factor Xa Inhibitor BMS-562247 in Subjec...
    Medical condition: Prevention of asymptomatic and symptomatic deep vein thrombosis (DVT) and non-fatal pulmonary embolism (PE) in subjects undergoing knee replacement surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2007-000262-20 Sponsor Protocol Number: DPOD III Start Date*: 2007-07-25
    Sponsor Name:Stanmore Clinical Research Facility Ltd
    Full Title: A phase III, 7 days randomised, double-blind, placebo-controlled, parallel group study to assess efficacy of DPZ for reducing the symptoms of post-operative delirium after an elective hip or knee r...
    Medical condition: Post-operative delirium.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012218 Delirium LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001317-34 Sponsor Protocol Number: 1160.25 Start Date*: 2004-11-01
    Sponsor Name:Boehringer Ingelheim Finland Ky
    Full Title: A phase III, randomised, parallel-group, double-blind, active controlled study to investigate the efficacy and safety of two different dose regimens of orally administered dabigatran etexilate caps...
    Medical condition: Prevention of venous thromboembolism following primary elective total knee replacement surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) SE (Completed) DE (Completed) AT (Completed) HU (Completed) DK (Completed) CZ (Completed) IT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2006-002161-39 Sponsor Protocol Number: CV185-034 Start Date*: 2006-12-05
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Phase 3 Randomized, Double-Blind, Active-Controlled (Enoxaparin), Parallel Group, Multi-Center Study to Evaluate the Safety and Efficacy of Oral Apixaban in Subjects Undergoing Elective Total Kne...
    Medical condition: Subjects undergoing elective total knee replacement surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) SE (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2007-007813-35 Sponsor Protocol Number: TBA Start Date*: 2008-06-16
    Sponsor Name:University Hospital of North Tees and Hartlepool
    Full Title: Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Cemented Total Knee Replacement (TRANX-K).
    Medical condition: In this study Tranexamic acid efficacy in reducing blood loss will be investigated in total knee replacement.Tranexamic acid will be applied topically to the exposed tissue around the knee joint pr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023227 Joint replacement LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2015-002661-36 Sponsor Protocol Number: 15039DB-SW Start Date*: 2016-03-10
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Single centre randomised controlled trial to assess the effect of the addition of twenty-four hours of oral tranexamic acid post-operatively to a single intra-operative intravenous dose of tranexam...
    Medical condition: Osteoarthritic patients who require hip or knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-003010-93 Sponsor Protocol Number: 620 Start Date*: 2014-10-15
    Sponsor Name:Sint Maartenskliniek
    Full Title: Pharmacokinetic Profile of Ropivacaïne after Periarticular Local Infiltration Analgesia for Primary Total Knee Arthroplasty
    Medical condition: patients receiving primary total knee replacement
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2005-001229-27 Sponsor Protocol Number: Fybex02/Parexel 71786 Start Date*: 2005-11-23
    Sponsor Name:Bio Products Laboratory
    Full Title: A randomized, sigle-blind, parallel group, multicentre comparative study to assess the efficacy and safety of an application of Fybex (fibrin sealant) to the operative field, for the reduction of p...
    Medical condition: Total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-001644-35 Sponsor Protocol Number: CR_TFB_2017 Start Date*: 2017-06-01
    Sponsor Name:Aarhus University Hospital
    Full Title: The effect of popliteal plexus block on pain after total knee replacement
    Medical condition: In this study we investigate pain after total knee replacement
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2011-000693-57 Sponsor Protocol Number: Ledin03 Start Date*: 2011-11-29
    Sponsor Name:Håkan Ledin (investigator initiated trial)
    Full Title: A Randomized, Placebo-controlled, Double-blind, Two-center Study with Denosumab in Subjects Undergoing Elective Total Knee Replacement Surgery
    Medical condition: Patients with idiopathic osteoarthritis of the knee, scheduled for a cemented total knee prosthesis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-001008-13 Sponsor Protocol Number: 497 Start Date*: 2013-09-18
    Sponsor Name:Sint Maartenskliniek
    Full Title: Fast-track rehabilitation protocol for Total Knee Arthroplasty: A Randomized Controlled Trial comparing Local Infiltration Analgesia with Femoral Nerve Block
    Medical condition: patients requiring total knee arthroplasty for non-inflammatory osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-005010-36 Sponsor Protocol Number: CR-TFB-2013/502 Start Date*: 2014-01-08
    Sponsor Name:Thomas Fichtner Bendtsen
    Full Title: The effect of protracted saphenous nerve and obturator nerve blockade versus saphenous nerve blockade versus local infiltration analgesia in opioid consumption, pain, blockade duration of action an...
    Medical condition: The medical condition to be examined in this study is the first postoperative period after total knee replacement with a view to pain management.
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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