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Clinical trials for Knee Arthroplasty

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    101 result(s) found for: Knee Arthroplasty. Displaying page 3 of 6.
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    EudraCT Number: 2016-002251-13 Sponsor Protocol Number: 24052016 Start Date*: 2016-11-09
    Sponsor Name:Oulu university hospital
    Full Title: The effect of intravenous single-dose dexamethasone on pain after total knee replacement surgery.
    Medical condition: Patients with arthrosis of knee joint needing operative treatment i.e. arthroplasty of knee.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-019669-27 Sponsor Protocol Number: 121 Start Date*: 2010-04-30
    Sponsor Name:University of Tartu
    Full Title: Hypobaric vs hyperbaric bupivacaine for spinal anaesthesia in total knee arthroplasty
    Medical condition: Orthopedic surgery patients with elective total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: View results
    EudraCT Number: 2016-002035-15 Sponsor Protocol Number: 0 Start Date*: 2016-05-20
    Sponsor Name:Helsinki University Central Hospital
    Full Title: Outcome after total knee arthroplasty under general or spinal anesthesia, a randomized study
    Medical condition: Patients undego total knee arthroplasty operation in general or spinal anaesthesia because of osteoarthritis, rheumatoid arthritis or other degenerative condition of the knee
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004859 10031174 Osteoarthrosis LLT
    19.0 100000004859 10031158 Osteo arthritis knees LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002769-72 Sponsor Protocol Number: SM1-DHAG-2016 Start Date*: 2016-08-29
    Sponsor Name:Næstved Hospital
    Full Title: DEXRAR: DEXamethasone in Revision ARthroplasty: A randomised, blinded, 2-group clinical trial
    Medical condition: Pain after revision surgery after total knee replacement
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10057129 Revision of total knee arthroplasty LLT
    19.0 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-004638-33 Sponsor Protocol Number: 2006-122 Start Date*: 2006-11-21
    Sponsor Name:Department of Orthopedic Surgery, Aarhus University
    Full Title: Postoperative pain relief for primary total knee arthroplasty: A randomised clinical trial of local infiltration anaesthesia followed by intraaticulary infusion compared to epidural infusion
    Medical condition: Patients with Osteoarthrosis undergoing elective total knee arthroplasty (TKA)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-001432-62 Sponsor Protocol Number: 2012-006-M Start Date*: 2012-08-28
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Local infiltration anesthesia in Total Knee Arthroplasty
    Medical condition: Local infiltration analgesia (LIA) a multimodal pain management strategy in total knee arthroplasty.This study will investigate the effect of LIA on postoperative pain, opiod consumption, length of...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-005010-36 Sponsor Protocol Number: CR-TFB-2013/502 Start Date*: 2014-01-08
    Sponsor Name:Thomas Fichtner Bendtsen
    Full Title: The effect of protracted saphenous nerve and obturator nerve blockade versus saphenous nerve blockade versus local infiltration analgesia in opioid consumption, pain, blockade duration of action an...
    Medical condition: The medical condition to be examined in this study is the first postoperative period after total knee replacement with a view to pain management.
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-003343-35 Sponsor Protocol Number: CR-TFB-2014/502 Start Date*: 2014-10-01
    Sponsor Name:Thomas Fichtner Bendtsen
    Full Title: The effect of saphenous nerve and obturator nerve block combined with systemic high dose glucocorticoid versus local infiltration analgesia combined with a systemic high dose glucocorticoid on opi...
    Medical condition: The medical condition to be examined in this study is the first postoperative period after total knee replacement with a view to pain management.
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2021-003395-13 Sponsor Protocol Number: KOA-21-02 Start Date*: 2022-03-03
    Sponsor Name:Bioventus LLC
    Full Title: A Multiple Arm, Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2 Study of Intra-Articular Administration of an Allogeneic Human Placental Tissue Particu...
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-000405-27 Sponsor Protocol Number: 05JM128 Start Date*: 2006-06-01
    Sponsor Name:Greenpark Health Care Trust
    Full Title: Postoperative pain and mobility outcomes after primary hip and knee arthroplasty. A comparison of intravenous morphine with local wound infiltration.
    Medical condition: Osteoarthritis of the hip and knee joints
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-002480-17 Sponsor Protocol Number: FPS-TRA-2017-02 Start Date*: 2017-11-13
    Sponsor Name:Fundación Pública Andaluza Progreso y Salud
    Full Title: Randomized, placebo-controlled, double-blind trial to evaluate the efficacy and safety of topical application of tranexamic acid for saving blood losses in patients subjected to prosthetic knee su...
    Medical condition: Knee arthrosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-001200-55 Sponsor Protocol Number: 564038 Start Date*: 2015-09-23
    Sponsor Name:Region Östergötland
    Full Title: A single postoperative bisphosphonate infusion to improve patient reported function after hip or knee replacement.
    Medical condition: Prosthetic loosening of hip and knee arthroplasty
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005443-23 Sponsor Protocol Number: FEMTIB2020 Start Date*: 2021-06-21
    Sponsor Name:Hospital Sant Joan de Reus
    Full Title: Comparative study between two ultrasound-guided peripheral blocks for postoperative analgesia of primary total knee arthroplasty
    Medical condition: Patients undergoing knee replacement
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000295-94 Sponsor Protocol Number: TPO-150 Start Date*: 2015-10-13
    Sponsor Name:St Olavs University Hospital
    Full Title: Use of long acting opioids for pre- and postoperative analgesia in primary total knee arthroplasty. A double-blinded randomized control trial. Tapentadol vs Oxycodon vs Placebo
    Medical condition: Pain therapy for total knee arthroplasty (total knee replacement)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004863 10036286 Post-operative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2007-007813-35 Sponsor Protocol Number: TBA Start Date*: 2008-06-16
    Sponsor Name:University Hospital of North Tees and Hartlepool
    Full Title: Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Cemented Total Knee Replacement (TRANX-K).
    Medical condition: In this study Tranexamic acid efficacy in reducing blood loss will be investigated in total knee replacement.Tranexamic acid will be applied topically to the exposed tissue around the knee joint pr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023227 Joint replacement LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-004931-25 Sponsor Protocol Number: INDEX Start Date*: 2021-09-10
    Sponsor Name:Turku University Hospital
    Full Title: Intranasal dexmedetomidine pharmacokinetics on patients under general anesthesia
    Medical condition: Knee osteoarthritis Hip osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10020108 Hips osteoarthritis LLT
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005179-25 Sponsor Protocol Number: 402-C-326 Start Date*: 2016-06-10
    Sponsor Name:Pacira Pharmaceuticals, Inc.
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block with EXPAREL for Postsurgical Analgesia in Subjects Un...
    Medical condition: Total Knee Arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2018-003537-15 Sponsor Protocol Number: TXA2018 Start Date*: 2019-02-18
    Sponsor Name:Medical University Vienna
    Full Title: Different dosing of Tranexamic Acid in patients undergoing elective total hip or knee arthroplasty. A randomized, controlled, double-blinded clinical trial.
    Medical condition: Blood loss in patients undergoing elective total hip or knee arthroplasty.
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10053220 Hip injury LLT
    20.1 100000004863 10049032 Knee injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002661-36 Sponsor Protocol Number: 15039DB-SW Start Date*: 2016-03-10
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Single centre randomised controlled trial to assess the effect of the addition of twenty-four hours of oral tranexamic acid post-operatively to a single intra-operative intravenous dose of tranexam...
    Medical condition: Osteoarthritic patients who require hip or knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-000982-38 Sponsor Protocol Number: 06/JM/119 Start Date*: 2007-06-14
    Sponsor Name:Greenpark Health Care Trust
    Full Title: Pain and mobility outcomes following patient controlled lumbar plexus block for primary joint arthroplasty
    Medical condition: Pain control after primary joint arthroplasty
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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