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Clinical trials for Chronic Pain

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    1,162 result(s) found for: Chronic Pain. Displaying page 6 of 59.
    EudraCT Number: 2017-001296-23 Sponsor Protocol Number: 61409 Start Date*: 2019-06-03
    Sponsor Name:Radboudumc
    Full Title: The efficacy of botulinum toxin A injection in pelvic floor muscles in chronic pelvic pain patients: a double-blinded randomised controlled trial
    Medical condition: Patients with >6 months or recurrent episodes of abdomino-perineo-pelvic pain, hypersensitivity or discomfort often associated with elimination changes, and sexual dysfunction in the absence of org...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005426-19 Sponsor Protocol Number: 51237 Start Date*: 2016-02-09
    Sponsor Name:Rigshospitalet, Copenhagen University Hospitals
    Full Title: "Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia in Patients following Recovery from Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, ...
    Medical condition: Healthy volunteers (n = 94) are included. The main study includes 14 subjects who have had an uncomplicated, impacted mandibular, third molar extraction 4-5 weeks prior to participation in the stud...
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004867 10049475 Chronic pain LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2015-004269-96 Sponsor Protocol Number: IG8801CLBP201 Start Date*: 2016-02-24
    Sponsor Name:Gador S.A.
    Full Title: A 24 weeks multicentre, randomized, double-blind, placebo-controlled, parallel group, study to evaluate the efficacy, safety and tolerability of intravenous IG-8801 20 mg and 40 mg in subjects with...
    Medical condition: non-specific Chronic Low Back Pain persisting for at least 3 months
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10008837 Chronic back pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-000483-25 Sponsor Protocol Number: 01/07 Start Date*: 2007-01-15
    Sponsor Name:OSPEDALE ISRAELITICO DI ROMA
    Full Title: Buprenorfina TDS in old patients with chronic pain not give moderated cancer of intensita serious. Study in open, of Phase IV, not controlled, multicentric, spontaneous
    Medical condition: old patients ultra 65 with chronic pain do not give cancer
    Disease: Version SOC Term Classification Code Term Level
    6.1 10028411 PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-001861-33 Sponsor Protocol Number: P19.050 Start Date*: 2019-07-17
    Sponsor Name:Leiden University Medical Center
    Full Title: Cannabis-opioid interaction in the treatment of fibromyalgia pain – an open label proof-of-concept study
    Medical condition: Chronic fibromyalgia pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023775-25 Sponsor Protocol Number: 3652-CL-0019 Start Date*: 2011-08-02
    Sponsor Name:Astellas Pharma Europe B.V.
    Full Title: A Phase II, Randomized, Double-blind, Placebo-controlled, Parallel group, Adaptive, combined Proof of Concept and Dose-Finding study to investigate Efficacy, Safety, Pharmacodynamics and Pharmacoki...
    Medical condition: Chronic abacterial Prostatitis/Chronic Pelvic Pain Syndrome
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004872 10064189 Chronic pelvic pain syndrome LLT
    14.1 100000004872 10009109 Chronic prostatitis LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DE (Completed) CZ (Completed) LT (Completed) LV (Completed) PL (Completed) ES (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-002935-28 Sponsor Protocol Number: FENT-05104 Start Date*: 2005-07-21
    Sponsor Name:Bertek Pharmaceuticals International Limited
    Full Title: Single-Dose, Two Treatment, Four-Way Crossover Replicate Design to Assess the Bioequivalence of two Fentanyl Transdermal Delivery Systems MYLAN (25ug/h) and Durogesic Dtrans (25ug/h) in Healthy Vol...
    Medical condition: Potent opioid analgesic indicated for the treatment of chronic pain.
    Disease: Version SOC Term Classification Code Term Level
    7 10049475 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-004861-25 Sponsor Protocol Number: A4091019 Start Date*: 2009-03-05
    Sponsor Name:Pfizer Ltd., Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
    Full Title: A PHASE 2, 16 WEEK, MULTICENTER, RANDOMIZED, DOUBLE-BLIND PLACEBO-CONTROLLED, PARALLEL GROUP PROOF-OF-CONCEPT STUDY EVALUATING THE EFFICACY AND SAFETY OF TANEZUMAB FOR THE TREATMENT OF PAIN ASSOCIA...
    Medical condition: Chronic Abacterial Prostatitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10009109 Chronic prostatitis LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: SE (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2012-001349-41 Sponsor Protocol Number: MD2012/1 Start Date*: 2012-05-15
    Sponsor Name:AZ Groeninge
    Full Title: Influence of dexamethasone on postoperative analgesia after combined spinal epidural for cesarean delivery.
    Medical condition: Postoperative pain
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001316-35 Sponsor Protocol Number: KF6005/07 Start Date*: 2012-12-20
    Sponsor Name:Grünenthal GmbH
    Full Title: Efficacy, safety, and tolerability of oral Cebranopadol versus morphine sulphate PR in subjects with chronic moderate to severe pain related to cancer.
    Medical condition: The trial population, comprising patients with cancer pain requiring WHO Step III analgesics, will represent the typical population suffering from cancer-related pain. Patient having various types ...
    Disease: Version SOC Term Classification Code Term Level
    17.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10058019 Cancer pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed) DE (Prematurely Ended) HU (Completed) SE (Completed) ES (Completed) SK (Completed) PL (Completed) NL (Completed) AT (Completed) DK (Completed) BG (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2010-022025-15 Sponsor Protocol Number: 10-2-055 Start Date*: 2011-02-21
    Sponsor Name:MUMC
    Full Title: Intradiscal Methylene Blue Injection Treatment for Chronic Discogenic Low back pain A prospective Clinical Series followed by a Randomised Placebo-Controlled Clinical Trial
    Medical condition: The Randomized Clinical Trial (RCT) aims to prove the hypothesis that Intradiscal Methylene blue Injection is capable of better pain reduction than the best available treatment in patients sufferin...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023331-42 Sponsor Protocol Number: IMIOXC Start Date*: 2010-12-15
    Sponsor Name:Department of Neurology, Odense University Hospital
    Full Title: Oxcarbazepine for the treatment of chronic peripheral neuropathic pain: predictors of response - a randomised, double-blind, placebo-controlled clinical trial
    Medical condition: Chronic peripheral neuropathic pain caused by polyneuropathy, postherpetic neuralgia and traumatic/surgical nerve injury.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10054095 Neuropathic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-003077-26 Sponsor Protocol Number: IMIVER Start Date*: 2012-08-13
    Sponsor Name:Department of Neurology, Odense University Hospital
    Full Title: Topical lidocaine for the treatment of focal peripheral neuropathic pain: response in relation to pain phenotype
    Medical condition: Chronic peripheral neuropathic pain caused by postherpetic neuralgia and traumatic/surgical nerve injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10054095 Neuropathic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003782-28 Sponsor Protocol Number: R475-PN-1524 Start Date*: 2016-02-15
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: A RANDOMIZED, DOUBLE-BLIND, MULTI-DOSE, PLACEBO-CONTROLLED PHASE 2/3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FASINUMAB IN PATIENTS WITH MODERATE TO SEVERE CHRONIC LOW BACK PAIN
    Medical condition: Chronic Low Back Pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10003988 Back pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) CZ (Completed) PL (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2021-000103-20 Sponsor Protocol Number: 202000638 Start Date*: 2021-07-15
    Sponsor Name:University Medical Center Groningen
    Full Title: An explorative randomized, placebo-controlled and double-blind intervention crossover study: Transvamix (100mg/mL THC / 50mg/mL CBD) to treat chronic pain in Epidermolysis Bullosa
    Medical condition: Genetic Epidermolysis Bullosa
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001629-38 Sponsor Protocol Number: KLG0121 Start Date*: 2022-02-21
    Sponsor Name:Dompè Farmaceutici S.p.A.
    Full Title: A phase 2, multicenter, randomized, double blind, active controlled, parallel group study assessing the analgesic effect and safety of two doses of DFL24412 in patients with chronic low back pain c...
    Medical condition: Chronic Low Back Pain
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10052430 Chronic lumbago LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2006-003151-21 Sponsor Protocol Number: INT 35/06 Start Date*: 2006-08-31
    Sponsor Name:ISTITUTO NAZIONALE PER LA CURA TUMORI
    Full Title: Study to compare the tolerability of slow release oxycodone versus slow release morphine in the treatment of severe cancer pain. The study is geared towards a clinical practice improvement.
    Medical condition: Advanced cancer patient with severe cancer pain
    Disease: Version SOC Term Classification Code Term Level
    6.1 10033371 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-003304-12 Sponsor Protocol Number: A0081279 Start Date*: 2013-02-12
    Sponsor Name:Pfizer Inc, 235 East 42nd Street, New York, NY 10017
    Full Title: A Randomized Double Blind Placebo Controlled Parallel Group Study of the Efficacy and Safety of Pregabalin (BID) in Subjects with Post-Traumatic Peripheral Neuropathic Pain
    Medical condition: Chronic post-traumatic peripheral neuropathic pain
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004852 10054095 Neuropathic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) BG (Completed) HU (Completed) BE (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2007-004267-22 Sponsor Protocol Number: 2348/2007 Start Date*: 2007-11-15
    Sponsor Name:AZIENDA OSPEDALIERA PISANA
    Full Title: Pharmacogenetic evaluation of oxicodone in patients.
    Medical condition: Cancer chronic pain.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-006042-41 Sponsor Protocol Number: NC3-project Start Date*: 2006-05-15
    Sponsor Name:Karolinska Institutet
    Full Title: Local treatment of craniomandibular myofascial pain with the 5-HT3 receptor antagonist granisetron. A randomized and double-blind study.
    Medical condition: Craniomandibular myalgia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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