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Clinical trials for Heart surgery

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    628 result(s) found for: Heart surgery. Displaying page 6 of 32.
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    EudraCT Number: 2014-004610-29 Sponsor Protocol Number: 2014.001 Start Date*: 2015-02-18
    Sponsor Name:Skanes University Hospital
    Full Title: Ciclosporin to Protect Renal function In Cardiac Surgery. CiPRICS. A Phase II Double Blind Randomized Placebo Controlled Study.
    Medical condition: Renal dysfunction after CABG surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2006-003164-62 Sponsor Protocol Number: 1976 Start Date*: 2007-01-22
    Sponsor Name:University Hospital Birmingham
    Full Title: Metabolic Support with Perhexilene to Protect Myocardium undergoing Coronary Artery Surgery
    Medical condition: Patients undergoing coronary artery bypass surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-004901-41 Sponsor Protocol Number: PREFERCABG01 Start Date*: 2018-04-19
    Sponsor Name:Hospital District of Southwestern Finland
    Full Title: A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elect...
    Medical condition: Patients undergoing elective coronary artery bypass grafting surgery, the study investigates the prevention of postoperative infections and blood transfusions.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001464-19 Sponsor Protocol Number: GE-122-020 Start Date*: 2016-02-11
    Sponsor Name:GE Healthcare Ltd. and its affiliates
    Full Title: AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30%≤LVEF≤35% ADMIRE-ICD
    Medical condition: Heart failure
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004849 10064081 Heart failure NYHA class III LLT
    18.1 100000004849 10064080 Heart failure NYHA class II LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) ES (Prematurely Ended) NL (Prematurely Ended) CZ (Prematurely Ended) DE (Prematurely Ended) DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-019713-21 Sponsor Protocol Number: CS/2007/2678 Start Date*: 2010-06-17
    Sponsor Name:University Hospitals Bristol NHS Foundation Trust
    Full Title: A RANDOMISED CONTROLLED TRIAL TO COMPARE NORMOXIC VERSUS STANDARD CARDIOPULMONARY BYPASS IN CYANOTIC CHILDREN UNDERGOING CARDIAC SURGERY
    Medical condition: The study investigates reoxygenation injury in cyanotic paediatric patients undergoing on-pump cardiac surgery. The types of heart condition being investigated result in chronic low blood oxygen sa...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10010395 Congenital cardiac malpositions and transpositions HLT
    12.1 10010397 Congenital cardiac structural defects NEC HLT
    12.1 10010396 Congenital cardiac septal defect NOS LLT
    12.1 10062326 Congenital cardiac septal defect LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000980-42 Sponsor Protocol Number: V1.1/13.05.2014 Start Date*: 2014-09-26
    Sponsor Name:Medical University Vienna
    Full Title: Feasibility and safety of intensified preoperative glucose control in patients with type 2 diabetes undergoing cardiovascular surgery – a pilot study
    Medical condition: The objective of this study is to investigate whether a targeted preoperative glucose control before planned cardiac surgery by i.v. insulin infusion (intensified glycemic control, ICG) versus st...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-001384-27 Sponsor Protocol Number: 2022-031 Start Date*: 2023-02-28
    Sponsor Name:Franciscus Gasthuis & Vlietland
    Full Title: Peroperative Administration of Tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce hemorrhage rates (PATRY study): a randomized controlled trial
    Medical condition: Morbid obesity
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10059610 Obesity surgery LLT
    21.0 100000004861 10027966 Morbid obesity LLT
    21.1 100000004865 10068900 Bariatric surgery LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-000442-21 Sponsor Protocol Number: RC17_0029 Start Date*: 2017-09-12
    Sponsor Name:CHU de Nantes
    Full Title: Effects of perioperative administration of dexamethasone on postoperative complications and mortality after non-cardiac major surgery : a randomized, multicentre, double blind, study
    Medical condition: non-cardiac major surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10042609 Surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-015826-13 Sponsor Protocol Number: Q-10 Start Date*: 2010-10-07
    Sponsor Name:PROF. TIZIANO GHERLI
    Full Title: THE USE OF COENZYME Q 10 BEFORE HEART SURGERY IN ELDERLY PATIENTS.
    Medical condition: Patients (male or female) aged > 70 years, clinically stable, with a diagnosis of severe aortic stenosis with indication to surgery based on echocardiography and left ventricle angiography.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10049194 Stable angina pectoris LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-002834-36 Sponsor Protocol Number: Retro-001 Start Date*: 2012-09-13
    Sponsor Name:UMCG
    Full Title: Evaluation of the effects of the addition of atropine during propofol/remifentanil induction of anesthesia on hemodynamics, microvascular blood flow and tissue oxygenenation in patients undergoing ...
    Medical condition: ophthalmic surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-004501-27 Sponsor Protocol Number: 2183/2019 Start Date*: 2021-01-28
    Sponsor Name:Medical University of Vienna
    Full Title: Perioperative analgesia in children undergoing ophthalmic surgery
    Medical condition: perioperative analgesia
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003088-76 Sponsor Protocol Number: 11-170 Start Date*: 2014-07-14
    Sponsor Name:Clinical Evaluation Research Unit (CERU)
    Full Title: SodiUm SeleniTe Adminstration IN Cardiac Surgery surgery (SUSTAIN CSX®-trial) - A randomized controlled trial of high dose sodium-selenite administration in high risk cardiac surgical patients
    Medical condition: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and is well recognised for its prominent role in immune defence. Selenoproteins have the potential t...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006514-37 Sponsor Protocol Number: DOAC-CO Start Date*: 2023-02-08
    Sponsor Name:Ente Ecclesiastico Ospedale Generale Regionale “F. Miulli”
    Full Title: Haemorrhagic risk of direct oral anticoagulants (DOACs) in patients undergoing oral surgery
    Medical condition: Patients on direct acting oral anticoagulants (DOACs) who are to undergo oral surgery.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10007521 Cardiac arrhythmias HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2009-013226-17 Sponsor Protocol Number: AustrNHMRVID436677 Start Date*: 2009-09-29
    Sponsor Name:Plymouth Hospitals NHS Trust
    Full Title: The ENIGMA-II Trial. Nitrous oxide anaesthesia and cardiac morbidity after major surgery: a randomised controlled trial
    Medical condition: The study investigates standard anaesthesia for surgery. There is no single specific 'disease' rather there is a population of patients requiring anaesthesia to permit surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003413-10 Sponsor Protocol Number: ACDHUVV-16 Start Date*: 2016-12-20
    Sponsor Name:FIMABIS
    Full Title: MicroRNAs expression analysis in patients undergoing cardiac surgery treated with halogenated anesthetics. Identification of microRNAs related to the cardioprotective effect
    Medical condition: Cardiac surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002385-39 Sponsor Protocol Number: HSPOD Start Date*: 2018-12-06
    Sponsor Name:County Council of Västerbotten
    Full Title: Infusion of hypertonic solutions: A risk factor for delirium after cardiac surgery? A randomised double blinded controlled trial.
    Medical condition: The present investigation aims to investigate the risk of developing delirium after cardiac surgery, when using a hyperosmolar priming solution for cardiopulmonary bypass
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2018-001430-18 Sponsor Protocol Number: 5101127 Start Date*: 2019-08-12
    Sponsor Name:Kuopio University Hospital
    Full Title: Does postoperative intravenous corticosteroid and intravenous beta blocker management prevent atrial fibrillation after cardiac surgery?
    Medical condition: new onset atrial fibrillation and paroxysmal atrial fibrillation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000077-57 Sponsor Protocol Number: 2021-THORANE-Pharma-001 Start Date*: 2022-06-25
    Sponsor Name:Rigshospitalet
    Full Title: Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomiz...
    Medical condition: We investigate the efficacy of methadonehydrochloride for reducing optoperative opioid requirements, pain scores and improving quality of recovery in patients undergoing heart surgery (i.e. corona...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10008937 Chronic ischemic heart disease, unspecified LLT
    20.0 10007541 - Cardiac disorders 10002911 Aortic valvular disorders HLT
    20.0 10007541 - Cardiac disorders 10061532 Mitral valve disease PT
    20.0 10042613 - Surgical and medical procedures 10062202 Mitral valve repair PT
    20.0 10042613 - Surgical and medical procedures 10027732 Mitral valve replacement PT
    20.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    20.0 10042613 - Surgical and medical procedures 10061652 Aortic valve repair PT
    21.1 10042613 - Surgical and medical procedures 10011077 Coronary artery bypass PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2004-003595-11 Sponsor Protocol Number: 2004-06-DP-119-RKF-25 Start Date*: 2005-03-18
    Sponsor Name:Canadian Cardiovascular Collaboration, Population Health Research Institute, McMaster University
    Full Title: PeriOperative ISchemic Evaluation study
    Medical condition: Perioperative cardiac events frequently complicate non-cardiac surgery resulting in significant morbidity, mortality and cost. There is no clear evidence from RCTs on how to lower perioperative ca...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-002661-35 Sponsor Protocol Number: FERRICCABG01 Start Date*: 2020-04-23
    Sponsor Name:King's College London [...]
    1. King's College London
    2. King's College Hospital NHS Foundation Trust
    Full Title: Effect of Iron Isomaltoside on Perioperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Graft ± Valve Surgery: The Ferric Iron in Coronary Artery Bypass Grafting (FERRIC-CABG) ...
    Medical condition: Coronary or heart valve disease needing cardiac surgery
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10068617 Coronary heart disease LLT
    20.0 100000004849 10019316 Heart valve disorders LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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