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Clinical trials for Surgery

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    5,833 result(s) found for: Surgery. Displaying page 6 of 292.
    EudraCT Number: 2017-004901-41 Sponsor Protocol Number: PREFERCABG01 Start Date*: 2018-04-19
    Sponsor Name:Hospital District of Southwestern Finland
    Full Title: A Phase IV Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Elect...
    Medical condition: Patients undergoing elective coronary artery bypass grafting surgery, the study investigates the prevention of postoperative infections and blood transfusions.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-013707-63 Sponsor Protocol Number: 1 Start Date*: 2010-03-05
    Sponsor Name:C.U.B ERASME HOSPITAL
    Full Title: POSTOPERATIVE ANALGESIA USING PREPERITONEAL CONTINUOUS INFUSIONS OF ROPIVACAINE IN PATIENTS UNDERGOING LIVER SURGERY -CONSEQUENCES ON ROPIVACAINE METABOLISM
    Medical condition: PATIENTS WITH HEPATIC TUMORS BUT WITH A GOOD HEPATIC FUNCTION BEFORE SURGERY
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-003506-26 Sponsor Protocol Number: CI-331-19 Start Date*: 2020-03-05
    Sponsor Name:Hospital Universitari Son Espases
    Full Title: Determination of Parathyroid Function by Fluorescence With Indocyanine Green (ICG) After Total Thyroidectomy
    Medical condition: Patients undergoing total thyroidectomy with visualization of the parathyroid glands under infrared light after intraoperative intravenous injection of 5 mg of indocyanine green to predict the poss...
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004861 10020949 Hypocalcemia LLT
    20.0 100000004865 10043777 Thyroidectomy total LLT
    21.0 10022117 - Injury, poisoning and procedural complications 10080819 Post procedural hypoparathyroidism PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001806-32 Sponsor Protocol Number: ARG-01 Start Date*: 2021-12-14
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: Influence of Argipressin on blood loss and inflammatory response during hepatic resection; a double blinded, randomized, placebo-controlled trial
    Medical condition: Hepatic resection due to primary malignant disease, metastasis or benign tumour
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10019701 Hepatic neoplasm malignant resectable LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-003277-34 Sponsor Protocol Number: T2380-PIV-017 Start Date*: 2018-01-15
    Sponsor Name:Laboratoires Théa
    Full Title: Phase IV, open-label, randomized clinical trial to evaluate the effects of Fydrane® and standard topical mydriatics and anaesthetics protocol on ocular surface after cataract surgery.
    Medical condition: Cataracts
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10007739 Cataract PT
    20.0 10042613 - Surgical and medical procedures 10063797 Cataract operation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000980-42 Sponsor Protocol Number: V1.1/13.05.2014 Start Date*: 2014-09-26
    Sponsor Name:Medical University Vienna
    Full Title: Feasibility and safety of intensified preoperative glucose control in patients with type 2 diabetes undergoing cardiovascular surgery – a pilot study
    Medical condition: The objective of this study is to investigate whether a targeted preoperative glucose control before planned cardiac surgery by i.v. insulin infusion (intensified glycemic control, ICG) versus st...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003942-33 Sponsor Protocol Number: M13-796 Start Date*: 2013-05-03
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk...
    Medical condition: Acute Kidney Injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004857 10069339 Acute kidney injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-000747-26 Sponsor Protocol Number: KETTO201200047426 Start Date*: 2012-04-27
    Sponsor Name:Helsinki Universiy Central Hospital
    Full Title: Administration of S-Ketamine during spinal surgery to reduce postoperative pain
    Medical condition: adult patients undergoing spinal surgery
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10041595 Spinal stenosis lumbar LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004672-35 Sponsor Protocol Number: PACS2019 Start Date*: 2020-01-10
    Sponsor Name:Institution for Clinical Science, Karolinska Institutet
    Full Title: Open heart surgery – does it have to hurt that much? PACS – Parasternal After Cardiac Surgery. A prospective randomised study to assess the analgesic effect of a continuous bilateral parasternal bl...
    Medical condition: The analgesic effect of continuous bilateral parasternal infusion of local anaesthetic after open cardiac surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000274-36 Sponsor Protocol Number: APACH2 Start Date*: 2019-07-03
    Sponsor Name:Centre François Baclesse
    Full Title: Phase III trial comparing 2 diagnostic strategies for the preoperative localization of parathyroid adenoma in primary hyperparathyroidism: TEMP / CT with Tc99m-sestaMIBI or PET / CT with F18-choli...
    Medical condition: Patient with primary hyperparathyroidism and for which surgical resection is provided.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10014698 - Endocrine disorders 10020705 Hyperparathyroidism PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004213-41 Sponsor Protocol Number: RIPAC Start Date*: 2019-06-12
    Sponsor Name:University Hospital Ghent
    Full Title: Effect of intravenous replenishment of iron in the preoperative management of anemia in patients with colon cancer: RIPAC-trial
    Medical condition: M0-stage colon carcinoma with iron deficiency anemia defined by a Hb lower than 13 g/dl in men and 12g/dl in women with a transferrin saturation lower than 20%
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10009964 Colon carcinoma stage 0 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-002541-11 Sponsor Protocol Number: P170912J Start Date*: 2019-06-06
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Prevention of post-operative Atrial Fibrillation by BOTulinum toxin injections into epicardial fat pads around pulmonary veins in patients undergoing cardiac surgery
    Medical condition: Adult patients with indication for conventional cardiac surgery (CABG, aortic replacement, or ascending aorta surgery) will be eligible
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004865 10067824 Prophylaxis against atrial fibrillation LLT
    Population Age: Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2022-002451-19 Sponsor Protocol Number: 2022-15754 Start Date*: 2022-09-22
    Sponsor Name:Radboudumc
    Full Title: Deep versus moderate neuromuscular blockade during total HIP replacement surgery to improve POstoperative quality of recovery and immune function: a randomized controlled study
    Medical condition: Hip osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001384-27 Sponsor Protocol Number: 2022-031 Start Date*: 2023-02-28
    Sponsor Name:Franciscus Gasthuis & Vlietland
    Full Title: Peroperative Administration of Tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce hemorrhage rates (PATRY study): a randomized controlled trial
    Medical condition: Morbid obesity
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10059610 Obesity surgery LLT
    21.0 100000004861 10027966 Morbid obesity LLT
    21.1 100000004865 10068900 Bariatric surgery LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-005065-31 Sponsor Protocol Number: 9769 Start Date*: 2017-05-09
    Sponsor Name:University hospital of Montpellier
    Full Title: Comparison of preoperative hemoglobin after administration of epoetin alpha associated with oral martial supplementation vs intraveinous martial supplementation before craniosynostosis in children
    Medical condition: Craniosynostosis
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000071-90 Sponsor Protocol Number: AGO/2017/002 Start Date*: 2017-03-15
    Sponsor Name:Ghent University Hospital
    Full Title: Effect of sevoflurane and propofol on hepato-splanchnic pressure and flow during hepatobiliary surgery.
    Medical condition: patients scheduled for hepato-biliary surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-002197-13 Sponsor Protocol Number: ANE_SEVPRO_2016_01 Start Date*: 2017-02-20
    Sponsor Name:Servicio de Anestesiología y Reanimación
    Full Title: IMPLICATION OF TWO ANESTHETIC TECHNIQUES: SEVOFLURANE VERSUS PROPOFOL TO REDUCE BLOOD LOSS IN ORTHOGNATHIC SURGERY
    Medical condition: Assessment of the bleeding in ortognatic surgery.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000506-21 Sponsor Protocol Number: Chumbley1 Start Date*: 2011-06-21
    Sponsor Name:Imperial College Healthcare NHS Trust
    Full Title: A double-blind, randomised placebo-controlled trial to determine whether low-dose intravenous ketamine peri-operatively can prevent chronic post-surgical pain, in patients undergoing thoracotomy or...
    Medical condition: Chronic post-surgical pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-003115-34 Sponsor Protocol Number: V1 Start Date*: 2012-06-06
    Sponsor Name:Medizinische Universität Wien
    Full Title: A Collagen-Fibrin Patch (Tachosil®) for the Prevention of Symptomatic Lymphoceles after Pelvic Lymphadenectomy in Women with Gynecologic Malignancies: a Randomized Clinical Trial
    Medical condition: endometrial cancer, cervical cancer
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2019-003972-37 Sponsor Protocol Number: CLVSPR19 Start Date*: 2020-06-05
    Sponsor Name:Hospital Arnau de Vilanova - Lliria
    Full Title: Comparative study of cloroprocaine versus prilocaine intrathecal anestesia in major ambulatory surgery
    Medical condition: Inguinal hernia liable to ambulatory surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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