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Clinical trials for General anesthesia

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    368 result(s) found for: General anesthesia. Displaying page 7 of 19.
    EudraCT Number: 2004-003819-23 Sponsor Protocol Number: 19.4.306 Start Date*: 2005-04-04
    Sponsor Name:NV Organon
    Full Title: A multi-center, randomized, parallel dose-finding, safety-assessor blinded trial to explore the efficacy, safety and pharmacokinetics of four doses of Org 25969 and placebo in pediatric and adult s...
    Medical condition: not applicable
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: FI (Completed) DE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-000561-20 Sponsor Protocol Number: 020186 Start Date*: 2020-02-28
    Sponsor Name:Tampere University Hospital
    Full Title: Monitoring of neuromuscular blockade during general anaesthesia after reversal with neostigmine
    Medical condition: We are studying reappearence of nondepolarizing neuromuscular block after it has been antagonized with a combination of neostigmine and glycopyrrolate. We are trying to find the incidence of the ph...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-002519-40 Sponsor Protocol Number: CHL.2/01-2014/M Start Date*: 2015-08-17
    Sponsor Name:Sintetica S.A.
    Full Title: A prospective, randomised, non-inferiority study of Chloroprocaine 2% and the active control Ropivacaine 0.75% (AstraZeneca) in ultrasound-guided axillary nerve block for short-duration distal uppe...
    Medical condition: Local anaesthesia by axillary nerve block
    Disease: Version SOC Term Classification Code Term Level
    19.1 10042613 - Surgical and medical procedures 10024758 Local anaesthesia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-004604-29 Sponsor Protocol Number: 210710120713 Start Date*: 2015-04-27
    Sponsor Name:Jens Rolighed Larsen
    Full Title: Sevoflurane versus standard general anesthesia in elective open abdominal aortic aneurism surgery
    Medical condition: Abdominal aortic aneurism
    Disease: Version SOC Term Classification Code Term Level
    18.0 10042613 - Surgical and medical procedures 10002885 Aortic aneurysm repair PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000202-75 Sponsor Protocol Number: P.Sitsen.03 Start Date*: 2007-06-15
    Sponsor Name:Leids Universitair Medisch Centrum
    Full Title: A comparison of the efficacy of levobupivacaine 0,125%, ropivacaine 0,125% and ropivacaine 0,2%, all combined with sufentanil 0.5 micrograms/mL, in patient-controlled epidural analgesia after hyste...
    Medical condition: Primary Objective •to compare the analgesic efficacy of levobupivacaine and ropivacaine in patient-controlled epidural analgesia, as assessed by the number of requests for epidural bolus injections...
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000709-55 Sponsor Protocol Number: SugaRoc Start Date*: 2020-04-01
    Sponsor Name:Universitair Ziekenhuis Brussel
    Full Title: Sugammadex dose-finding study for reversal of deep rocuronium-induced neuromuscular block
    Medical condition: decurarisation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2004-004728-11 Sponsor Protocol Number: MR/EUM202 Start Date*: 2005-03-25
    Sponsor Name:Avera Pharmaceuticals Inc.
    Full Title: A Multicenter, Randomized, Controlled, Observer-Blinded, Dose-Response Study to Evaluate The Efficacy in Tracheal Intubation and Safety of Gantacurium Chloride for Injection in Healthy Adult Patien...
    Medical condition: Adjunct to anesthesia to facilitate tracheal intubation (non-depolarizing neuromuscular blocking agent)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006632-67 Sponsor Protocol Number: CHUBX2021/36 Start Date*: 2022-03-14
    Sponsor Name:CHU de Bordeaux
    Full Title: Alkalinization of adrenalized lidocaine in extending epidural analgesia for extremely urgent cesarean section during labor: a randomized controlled trial.
    Medical condition: epidural analgesia for extremely urgent cesarean
    Disease: Version SOC Term Classification Code Term Level
    20.0 10036585 - Pregnancy, puerperium and perinatal conditions 10036585 Pregnancy, puerperium and perinatal conditions SOC
    Population Age: Adults Gender: Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001021-22 Sponsor Protocol Number: NKO101287 Start Date*: 2005-02-08
    Sponsor Name:GlaxoSmithKline Research and Development Limited
    Full Title: A Multicentre, Randomised, Double-blind, Double-dummy, Placebo-controlled, Parallel Group, Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Oral (25 mg) and Intravenous (3 m...
    Medical condition: Post Operative Nausea and Vomiting (PONV) Post Discharge Nausea and Vomiting (PDNV)
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: FI (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-001146-29 Sponsor Protocol Number: 1 Start Date*: 2016-01-12
    Sponsor Name:Hospital Central de la Defensa
    Full Title: Selective local anesthesia versus a combined medication injection with corticosteroids in degenerartive spine
    Medical condition: Degenerative spine pain when there are no indications for surgical treatment
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005337-31 Sponsor Protocol Number: CHUB-fluides Start Date*: 2015-02-23
    Sponsor Name:CHU Brugmann
    Full Title: Crystalloids or colloids for goal-directed fluid therapy with closed-loop assistance in major surgery?
    Medical condition: Major abdominal surgery, by laporotomy.
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004867 10065498 Infusion site anesthesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-002842-35 Sponsor Protocol Number: 2018/07 Start Date*: 2018-11-07
    Sponsor Name:CMC Ambroise Paré
    Full Title: Interest of parasternal block to prevent hypertensive and tachycardia episodes during sternotomy in patients undergoing coronary artery bypass graft
    Medical condition: coronary artery bypass graft
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-024225-20 Sponsor Protocol Number: 301110_PALANCE Start Date*: 2014-08-22
    Sponsor Name:University Hospital Munich, Germany
    Full Title: The impact of phosphate balanced cristalloid infusion on acid-base homeostastis
    Medical condition: This study aims to investigate a new crystalloid fluid therapy regime for the perioperative setting providing stable fluid and acid-base homeostasis in the patient.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-003689-37 Sponsor Protocol Number: RC20_0319 Start Date*: 2020-10-27
    Sponsor Name:CHU de Nantes
    Full Title: REmimazolam infusion in the context of Hypnotic Shortage in the Critical care Unit during the pandemic of COVID-19. The non-randomized, non-controlled, pilot, open, mono-centric REHSCU study.
    Medical condition: general anaesthesia in ICU
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10021723 Induction and maintenance of anaesthesia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-023159-27 Sponsor Protocol Number: MGR-LB-2010-01 Start Date*: 2011-09-19
    Sponsor Name:MANUEL ÁNGEL GÓMEZ RÍOS
    Full Title: EFICACIA DE LA INFUSIÓN CONTINUA DE LEVOBUPIVACAINA EN LA HERIDA QUIRÚRGICA TRAS CESÁREA
    Medical condition: Analgesia postoperatoria en gestantes sometidas a cesárea bajo anestesia intradural
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029205 - Nervous system disorders 10020573 Hyperalgesia LLT
    14.0 10042613 - Surgical and medical procedures 10024760 Local anesthetic LLT
    14.0 10018065 - General disorders and administration site conditions 10066714 Acute pain LLT
    14.0 10042613 - Surgical and medical procedures 10052673 Wound irrigation LLT
    14.0 10018065 - General disorders and administration site conditions 10049475 Chronic pain LLT
    Population Age: Adults Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004587-11 Sponsor Protocol Number: KUKIDEX-1 Start Date*: 2016-01-08
    Sponsor Name:University Medical Center Groningen
    Full Title: Safety, tolerability and sedative properties of single dose intranasal dexmedetomidine premedication in elderly subjects.
    Medical condition: Anxiety, preoperative
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004982-10 Sponsor Protocol Number: LOC-2016 Start Date*: 2015-12-15
    Sponsor Name:Harry Scheinin
    Full Title: The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
    Medical condition: No medical condition or disease involved. The study subjects are healthy volunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005156-26 Sponsor Protocol Number: PRIN-SUGAR-2014 Start Date*: 2015-05-27
    Sponsor Name:Dr. Enrique Alday
    Full Title: Effects of neuromuscular block reversal with sugammadex vs neostigmine on postoperative respiratory outcomes after major abdominal surgery. A randomized controlled trial.
    Medical condition: Patients of both sexes proposed for major abdominal surgery under general anesthesia plus epidural
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018276-25 Sponsor Protocol Number: 20100901 Start Date*: 2010-12-16
    Sponsor Name:Medizinische Universität Wien
    Full Title: Effects of intravenous Lidocaine on MAC of Sevoflurane
    Medical condition: The effects of intravenous application of Lidocaine on the MAC during Sevofluran Narcosis should will be investigated
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-000298-20 Sponsor Protocol Number: CHL.3/01-2016 Start Date*: 2016-10-18
    Sponsor Name:Sintetica S.A.
    Full Title: Comparison of epidural Chloroprocaine 3% and Ropivacaine 0.75% for unplanned Caesarean section in labouring women who have an epidural catheter in situ
    Medical condition: Local epidural anaesthesia in labouring women who have an epidural catheter in situ and established analgesia and need unplanned Caesarean
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10024758 Local anaesthesia PT
    Population Age: Adults Gender: Female
    Trial protocol: BE (Prematurely Ended) DE (Prematurely Ended) AT (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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