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Clinical trials for Angiotensin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43871   clinical trials with a EudraCT protocol, of which   7290   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    347 result(s) found for: Angiotensin. Displaying page 1 of 18.
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    EudraCT Number: 2013-004460-66 Sponsor Protocol Number: KARAASS-1 Start Date*: 2014-04-01
    Sponsor Name:Jørgen Jeppesen
    Full Title: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system
    Medical condition: Blood pressure regulation and hypertension
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004866 10008393 Change in blood pressure LLT
    16.1 100000004865 10053967 Potassium supplementation LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2020-001172-15 Sponsor Protocol Number: APN01-01-COVID19 Start Date*: 2020-04-08
    Sponsor Name:APEIRON Biologics AG
    Full Title: Recombinant human angiotensin-converting enzyme 2 (rhACE2) as a treat-ment for patients with COVID-19
    Medical condition: Severe COVID-19 POSITIVE hospitalized male or female, between 18 and ≤ 80 years of age
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) DK (Completed) AT (Completed) GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2012-000250-55 Sponsor Protocol Number: RASQAL Start Date*: 2012-07-12
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für innere Medizin III
    Full Title: Renin-Angiotensin System Quantification in patients treated with Aliskiren or Candesartan (RASQAL)
    Medical condition: - Chronic kidney disease stages III-IV (defined by MDRD formula) - Hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-003568-20 Sponsor Protocol Number: RGR Start Date*: 2008-08-08
    Sponsor Name:Prof Alice Stanton
    Full Title: Renin Genotype and Response to Renin Angiotensin System Blockade.
    Medical condition: Hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: View results
    EudraCT Number: 2007-000727-17 Sponsor Protocol Number: 281274 Start Date*: 2007-08-23
    Sponsor Name:Erasmus MC
    Full Title: Maternal, uteroplacental and fetal haemodynamic effect of Nicardipine in severe pre-eclampsia.
    Medical condition: Hypertensive crisis in patients with severe pre-eclampsia needs to be treated to prevent maternal and fetal complications. The maternal, uteroplacental and fetal haemodynamic respose to antihypert...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10040445 Severe pre-eclampsia, antepartum LLT
    9.1 10053094 Doppler echocardiography LLT
    9.1 10045412 Ultrasound Doppler LLT
    9.1 10058179 Hypertensive emergency LLT
    9.1 10038555 Renin LLT
    9.1 10002491 Angiotensin II LLT
    9.1 10053406 Brain natriuretic peptide LLT
    9.1 10001644 Aldosterone LLT
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-001267-11 Sponsor Protocol Number: Jens05 Start Date*: 2008-09-29
    Sponsor Name:Department of Nephrology
    Full Title: Saving residual kidney function among haemodialysis patients receiving irbesartan - a double blind randomised study
    Medical condition: We want to investigate if an angiotensin II antagonist (irbesartan) has beneficial effects regarding residual kidney function and heart/vessels among haemodialysis patients.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10049415 Renin-angiotensin system inhibition LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2007-000452-14 Sponsor Protocol Number: FARM537JNE Start Date*: 2007-08-29
    Sponsor Name:CONSORZIO MARIO NEGRI SUD
    Full Title: Long term impact of renin angiotensin system RAS inhibition on cardiorenal outcomes. A randomized controlled trial of cardio-renal effects of RAS inhibition in patients with cardio-renal risk. A...
    Medical condition: Patients with one or more cardiovascular risk factors and microalbuminuria, diabetic or not diabetic.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10027525 Microalbuminuria LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-001738-29 Sponsor Protocol Number: RGHT000502 Start Date*: 2009-03-20
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Renin angiotensin Aldosterone (RAAS) axis, endothelial function and hypertension: diagnostic strategies and therapeutic role of potassium supplementation
    Medical condition: We are seeking to determine the effects of potassium supplementation vs placebo for 6 weeks on the renin-angiotensin-aldosterone axis and also endothelial function in subjects with 10-20% 10 year ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-012676-27 Sponsor Protocol Number: FemExp-I Start Date*: 2010-01-24
    Sponsor Name:Wallenberg laboratory
    Full Title: Femoral-Express-I
    Medical condition: Peripheral artery disease. Patients due for by-pass surgery of lower extremity arteries.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10034638 Peripheral vascular disorders NEC HLT
    12.0 10003611 Atherosclerosis of arteries of the extremities, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007881-45 Sponsor Protocol Number: SPP100ANL02T Start Date*: 2009-03-12
    Sponsor Name:University Medical Center Groningen
    Full Title: A double-blind, placebo-controlled, randomized trial investigating the safety and efficacy of Additive Renin Inhibition with Aliskiren on renal blood flow and Neurohormonal Activation in patients w...
    Medical condition: Patients with chronic heart failure and reduced glomerular filtration rate.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10038443 Renal failure and impairment HLT
    9.1 10008908 Chronic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-004141-90 Sponsor Protocol Number: 4.0 Start Date*: 2017-02-28
    Sponsor Name:Queen Mary University of London
    Full Title: Stopping Perioperative Angiotensin II Converting Enzyme inhibitors and/or receptor blockers in major non-cardiac surgery (SPACE): a phase II, explanatory, randomised controlled trial.
    Medical condition: Myocardial injury (as measured by plasma troponin) after major surgery.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10061024 Cardiac disorder PT
    20.0 10007541 - Cardiac disorders 10061024 Cardiac disorder PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2013-002091-41 Sponsor Protocol Number: 03618 Start Date*: 2014-10-09
    Sponsor Name:Academisch medisch centrum
    Full Title: Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system
    Medical condition: To study the effect of losartan in adult patients with Tetralogy of Fallot and right ventricular dysfunction, defined as right ventricular ejection fraction <50%. Without severe valvular lesions.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-016600-23 Sponsor Protocol Number: 05102009 Start Date*: 2010-07-09
    Sponsor Name:Hull and East Yorkshire Hospitals NHS Trust
    Full Title: A double blind, randomised, placebo controlled trial to study the clinical effectiveness of Angiotensin Converting Enzyme (ACE) inhibitors, ramipril,in patients with intermittent claudication
    Medical condition: Intermittent Claudication
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-003175-19 Sponsor Protocol Number: U1111-1206-7541 Start Date*: 2019-11-28
    Sponsor Name:Steno Diabetes Center Copenhagen
    Full Title: Renal effects of treatment with Empagliflozin alone or in combination with Semaglutide in patients with type 2 diabetes and albuminuria - A double blinded, randomised, placebo controlled, parallel...
    Medical condition: Type 2 diabetes with renal complications
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004861 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000213-23 Sponsor Protocol Number: NL60561.078.17 Start Date*: 2017-07-21
    Sponsor Name:
    Full Title: ARNI-study: ARNI or ARB to arrest progression of nephropathy.
    Medical condition: Chronic kidney disease with concurrent hypertension and diabetes.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006861-18 Sponsor Protocol Number: 20061212 Start Date*: 2007-03-26
    Sponsor Name:Department of Cardiology
    Full Title: Comparison between beta-adrenergic blockers and angiotensin II receptor antagonists for the treatment of late hypertension in patients with repaired aortic coarctation
    Medical condition: Aortic coarctation and late hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-003262-17 Sponsor Protocol Number: AG-1-2007. Start Date*: 2008-08-13
    Sponsor Name:University Hospital Magdeburg
    Full Title: Impact of irbesartan on oxidative stress and C-reactive protein levels in patients with persistent atrial fibrillation
    Medical condition: Blocking the angiotensin II type 1 receptor reduces systemic levels of oxidative stress markers and adhesion molecules compared to placebo in patients with persistent/permanent atrial fibrillation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-002431-80 Sponsor Protocol Number: LEV1068 Start Date*: 2006-09-15
    Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA
    Full Title: Renal Effects of Levosimendan in Patients Admitted with Acute Decompensated Heart Failure
    Medical condition: Patients with acute decompensated heart failure.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10060953 Ventricular failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003637-96 Sponsor Protocol Number: NL54748.078.15 Start Date*: 2016-03-31
    Sponsor Name:
    Full Title: DD-study: diet or diuretics for salt-sensitivity in chronic kidney disease
    Medical condition: Hypertension in chronic kidney disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-002262-19 Sponsor Protocol Number: CVAL489ANL09 Start Date*: 2006-08-07
    Sponsor Name:Novartis Pharma B.V.
    Full Title: Angiotensin II receptor blockers in patients with systemic right ventricle.
    Medical condition: Systemic right ventricle due to total transposition of the great arteries or congenitally corrected transposition of the great arteries
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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