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Clinical trials for Antifibrinolytic

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    12 result(s) found for: Antifibrinolytic. Displaying page 1 of 1.
    EudraCT Number: 2004-002955-14 Sponsor Protocol Number: ISRCTN86750102 Start Date*: 2008-07-28
    Sponsor Name:London School of Hygiene and Tropical Medicine [...]
    1. London School of Hygiene and Tropical Medicine
    2. World Health Organisation
    Full Title: A large randomised placebo controlled trial among trauma patients with or at risk of significant haemorrhage, of the effects of antifibrinolytic treatment on death and transfusion requirement
    Medical condition: Haemorrhage following Trauma
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) BE (Completed) SK (Completed) PT (Ongoing) PL (Completed)
    Trial results: View results
    EudraCT Number: 2016-000071-24 Sponsor Protocol Number: TRANEXTIME Start Date*: 2016-03-10
    Sponsor Name:Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR)
    Full Title: TIME OF ADMINISTRATION OF TRANEXAMIC ACID TO PREVENT BLEEDING IN TOTAL KNEE ARTHROPLASTY
    Medical condition: Total knee arthroplasty bleeding
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006324-62 Sponsor Protocol Number: NN1810-3540 Start Date*: 2009-04-16
    Sponsor Name:Novo Nordisk A/S
    Full Title: A Multi-Centre, Randomised, Double-Blind, Placebo Controlled Trial on Efficacy and Safety of FXIII Replenishment with two different Doses of Recombinant Factor XIII following Cardiopulmonary Bypass...
    Medical condition: Aquired FXIII deficiency following cardiopulmonary bypass surgery (CABG (coronary atery bypass grafting) or CABG plus single heart valve replacement/repairs or planned replacement/repair of a singl...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063919 Bypass surgery LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) DK (Completed) ES (Completed) GB (Completed) IT (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-005824-13 Sponsor Protocol Number: MEIN/12/Bil-Ang/001 Start Date*: 2013-03-23
    Sponsor Name:Menarini International Operation Luxembourg SA
    Full Title: Pilot study on efficacy of bilastine in preventing angioedema symptoms in patients with angioedema of unknown etiology (idiopathic angioedema, IAE)
    Medical condition: idiopathic angioedema
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2022-002384-30 Sponsor Protocol Number: ABR81872 Start Date*: 2022-11-15
    Sponsor Name:Erasmus MC - Sophia
    Full Title: Reduction of blood loss in pediatric osteotomies around the hip - A randomized placebo-controlled trial with tranexamic acid –
    Medical condition: Osteotomies around the hip, i.e. proximal femoral and/or pelvic osteotomies (PFPO) in children, for e.g: - hip dysplasia - secondary hip dysplasia - hip incongruenties due to other problems (e.g. p...
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001381-38 Sponsor Protocol Number: 1 Start Date*: 2021-08-30
    Sponsor Name:Plastikkirurgisk og brystkirurgisk afdeling, Region Sjælland
    Full Title: Topical use of tranexamic acid for optimisation of wound healing in a novel, acute wound model
    Medical condition: Immunomodulation of postoperative inflammatory reactions and thereby reduction of wound fluid production and improved healing by topical administration of tranexamic acid.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10002784 Antifibrinolysis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-005592-12 Sponsor Protocol Number: 76873 Start Date*: 2021-08-30
    Sponsor Name:Plastikkirurgisk og brystkirurgisk afdeling, Region Sjælland
    Full Title: The effect of tranexamic acid on seroma formation after mastectomies
    Medical condition: Immunomodulation of postoperative inflammatory reactions and thereby reduction of wound seroma by topical administration of tranexamic acid.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10002784 Antifibrinolysis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-007813-35 Sponsor Protocol Number: TBA Start Date*: 2008-06-16
    Sponsor Name:University Hospital of North Tees and Hartlepool
    Full Title: Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Cemented Total Knee Replacement (TRANX-K).
    Medical condition: In this study Tranexamic acid efficacy in reducing blood loss will be investigated in total knee replacement.Tranexamic acid will be applied topically to the exposed tissue around the knee joint pr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023227 Joint replacement LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-008441-38 Sponsor Protocol Number: ISRCTN76912190 Start Date*: 2011-02-17
    Sponsor Name:London School Of Hygiene and Tropical Medicine
    Full Title: Tranexamic acid for the treatment of postpartum haemorrhage: An international randomised, double blind, placebo controlled trial
    Medical condition: Postpartum haemorrhage
    Disease: Version SOC Term Classification Code Term Level
    13.1 10036417 Post-partum haemorrhage LLT
    Population Age: Adolescents, Under 18, Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-004666-15 Sponsor Protocol Number: TMC-MDC-11-01 Start Date*: 2012-04-03
    Sponsor Name:The Medicines Company
    Full Title: A Phase II, double-blind, parallel group, dose-selection study to compare antifibrinolytic MDCO-2010 vs. placebo and tranexamic acid in reducing blood loss in patients undergoing primary cardiac su...
    Medical condition: Primary cardiac surgery involving cardiopulmonary bypass
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-003232-24 Sponsor Protocol Number: AVA-PED-301 Start Date*: 2020-12-03
    Sponsor Name:Dova Pharmaceuticals, Inc.
    Full Title: A Phase 3b, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Avatrombopag for the Treatment...
    Medical condition: Thrombocytopenia in paediatric subjects with immune thrombocytopenia for ≥6 months duration who have had an insufficient response to a previous treatment
    Disease: Version SOC Term Classification Code Term Level
    20.0 10005329 - Blood and lymphatic system disorders 10043555 Thrombocytopenias HLT
    23.0 10005329 - Blood and lymphatic system disorders 10083843 Primary immune thrombocytopenia LLT
    23.0 10005329 - Blood and lymphatic system disorders 10083842 Immune thrombocytopenia PT
    20.0 10005329 - Blood and lymphatic system disorders 10035534 Platelet disorders HLGT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Completed) HU (Ongoing) DE (Ongoing) PL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-005650-54 Sponsor Protocol Number: MD2011.01 Start Date*: 2012-06-04
    Sponsor Name:University Medical Center Groningen
    Full Title: Prothrombin complex concentrate in the reduction of blood loss during otrhotopic liver transplantation.
    Medical condition: liver cirhosis coagulopathy bleeding
    Disease: Version SOC Term Classification Code Term Level
    14.1 10005329 - Blood and lymphatic system disorders 10009802 Coagulopathy PT
    14.1 10042613 - Surgical and medical procedures 10024716 Liver transplantation LLT
    14.1 10022891 - Investigations 10049227 Bleeding time abnormal PT
    14.1 10019805 - Hepatobiliary disorders 10024667 Liver cirrhosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Ongoing) NL (Ongoing) BE (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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