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Clinical trials for Aprotinin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    16 result(s) found for: Aprotinin. Displaying page 1 of 1.
    EudraCT Number: 2005-003053-26 Sponsor Protocol Number: TMC-BIV-05-01 Start Date*: 2005-12-08
    Sponsor Name:The Medicines Company UK Ltd
    Full Title: The ZBMUF trial: an open-label randomised study of the effects of ultra-filtration and high dose aprotinin on bivalirudin pharmacokinetics during and/or after cardiopulmonary bypass surgery
    Medical condition: This trial will involve approximately 42 patients requiring coronary artery bypass graft surgery (CABG).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-004689-18 Sponsor Protocol Number: Bay a 0128/11800 Start Date*: 2006-06-28
    Sponsor Name:Bayer Inc.
    Full Title: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Design, 2-Arm Study to Investigate the Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Surgical Procedu...
    Medical condition: Thoracic surgery in patient with lung or esophageal cancer
    Disease: Version SOC Term Classification Code Term Level
    8.1 10057191 Transfusion related complications HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) DK (Prematurely Ended) ES (Prematurely Ended) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003999-38 Sponsor Protocol Number: Bay a 0128/11799 Start Date*: 2006-04-06
    Sponsor Name:Bayer Pharmaceuticals Corporation
    Full Title: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Design, 2-Arm Study to Investigate the Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal ...
    Medical condition: Elective Spinal Fusion Surgery
    Disease: Version SOC Term Classification Code Term Level
    8.1 10057191 Transfusion related complications HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-004055-35 Sponsor Protocol Number: Bay a 0128/12002 Start Date*: 2006-01-02
    Sponsor Name:Bayer HealthCare AG
    Full Title: A multi-center, randomized, double blind, placebo controlled study to investigate the efficacy and safety of Aprotinin on transfusion requirements in patients with bladder cancer undergoing radical...
    Medical condition: Radical or total cystectomy on patients with bladder cancer
    Disease: Version SOC Term Classification Code Term Level
    8.1 10057191 Transfusion related complications HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) BE (Completed) SE (Prematurely Ended) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-002434-33 Sponsor Protocol Number: Aprotinin1.0. Start Date*: 2020-10-16
    Sponsor Name:Hospital General Universitario Ciudad Real
    Full Title: Phase 3 randomized study to evaluate the safety and efficacy of aprotinin (Trasylol®) administered by inhalation nebulization in patients diagnosed with SARS-CoV-2 (COVID-19) with moderate severity...
    Medical condition: Patients with moderate SARS-CoV-2 pneumonia confirmed with a diagnosis of polymerase chain reaction (PCR) before randomization. The patient should be hospitalized and require ongoing medical care f...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-002652-42 Sponsor Protocol Number: 2007IC007H Start Date*: 2007-08-14
    Sponsor Name:Royal Brompton and Harefield NHS Trsut
    Full Title: The use of clopidogrel and aprotonin in off pump coronary artery bypass grafting
    Medical condition: Bleeding after coronary artery bypass grafting
    Disease: Version SOC Term Classification Code Term Level
    9.1 10005645 Blood loss of (NOS) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-018480-42 Sponsor Protocol Number: 550904 Start Date*: 2010-11-12
    Sponsor Name:Baxter Innovations GmbH
    Full Title: A RANDOMIZED, CONTROLLED, MULTICENTER PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FIBRIN SEALANT VH S/D 500 S-APR (TISSEEL) FOR HEMOSTASIS IN SUBJECTS UNDERGOING HEPATIC RESECTION
    Medical condition: Hemostasis in hepatic resection
    Disease: Version SOC Term Classification Code Term Level
    13.1 10042613 - Surgical and medical procedures 10060663 Surgical hemostasis LLT
    13.1 10042613 - Surgical and medical procedures 10067440 Hemostasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-017804-95 Sponsor Protocol Number: ATRHEMOS/1 Start Date*: 2010-03-05
    Sponsor Name:Fundació Institut de Recerca de l?Hospital de la Santa Creu i Sant Pau
    Full Title: Prevención del sangrado postoperatorio: Ensayo clínico unicéntrico, aleatorizado, paralelo y controlado que evalúa la eficacia de la cola de fibrina y el ácido tranexámico en pacientes intervenidos...
    Medical condition: Pacientes que precisan de una artroplastia de rodilla. Patients with are needed of an arthroplasty of the knee.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-004113-96 Sponsor Protocol Number: AGO/2008/008 Start Date*: 2008-09-17
    Sponsor Name:University Hospital Ghent
    Full Title: DRainage versus sEAlant in prospective, Monocentric, double blinded randomized trial to evaluate the effect of fibrin glue in surgical repair of incisional hernias (DREAM-trial)
    Medical condition: Open incisional hernia mesh repair
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005535-40 Sponsor Protocol Number: 3599-001 Start Date*: 2016-07-21
    Sponsor Name:Baxter Healthcare Corporation
    Full Title: A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated (FS VH S/D 500 s-apr) Compared to DuraSeal Dural Sealant as an Adjunct ...
    Medical condition: Intra-operative CSF leak
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10024091 Leakage of cerebrospinal fluid LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-002328-34 Sponsor Protocol Number: KB056 Start Date*: Information not available in EudraCT
    Sponsor Name:KEDRION S.P.A
    Full Title: Efficacy and safety evaluation of Kedrion Fibrin Sealant as an adjuvant for the control of hemostasis in pediatric patients undergoing abdominal or orthopedic surgery. Multicenter, randomized, cont...
    Medical condition: Paediatric patients undergoing abdominal or orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    18.0 10042613 - Surgical and medical procedures 10067439 Haemostasis PT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-001739-28 Sponsor Protocol Number: S63979 Start Date*: 2020-05-20
    Sponsor Name:UZLeuven
    Full Title: A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19.
    Medical condition: COVID-19
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10038700 Respiratory infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-003006-98 Sponsor Protocol Number: PROT-TISSUCOL-001 Start Date*: 2007-07-16
    Sponsor Name:Cirugía General II. Hospital General Universitario “Gregorio Marañón”
    Full Title: ESTUDIO FASE IV, UNICENTRICO, ALEATORIZADO, SIMPLE CIEGO, CONTROLADO, COMPARATIVO DE DOS GRUPOS PARALELOS PARA EVALUAR LA EFICACIA DE TISSUCOL DUO (ADHESIVO BIOLOGICO A BASE DE FIBRINA) EN LA PREVE...
    Medical condition: Defectos de cicatrización (fístulas, dehiscencias y fugas subclínicas) en la(s) anastomosis(s) de tubo digestivo de alto riesgo: Las anastomosis consideradas de alto riesgo son: 1. Anastomosis rect...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058066 Perforation of anastomosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001340-21 Sponsor Protocol Number: KB046 Start Date*: 2013-01-15
    Sponsor Name:KEDRION
    Full Title: A Historically-Controlled Phase II/III study to Evaluate Efficacy and Safety of Kedrion Human Plasminogen Eye Drop Preparation in Patients Diagnosed with Ligneous Conjunctivitis
    Medical condition: Ligneous Conjunctivitis ( MedDRA Code vers. 15.0: 10071570 LLT - no present in OsSC database) associated with Type I Plasminogen Deficiency
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2006-004866-14 Sponsor Protocol Number: Start Date*: 2006-10-09
    Sponsor Name:TAYS
    Full Title: Aprotiinin keuhkojen toimintaa suojaava vaikutus sydänleikkauksissa
    Medical condition: ohitusleikkaus
    Disease: Version SOC Term Classification Code Term Level
    8.1 10011098 Coronary bypass LLT
    Population Age: Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-002741-39 Sponsor Protocol Number: TIMELI001 Start Date*: 2005-12-07
    Sponsor Name:Prof. Giampiero CAMPANELLI
    Full Title: A prospective, controlled, randomized, patient and evaluator blinded study to evaluate pain and further disabling complications in patients undergoing Lichtenstein technique for primary inguinal he...
    Medical condition: Unilateral, uncomplicated primary inguinal hernia repair
    Disease: Version SOC Term Classification Code Term Level
    10022020
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed) DE (Completed) ES (Completed) DK (Completed) IT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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