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Clinical trials for Biofilm

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    17 result(s) found for: Biofilm. Displaying page 1 of 1.
    EudraCT Number: 2020-003444-80 Sponsor Protocol Number: 2020-01471 Start Date*: 2020-11-17
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: Evaluation of the clinical implementation of biofilm susceptibility to antibiotics using Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC) to gu...
    Medical condition: Periprosthetic hip or knee joint infections
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-000131-51 Sponsor Protocol Number: 1921 Start Date*: 2019-03-07
    Sponsor Name:Zealand University Hospital
    Full Title: Preoperative endoscopic treatment with fosfomycin and metronidazole in patients with right-sided colon cancer and colon adenoma: a clinical proof-of-concept intervention study MEFO trial
    Medical condition: Colon cancer in track 1. Colon adenoma in track 2.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10009944 Colon cancer PT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10048832 Colon adenoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-002192-40 Sponsor Protocol Number: periodld001 Start Date*: 2006-07-13
    Sponsor Name:Zsolt Lohinai DMD PhD
    Full Title: New treatment of periodontitis by inhibition of lysine decarboxilase enzyme
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002239-27 Sponsor Protocol Number: RAM-LIG-2019-01 Start Date*: 2019-09-24
    Sponsor Name:Clinica Dental AndreuDental
    Full Title: Study on the relationship between periodontal disease and serum levels of ultrasensitive Reactive C-Protein and fibrinogen
    Medical condition: Patients with a diagnosis of periodontitis: There is interdental LCI in two or more non-adjacent teeth, or two or more teeth have a vestibular LCI ≥ 3 with a PD > 3 mm
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000869-20 Sponsor Protocol Number: DC0071-BB-404-8B Start Date*: 2005-08-08
    Sponsor Name:Pierre Fabre Médicament
    Full Title: Post-operative care by chlorhexidine mouthwash after periodontal surgery. Randomised, parallel groups; blind study, DC071BB versus placebo, in patients presenting with periodontal surgery with sutu...
    Medical condition: Post-operative care for patients having periodontal surgery with gingival suture.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) EE (Completed) LV (Completed)
    Trial results: View results
    EudraCT Number: 2020-000758-81 Sponsor Protocol Number: Chlorhex-KKDS-2021 Start Date*: 2021-04-08
    Sponsor Name:Karolinska Institutet
    Full Title: Chlorhexidine gluconate as treatment and prophylaxis of vulvovaginal Candidiasis
    Medical condition: Candida vulvovaginitis
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001697-42 Sponsor Protocol Number: OML-III-A Start Date*: 2017-08-30
    Sponsor Name:Schülke & Mayr GmbH
    Full Title: Randomized, placebo-controlled, parallel group, double-blind, multi-center Phase III study to assess the inhibition of plaque formation of 0.1% octenidine mouthwash vs placebo in subjects with a gi...
    Medical condition: inhibition of plaque formation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10056984 Dental plaque PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-023529-39 Sponsor Protocol Number: RHM CHI 0548 Start Date*: 2011-02-18
    Sponsor Name:Southampton University Hopsitals NHS Trust
    Full Title: Reducing antibiotic tolerance using low dose nitric oxide in cystic fibrosis – a phase 2 pilot study
    Medical condition: Cystic Fibrosis
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-001109-15 Sponsor Protocol Number: BIOTOB Start Date*: 2015-12-15
    Sponsor Name:INSTITUTO DE INVESTIGACION SANITARIA LA FE
    Full Title: A Phase III clinical trial randomized and blinded on the use of inhaled tobramycin compared with placebo in patients undergoing mechanical ventilation and colonized by Gram negative bacteria for ef...
    Medical condition: critically ill patients undergoing mechanical ventilation
    Disease: Version SOC Term Classification Code Term Level
    18.1 10022117 - Injury, poisoning and procedural complications 10066821 Mechanical ventilation complication PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-004162-13 Sponsor Protocol Number: SAE-13/IBD Start Date*: 2007-02-27
    Sponsor Name:Charité Universitätsmedizin, Campus Charité Mitte
    Full Title: Randomized, double-blind, placebo-controlled phase II pilot study of the impact of mesalazine enemas on the mucosal gut flora in patients with inflammatory bowel disease
    Medical condition: Active inflammatory bowel disease, i.e. either left-sided ulcerative colitis or Crohn´s Disease (Colon) with signs of inflammation within 40 cm ab ano.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10021972 Inflammatory bowel disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-003541-15 Sponsor Protocol Number: 2019-Fungi Start Date*: 2020-02-19
    Sponsor Name:Aarhus University
    Full Title: Adjunct effect of fluconazole in the treatment of Candida-associated refractory severe periodontitis – A single-center, placebo-controlled, triple blind, randomized clinical trial
    Medical condition: Periodontitis. The participants are in good general health, but have at least 2 residual dental lesions after periodontal treatment (standard care).
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004862 10009102 Chronic periodontitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-001367-36 Sponsor Protocol Number: DoxP-01/2006 Start Date*: 2006-12-05
    Sponsor Name:Prof. Dr. Peter Eickholz
    Full Title: Benefit of adjunctive systemic postsurgical doxycycline in regenerative periodontal surgery
    Medical condition: Periodontitis is an opportunistic infectious disease that destroys the periodontal attachment and bone. Bacterial plaque (biofilm) on the teeth adjacent to the gingiva is the necessary cause gingiv...
    Disease: Version SOC Term Classification Code Term Level
    8.1 10034539 Periodontitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2017-001698-18 Sponsor Protocol Number: OML-III-B Start Date*: 2017-11-06
    Sponsor Name:Schülke & Mayr GmbH
    Full Title: Randomized, placebo-controlled, parallel group, double-blind, multi-center Phase III study to assess the inhibition of plaque formation of 0.1% octenidine mouthwash vs placebo in subjects with a gi...
    Medical condition: inhibition of plaque formation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10056984 Dental plaque PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-000260-17 Sponsor Protocol Number: Intermed_Chlorhexidine_sol_0.2%_ Start Date*: 2012-09-07
    Sponsor Name:IOULIA & IRENE TSETI PHARMACEUTICAL LABORATORIES S.A.-INTERMED S.A.
    Full Title: A therapeutic equivalence study, comparing two chlorhexidine digluconate formulations, the test formulation Chlorel® Or. T. Sol. 0,2% w / v and the reference formulation Corsodyl® 0.2% w / v Mint M...
    Medical condition: Therapeutic equivalence study, comparing two chlorhexidine digluconate formulations indicated for inhibition of the formation of dental plaque, as an aid in the treatment and prevention of gingivi...
    Disease: Version SOC Term Classification Code Term Level
    15.0 10042613 - Surgical and medical procedures 10063390 Oral hygiene LLT
    15.0 10017947 - Gastrointestinal disorders 10058078 Tooth plaque LLT
    15.0 10021881 - Infections and infestations 10018294 Gingivitis infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: View results
    EudraCT Number: 2018-001207-37 Sponsor Protocol Number: HUB-IDIBELL-SAFO-4.3.1 Start Date*: 2019-04-26
    Sponsor Name:Miquel Pujol i Rojo ( Servicio de Enfermedades Infecciosas del Hospital Universitari de Bellvitge
    Full Title: Phase IV-III Clinical Trial, randomized, controlled, open and multicentric, with parallel groups, to evaluate the efficacy of Cloxacillin and fosfomycin combination versus Cloxacillin monotherapy i...
    Medical condition: Methicilin-susceptible S.aureus bacteraemia.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10058863 Staphylococcus aureus bacteraemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-002390-13 Sponsor Protocol Number: notapplicable Start Date*: 2009-04-08
    Sponsor Name:University Hospital
    Full Title: Are cranberry capsules useful in preventing urinary tract infection in hip fracture patients with urinary tract catheter
    Medical condition: Urinary tract infections in patients with hip fractures.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10046571 Urinary tract infection LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-002321-10 Sponsor Protocol Number: PR11/2022 Start Date*: 2023-01-16
    Sponsor Name:Hospital Universitari d'Igualada
    Full Title: Effectiveness and safety of topical sevoflurane for the treatment of painful skin ulcers; randomized, double-blind, placebo-controlled clinical trial
    Medical condition: Cutaneous complex ulcers (grade II, III and IV) which are painful and require hospital care
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10065043 CMV mucocutaneous ulcer LLT
    21.0 100000004858 10045334 Ulcer skin LLT
    20.0 100000004858 10016980 Foot ulcer LLT
    20.0 100000004858 10077779 Pressure ulcer LLT
    21.0 100000004858 10077409 Ischemic skin ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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